Alcohol Consumption Can be a “Double-Edged Sword” for Chronic Kidney Disease Patients

Fan, Zhenliang; Yun, Jie; Yu, Shanshan; Yang, Qiaorui; Song, Limei

doi:10.12659/msm.916121

Cited by 29 publications

(26 citation statements)

References 121 publications

(210 reference statements)

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“…This study also found a significant correlation between alcohol consumption and CKD. Excessive alcohol consumption generally leads to liver damage but few studies have also found that ethanol can cause kidney damage 10 . Along with an unhealthy diet and lifestyle, heavy alcohol consumption can greatly contribute to CKD.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Chronic Kidney Disease Among Community Remote Areas in Sabah: Population-Based Study

Nizam

Noh²,

Shamsuddin³

2020

MHSJ

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In this population-based study, we determined the prevalence of chronic kidney disease of community in remote areas of Ranau, Sabah to have accurate information for health-care planning. It also investigated the association of risk factors with the prevalence of CKD. A sample of 270 individuals, compared to the study of the National Health and Morbidity Survey 2011, of the adult population (over 18 years old) undertaken in West Malaysia. We measured the estimated glomerular filtration rate (eGFR) using this CKD-EPI equation. The total prevalence of chronic kidney disease in this group was 53%. An estimated 3.3% had stage 1 chronic kidney disease (eGFR >90 ml/min per 1.73m2), 32.6% had stage 2 (eGFR 60–89 ml/min per 1.73m2), 4.1% had stage 3 (eGFR 30–59 ml/min per 1.73m2), 7% had stage 4 (eGFR 15–29 ml/min per 1.73m2), and 6% had stage 5 chronic kidney disease (eGFR <15 ml/min per 1.73m2). Only 4% of respondents with chronic kidney disease were aware of their diagnosis. The significant risk factors included family history of kidney disease, alcohol consumption, smoking status, hypertension, diabetes mellitus, and dyslipidemia. Thus, chronic kidney disease in East Malaysia is common and warrants early detection, and treatment to potentially improve outcomes can be implemented.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Chronic Kidney Disease Among Community Remote Areas in Sabah: Population-Based Study

Nizam

Noh²,

Shamsuddin³

2020

MHSJ

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“…Alcohol induces production of free radicals [36-40] and also decreases antioxidant capabilities of enzymes in the kidney [41-43]. In a recent comprehensive review on clinical studies looking at links between CKD and alcohol consumption, Fan et al (2019) concluded that light-to moderate drinking may not have adverse effects on patients with CKD [44]. While the DSM-5 definition of AUD does not quantify alcohol consumption [45], NIAAA defines moderate drinking as “up to 1 drink per day for women and up to 2 drinks per day for men” whereas “binge drinking and heavy alcohol use can increase an individual’s risk of alcohol use disorder” [46].…”

Section: Discussionmentioning

confidence: 99%

Mortality, disease progression, and disease burden of acute kidney injury in alcohol use disorder subpopulation

Green‐Saxena

Maharjan

et al. 2020

Preprint

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Objective: The objective of this study is to quantify the relationship between acute kidney injury (AKI) and alcohol use disorder (AUD), in terms of disease burden, mortality burden and disease progression. Methods: We used the University of California, San Francisco Medical Center in San Francisco, CA (UCSF) and Medical Information Mart for Intensive Care (MIMIC-III) databases to quantify AKI disease and mortality burden as well as AKI disease progression in the AUD and non-AUD subpopulations. We used the MIMIC-III dataset to compare two different methods of encoding AKI: ICD-9 codes, and the 2012 Kidney Disease: Improving Global Outcomes scheme (KDIGO). In addition to the AUD subpopulation (defined by AUD-related ICD-9 codes), we also present analysis for the hepatorenal syndrome (HRS) and alcohol-related cirrhosis subpopulations identified via ICD-9 coding. Results: In both the ICD-9 and KDIGO encodings of AKI, the AUD subpopulation had a higher prevalence of AKI (ICD-9: 48.59% vs. 29.99% AKI in the non-AUD subpopulations; KDIGO: 39.84% vs. 27.99%) in the MIMIC-III dataset. In the UCSF dataset, the AUD subpopulation also had a higher prevalence of AKI than the non-AUD subpopulation (ICD-9: 48.60% vs. 8.45%). The mortality rate of the subpopulation with both AKI and an AUD-related condition (AUD, HRS, or alcohol-related cirrhosis) was consistently higher than that of the subpopulation with only AKI in both datasets after adjusting for disease severity using two methods of severity estimation in the MIMIC-III dataset. Disease progression rates were similar for AUD and non-AUD subpopulations. Conclusions: Our work using the UCSF multi-ward academic hospital data and the MIMIC-III ICU dataset shows that the AUD patient subpopulation had a higher number of AKI patients than the non-AUD subpopulation, and that patients with both AKI and either AUD, HRS, or alcohol-related cirrhosis were shown to have higher rates of mortality than the non-AUD subpopulation with AKI. Trial Registration: Not applicable.

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“…Alcohol is highly caloric and excessive alcohol consumption can precipitate obesity and lead to obesity-related complications, including hypertension. Although the evidence of direct nephrotoxicity is lacking, many mechanisms of kidney injury associated with alcohol consumption have been proposed, including oxidative stress and renal disease caused by other systemic conditions [20].…”

Section: Secondary Hypertensionmentioning

confidence: 99%

Hypertension and Alcohol: A Mechanistic Approach

Okojie

Javed

Chiwome

et al. 2020

Cureus

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Hypertension is a global public health challenge and a major cause of morbidity and mortality. Alcohol is one of the most frequently abused substances around the world. The financial implications of treating hypertension are also significant. Developing successful strategies to prevent hypertension may be as important, if not more important, than managing the disease once it arises. In this review we assess the relationship between alcohol use and hypertension development. We have searched the available literature using the PubMed database and identified studies that discussed the relationship between alcohol use and either primary or any of the common causes of secondary hypertension. We found that heavy alcohol use was almost invariably associated with increased risk of developing primary hypertension, regardless of the age or gender of the participants. The relationship between low or moderate alcohol use and hypertension is less clear and some evidence even points towards possible protective effects. The pathophysiology behind the association is incompletely understood and a number of mechanisms have been proposed. Heavy alcohol use also increases the risk of insulin resistance and obstructive sleep apnea, known causes of secondary hypertension. It has also been linked to a state of hypercortisolism, sometimes called pseudo-Cushing state. Moderate alcohol consumption may be protective against diabetes and hyperthyroidism associated with Graves' disease. Overall, public health efforts should address the issue of heavy alcohol use. There does not appear to be enough evidence to recommend abstinence to those consuming low amounts of alcohol with the aim of protecting against hypertension. We believe that the current understanding of the issue is insufficient and that more both basic science and clinical research needs to be done.

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Alcohol Consumption Can be a “Double-Edged Sword” for Chronic Kidney Disease Patients

Cited by 29 publications

References 121 publications

Prevalence of Chronic Kidney Disease Among Community Remote Areas in Sabah: Population-Based Study

Prevalence of Chronic Kidney Disease Among Community Remote Areas in Sabah: Population-Based Study

Mortality, disease progression, and disease burden of acute kidney injury in alcohol use disorder subpopulation

Hypertension and Alcohol: A Mechanistic Approach

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