Alcohol Consumption and Polymorphism of XRCC1 Gene: Two Serious Dangers for Males’ Fertility

Mirsane, Sayed Alireza; Oraei, Nasrin

doi:10.5812/numonthly.44424

Cited by 1 publication

(1 citation statement)

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“…Similarly, another study by Tsuchiya et al was excluded as it focused on investigating the association of XRCC1 gene polymorphisms with the susceptibility to testicular germ cell tumors, rather than male infertility [31]. Furthermore, another study by Mirsane et al was excluded as it investigated the relationship between XRCC1 polymorphism and alcohol consumption as a risk of male infertility [32]. Hence, a total of four case-control studies (1022 cases and 1004 controls), including the present study following a strict exclusion-inclusion criterion were included in the meta-analysis (Fig.…”

Section: Xrcc1: Rs25487 (A > G Pgln399arg)mentioning

confidence: 99%

SNPs in ERCC1, ERCC2, and XRCC1 genes of the DNA repair pathway and risk of male infertility in the Asian populations: association study, meta-analysis, and trial sequential analysis

Singh

Sudhakar

Neelabh

et al. 2018

J Assist Reprod Genet

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Purpose We investigated if substitutions in the ERCC1, ERCC2, and XRCC1 genes of the DNA repair pathway correlate with non-obstructive azoospermia and male infertility. Methods A total of 548 azoospermic infertile males and 410 fertile controls were genotyped for XRCC1 399A > G, 280G > A, and ERCC1 C > A 3′ UTR and 541 azoospermic infertile males and 416 fertile controls were genotyped for ERCC2 751A > C using iPLEX Gold Assay. Meta-analyses were performed on XRCC1 399A > G (1022 cases and 1004 controls), ERCC1 C > A 3′ UTR (879 cases and 1059 controls), and ERCC2 751A > C (914 cases and 850 controls) polymorphisms to quantitatively estimate the significance of the association between these polymorphisms and the risk of infertility. Results Statistically significant association between ERCC2 751A > C SNP and male infertility was found using the codominant model (p = 0.03). Results of meta-analysis suggested a lack of correlation with male infertility risk, which could be due to pooling of studies from different ethnic populations. Due to limited the number of studies, a stratified analysis for different ethnic groups could not be performed. Conclusion (s) In conclusion, AA genotype of 751A > C SNP in ERCC2 correlated with a higher risk of male infertility and may contribute to an increased risk of azoospermia and male infertility in Indian men.

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Section: Xrcc1: Rs25487 (A > G Pgln399arg)mentioning

confidence: 99%