Alcohol consumption, cigarette smoking, and endometrial cancer risk: results from the Netherlands Cohort Study

Loerbroks, Adrian; Schouten, Leo J.; Goldbohm, R. Alexandra; Brandt, Piet A. van den

doi:10.1007/s10552-007-0127-x

Cited by 34 publications

(43 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study, smoking women had a decreased risk of endometrial cancer, which is in agreement with other prospective cohort studies (Terry et al, 2002;Viswanathan et al, 2005;Al-Zoughool et al, 2007;Loerbroks et al, 2007).…”

Section: Discussionsupporting

confidence: 93%

A population-based cohort study on sun habits and endometrial cancer

et al. 2009

View full text Add to dashboard Cite

BACKGROUND: No large cohort study has examined the risk of endometrial cancer in relation to sun exposure. METHODS: A population-based cohort study of 29 508 women who answered a questionnaire in 1990 -92, of whom 24 098 responded to a follow-up enquiry in 2000 -02. They were followed for an average of 15.5 years. RESULTS: Among the 17 822 postmenopausal women included, 166 cases of endometrial cancer were diagnosed. We used a multivariate Cox regression analysis adjusting for age and other selected demographic variables to determine the risk of endometrial cancer. Women using sun beds 43 times per year reduced their hazard risk (HR) by 40% (0.6, 95% confidence interval (CI) 0.4 -0.9) or by 50% when adjusting for body mass index or physical activity (HR 0.5, 95% CI 0.3 -0.9), and those women who were sunbathing during summer reduced their risk by 20% (HR 0.8 95% CI 0.5 -1.5) compared with women who did not expose themselves to the sun or to artificial sun (i.e., sun beds). CONCLUSION: Exposure to artificial sun by the use of sun beds 43 times per year was associated with a 40% reduction in the risk of endometrial cancer, probably by improving the vitamin D levels during winter.

show abstract

Section: Discussionsupporting

confidence: 93%

A population-based cohort study on sun habits and endometrial cancer

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Alcohol consumption has been investigated in several epidemiologic studies, most showing no association (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18), some showing positive associations (19)(20)(21)(22), and some negative associations (23,24). Given the inconclusive results, we sought to address prospectively whether alcohol consumption is associated with risk of endometrial cancer.…”

Section: Introductionmentioning

confidence: 99%

Long-term Alcohol Consumption and Risk of Endometrial Cancer Incidence: A Prospective Cohort Study

Friberg¹,

Wolk²

2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Alcohol consumption has been hypothesized to increase the risk of endometrial cancer. We used data from the prospective population-based Swedish Mammography Cohort including 61,226 women to examine the association between alcohol and endometrial cancer incidence. Alcohol consumption was assessed with validated food frequency questionnaires at baseline 1987 to 1990 and at follow-up in 1997. During a mean follow-up of 17.6 years, 687 endometrial cancer cases were identified in the Swedish cancer registries. We found no association between alcohol consumption and endometrial cancer risk after adjustment for age, body mass index, and smoking. The multivariable rate ratios (95% confidence intervals) for the three upper categories of long-term alcohol consumption as compared with no consumption were 1.01 (0.84-1.22) for <3.4 g/d, 1.01 (0.80-1.27) for 3.4 to 9.9 g/d, and 1.09 (0.71-1.67) for z10 g/d, respectively. The association did not differ by age, body mass index, folic acid intake, or postmenopausal hormone use in stratified analysis. In conclusion, our results suggest that low alcohol consumption (up to one drink per day) is unlikely to substantially influence risk of endometrial cancer.

show abstract

“…The corresponding pooled ORs for heavy drinkers were 0.84 (95% CI 0.37-1.90) from two cohort and 1.19 (95% CI 0.78-1.82) from four case-control studies, including the present one [7,8,47], in the absence of heterogeneity between strata (p = 0.458). [9,10,13,16], and 0.95 overall. The risk estimates slightly increased when considering the comparison between heavy drinkers and non/low drinkers (OR = 1.02 from five case-control [5,7,8,48], RR = 1.45 from three cohort studies [9,13,16], and RR = 1.18 overall).…”

Section: Meta-analysismentioning

confidence: 99%

“…Besides the present one, we identified 19 case-control [5-8, 28-40, 47, 48] and seven cohort studies [9,10,[12][13][14][15][16] considering the association between alcohol consumption and endometrial cancer risk. The main characteristics of the studies are described in Table 4.…”

Section: Meta-analysismentioning

confidence: 99%

“…Among seven prospective studies, five found no significant association between alcohol drinking and endometrial cancer risk [4,6,[9][10][11][12][13][14]. In particular, The Million Women Study, conducted in the United Kingdom on a cohort of about 954,000 non-hysterectomized women and including 4,118 endometrial cancer cases, found no relation for drinkers of C15 drinks/week when compared to moderate drinkers [9].…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Alcohol and endometrial cancer risk: a case–control study and a meta-analysis

Turati

Gallus

Tavani

et al. 2010

Cancer Causes Control

View full text Add to dashboard Cite

To evaluate the association between alcohol consumption and endometrial cancer risk, we analyzed data from a hospital-based case-control study, conducted in Italy between 1992 and 2006, on 454 endometrial cancer cases and 908 controls, and performed a meta-analysis updated to October 2009. Compared to never alcohol drinkers, the odds ratio was 1.03 (95% confidence interval, CI, 0.76-1.41) for < or = 7, 1.27 (95% CI 0.86-1.87) for 8-14, and 1.19 (95% CI 0.80-1.77) for > or = 15 drinks/week, with no trend in risk. No association emerged for wine, beer, and spirit consumption analyzed separately. The meta-analysis included 20 case-control and seven cohort studies, for a total of 13,120 cases. Compared to non/low drinkers, the pooled relative risks for drinkers were 0.90 (95% CI 0.80-1.01) for case-control studies, 1.01 (95% CI 0.90-1.14) for cohort studies, and 0.95 (95% CI 0.88-1.03) overall, with no heterogeneity between study design (p = 0.156). The overall estimate for heavy versus non/low drinkers was 1.12 (95% CI 0.87-1.45). The results were consistent according to selected study characteristics, including geographic area, definition of alcohol drinkers, and type of controls in case-control studies. Our findings provide evidence that alcohol drinking is not associated with endometrial cancer risk, although a weak positive association for very high drinkers cannot be excluded.

show abstract

Alcohol consumption, cigarette smoking, and endometrial cancer risk: results from the Netherlands Cohort Study

Cited by 34 publications

References 40 publications

A population-based cohort study on sun habits and endometrial cancer

A population-based cohort study on sun habits and endometrial cancer

Long-term Alcohol Consumption and Risk of Endometrial Cancer Incidence: A Prospective Cohort Study

Alcohol and endometrial cancer risk: a case–control study and a meta-analysis

Contact Info

Product

Resources

About