Alcohol Craving as a Predictor of Relapse

Schneekloth, Terry D.; Biernacka, Joanna M.; Hall‐Flavin, Daniel K.; Karpyak, Victor M.; Frye, Mark A.; Loukianova, Larissa L.; Stevens, Susanna R.; Drews, Maureen S.; Geske, Jennifer R.; Mrazek, David A.

doi:10.1111/j.1521-0391.2012.00297.x

Cited by 86 publications

(64 citation statements)

References 22 publications

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“…8 While this study included patients with co-morbid drug dependence, we excluded patients with any drug use in the 6 months preceding their admission to the IAP. There was no association between PACS scores and relapse in our current cohort which was also smaller and had a shorter duration of follow up compared to the previous study.…”

Section: Discussionmentioning

confidence: 99%

“…Also, few studies accounted for the use of hypnotic medications, use of alcohol to fall asleep, and the intensity of craving, all of which could influence relapse risk. 7,8 Thus, the relationship between subjective sleep disturbances, which are common following alcohol treatment, and relapse is unclear, with studies reporting divergent findings. While the earlier two studies explicitly examining the relationship between subjective sleep disturbances and relapse reported an association, other more recent studies did not find such an association.…”

Section: Introductionmentioning

confidence: 99%

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The association between sleep disturbances and alcohol relapse: A 12-month observational cohort study

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The association between sleep disturbances and alcohol relapse: A 12-month observational cohort study

et al. 2015

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“…Alcohol-related cues, including the sight and smell of alcohol drinks, acquire conditioned incentive properties (Barker and Taylor, 2014;Field and Duka, 2002), can provoke intense craving in individuals that abuse or have lost control over alcohol (Ludwig, 1986;De Bruijn et al, 2004), and may be a predictor of relapse after abstinence (Schneekloth et al, 2012).…”

Section: Cue-controlled Alcohol-seeking Behavioral Proceduresmentioning

confidence: 99%

The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking

Giuliano

Goodlett

Economidou

et al. 2015

Neuropsychopharmacol

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Distinct environmental and conditioned stimuli influencing ethanol-associated appetitive and consummatory behaviors may jointly contribute to alcohol addiction. To develop an effective translational animal model that illuminates this interaction, daily seeking responses, maintained by alcohol-associated conditioned stimuli (CSs), need to be dissociated from alcohol drinking behavior. For this, we established a procedure whereby alcohol seeking maintained by alcohol-associated CSs is followed by a period during which rats have the opportunity to drink alcohol. This cue-controlled alcohol-seeking procedure was used to compare the effects of naltrexone and GSK1521498, a novel selective μ-opioid receptor antagonist, on both voluntary alcohol-intake and alcohol-seeking behaviors. Rederived alcohol-preferring, alcohol-nonpreferring, and high-alcohol-drinking replicate 1 line of rats (Indiana University) first received 18 sessions of 24 h home cage access to 10% alcohol and water under a 2-bottle choice procedure. They were trained subsequently to respond instrumentally for access to 15% alcohol under a second-order schedule of reinforcement, in which a prolonged period of alcohol-seeking behavior was maintained by contingent presentations of an alcohol-associated CS acting as a conditioned reinforcer. This seeking period was terminated by 20 min of free alcohol drinking access that achieved significant blood alcohol concentrations. The influence of pretreatment with either naltrexone (0.1 − 1 − 3 mg/kg) or GSK1521498 (0.1-1-3 mg/kg) before instrumental sessions was measured on both seeking and drinking behaviors, as well as on drinking in the 2-bottle choice procedure. Naltrexone and GSK1521498 dose-dependently reduced both cue-controlled alcohol seeking and alcohol intake in the instrumental context as well as alcohol intake in the choice procedure. However, GSK1521498 showed significantly greater effectiveness than naltrexone, supporting its potential use for promoting abstinence and preventing relapse in alcohol addiction.

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“…Alcohol craving, the urge to drink, is associated with an increased risk of relapse among people with AUD [11][12][20][21]. More severe [13] and more frequent [14] alcohol craving is reported by people with PTSD and cooccurring AUD relative to people with AUD alone.…”

Section: Relationship Between Alcohol Use Disorder And Alcohol Cravingmentioning

confidence: 99%

Alcohol use and craving among Veterans with mental health disorders and mild traumatic brain injury

et al. 2014

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Alcohol Craving as a Predictor of Relapse

Cited by 86 publications

References 22 publications

The association between sleep disturbances and alcohol relapse: A 12-month observational cohort study

The association between sleep disturbances and alcohol relapse: A 12-month observational cohort study

The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking

Alcohol use and craving among Veterans with mental health disorders and mild traumatic brain injury

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