Alcohol-Induced Endothelial Changes Are Associated With Oxidative Stress and Are Rapidly Reversed After Withdrawal

Soardo, Giorgio; Donnini, Debora; Varutti, Rosanna; Moretti, Massimo; Milocco, C.; Basan, Lorenza; Esposito, W.; Casaccio, Daniele; Stel, Giuliana; Catena, Cristiana; Curcio, Francesco; Sechi, Leonardo Antonio

doi:10.1097/01.alc.0000183004.28587.23

Cited by 42 publications

(43 citation statements)

References 46 publications

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“…Also, for MDA, the main marker of the lipid peroxidation processes, while several studies have found elevated levels in the serum of patients undergoing alcohol withdrawal (20,22,29), there are also reports describing clear reductions in the various markers lipid peroxidation following alcohol withdrawal (12,30).…”

Section: Discussionmentioning

confidence: 99%

The Relevance of Oxidative Stress Status in One Week and One Month Alcohol Abstinent Patients

Alexinschi¹,

Chiriță²,

Ciobîcă³

et al. 2014

Journal of Medical Biochemistry

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SummaryBackground: Although it is generally accepted that there is an increased oxidative stress status in alcoholics, the separate relevance of oxidative stress following alcohol withdrawal is still not understood to this date. There are reports stating that the increased oxidative stress status in alcoholics may persist independently of the constant presence of alcohol intake, while on the other side, it was demonstrated that the antioxidant defense mechanism could significantly increase after alcohol withdrawal. Methods: In the present work, we were interested in studying the relevance of oxidative stress status in the alcohol withdrawal processes, by determining some oxidative stress markers (two antioxidant enzymes: superoxide dismutase -SOD and glutathione peroxidase -GPX and a lipid peroxidation maker -MDA) after one week and one month of abstinence, as compared to the baseline and a control group of subjects. Results: Our data confirmed the increased oxidative stress status in alcoholic patients and, more importantly, we de monstrated here a significant decrease of the oxidative stress status one week and one month following the withdrawal, as showed by a significant increase in the specific activity of

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Section: Discussionmentioning

confidence: 99%

The Relevance of Oxidative Stress Status in One Week and One Month Alcohol Abstinent Patients

Alexinschi¹,

Chiriță²,

Ciobîcă³

et al. 2014

Journal of Medical Biochemistry

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“…As the scavengers of oxidants prevented those changes, oxidative stress may have a role in the alcohol-induced endothelial dysfunction. 30 It was, however, reported that the flowmediated dilation of the brachial artery and blood markers of endothelial function were similar between the usual drinking period and the alcohol restriction period in healthy men. 31 On the other hand, low concentrations of alcohol usually dilate blood vessels.…”

Section: Cardiovascular Actions Of Alcoholmentioning

confidence: 93%

“…27,28 It has been suggested that endothelin and nitric oxide are involved in alcohol-induced vasoconstriction. 29 Soardo et al 30 observed that alcohol increased the levels of endothelin-1, nitric oxide, plasminogen activator inhibitor-1 and oxidative stress both in vivo and in vitro. As the scavengers of oxidants prevented those changes, oxidative stress may have a role in the alcohol-induced endothelial dysfunction.…”

Section: Cardiovascular Actions Of Alcoholmentioning

confidence: 99%

Physio-pathological effects of alcohol on the cardiovascular system: its role in hypertension and cardiovascular disease

Kawano

2010

Hypertens Res

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Alcohol has complex effects on the cardiovascular system. The purpose of this article is to review physio-pathological effects of alcohol on cardiovascular and related systems and to describe its role in hypertension and cardiovascular disease. The relationship between alcohol and hypertension is well known, and a reduction in the alcohol intake is widely recommended in the management of hypertension. Moreover, alcohol has both pressor and depressor actions. The latter actions are clear in Oriental subjects, especially in those who show alcohol flush because of the genetic variation in aldehyde dehydrogenase activity. Repeated alcohol intake in the evening causes an elevation in daytime and a reduction in nighttime blood pressure (BP), with little change in the average 24-h BP in Japanese men. Thus, the hypertensive effect of alcohol seems to be overestimated by the measurement of casual BP during the day. Heavy alcohol intake seems to increase the risk of several cardiovascular diseases, such as hemorrhagic stroke, arrhythmia and heart failure. On the other hand, alcohol may act to prevent atherosclerosis and to decrease the risk of ischemic heart disease, mainly by increasing HDL cholesterol and inhibiting thrombus formation. A J-or U-shaped relationship has been observed between the level of alcohol intake and risk of cardiovascular mortality and total mortality. It is reasonable to reduce the alcohol intake to less than 30 ml per day for men and 15 ml per day for women in the management of hypertension. As a small amount of alcohol seems to be beneficial, abstinence from alcohol is not recommended to prevent cardiovascular disease. INTRODUCTIONAlcohol has complex effects on the cardiovascular system. The relationship between alcohol and hypertension is well known, and a restriction of alcohol intake is widely recommended as a part of lifestyle modifications in the management of hypertension. 1-6 Alcohol has both pressor and depressor actions, however, and the genetic susceptibility regarding alcohol metabolism influences the cardiovascular effect of alcohol. 3,7 The effect of alcohol on blood pressure (BP) is also modified by several factors, such as the level of consumption, time period after the last drink and overall drinking behavior.Alcohol consumption is associated with several cardiovascular diseases, such as brain hemorrhage, heart failure and arrhythmia, as well as with other disorders. 3,[8][9][10][11] Heavy drinking and alcoholism not only lead to medical problems but are also serious social concerns. However, alcohol also seems to have beneficial effects, including the prevention of ischemic heart disease. It has been shown that cardiovascular and all-cause mortality is lower in light drinkers compared with nondrinkers. 3,[8][9][10][11][12] The purpose of this article is to review physio-pathological effects of alcohol on cardiovascular and related systems and to describe its role

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“…Many studies have confirmed that chronic alcohol abuse is associated with important impairments in endothelial function (Di Gennaro et al, 2007;Maiorano et al, 1999;Zilkens et al, 2003). This effect is thought to be due to the increased oxidative stress produced by excessive amounts of alcohol, causing endothelial cell apoptosis (Croft et al, 1996;Soardo et al, 2005;Spyridopoulos et al, 2001;Sun & Mayhan, 2001). Large quantities of alcohol may also impair the production of nitric oxide (Persson & Gustafsson, 1992).…”

Section: Alcohol Consumption and Cvdmentioning

confidence: 98%

Mood Disorders and Cardiovascular Disease

Gordon¹,

Lavoie²,

Arsenault³

et al. 2012

Clinical, Research and Treatment Approaches to Affective Disorders

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Alcohol-Induced Endothelial Changes Are Associated With Oxidative Stress and Are Rapidly Reversed After Withdrawal

Abstract: Alcohol affects endothelial function with an effect that is mediated by an activated oxidative stress and is rapidly reversed after withdrawal. Dose-related endothelial responses to different alcohol intakes might translate in either vascular protection or vascular damage.

Cited by 42 publications

References 46 publications

The Relevance of Oxidative Stress Status in One Week and One Month Alcohol Abstinent Patients

The Relevance of Oxidative Stress Status in One Week and One Month Alcohol Abstinent Patients

Physio-pathological effects of alcohol on the cardiovascular system: its role in hypertension and cardiovascular disease

Mood Disorders and Cardiovascular Disease

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