Alcohol intake and cause-specific mortality: conventional and genetic evidence in a prospective cohort study of 512 000 adults in China

Millwood, Iona Y; Im, Pek Kei; Bennett, Derrick; Hariri, Parisa; Yang, Ling; Du, Huaidong; Kartsonaki, Christiana; Lin, Kuang; Yu, Canqing; Chen, Yiping; Sun, Dianjianyi; Zhang, Ningmei; Avery, Daniel; Schmidt, Dan; Pei, Pei; Chen, Junshi; Clarke, Robert; Lv, Jun; Peto, Richard; Walters, Robin G; Li, Liming; Chen, Zhengming

doi:10.1016/s2468-2667(23)00217-7

Cited by 29 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…So, when considering the mental health hazards of drinking, we should pay attention to cultural customs, social beliefs, and other factors related to psychological health. Moreover, a previous study clarified the causal effects of alcohol intake on the increased risk of death (Millwood, et al, 2023), and there was no evidence of protection from moderate drinking. Accordingly, intervention strategies aimed at curbing alcohol intake should fully consider the social and cultural environment and seek to influence attitudes and beliefs about alcohol from a conceptual level, respecting the cultural context of drinking while simultaneously imparting an awareness of the potential harms.…”

Section: Discussionmentioning

confidence: 92%

Alcohol Drinking and Psychological Health Outcome

Wu,

Liu,

et al. 2024

European Journal of Psychology Open

View full text Add to dashboard Cite

Objective: This paper explores the relationship between alcohol consumption and psychological health outcome in an economically underdeveloped area of China. Methods: We conducted convenience sampling and recruited 439 participants at alcohol-related risk as identified by Alcohol Use Disorder Identification Test. Well-being and mental health were the primary outcomes. We employed multiple regression analysis to determine the correlation between alcohol consumption and health outcome. Results: Participants with higher scores for alcohol dependence were more likely to obtain higher scores for stress (0.11 [95% CI: 0.03, 0.19]), anxiety (0.15 [95% CI: 0.07, 0.23]) and depression (0.11 [95% CI: 0.03, 0.19]). Similarly, increasing scores for harmful alcohol use items were associated with higher scores for anxiety (0.08 [95% CI: 0.01,0.16]) and stress (0.08 [95% CI: 0.01,0.15]) and lower scores for positiveness (0.07 [95% CI: –0.14, –0.01]). Participants with stable incomes and the ethnic minority reported more favorable psychological outcomes or fewer negative emotions. Conversely, individuals who drank passively were more prone to experiencing lower positive and higher negative psychological effects. Conclusions: Higher scores on measures of alcohol dependence and harmful alcohol use indicate elevated psychological risks. Socioeconomic status, ethnicity, and drinking motivations modified the associations.

show abstract

Section: Discussionmentioning

confidence: 92%

Alcohol Drinking and Psychological Health Outcome

Wu,

Liu,

et al. 2024

European Journal of Psychology Open

View full text Add to dashboard Cite

show abstract

“…That might be because of moderate alcohol consumption. Although, there was no confirmed evidence of protection from moderate drinking for all-cause and cause-specific mortality ( 26 , 27 ).…”

Section: Discussionmentioning

confidence: 92%

Remnant cholesterol and all-cause mortality risk: findings from the National Health and Nutrition Examination Survey, 2003-2015

Bai,

Liao,

Wang

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

AimsCholesterol carried in triglyceride-rich lipoproteins, also called remnant cholesterol, is increasingly acknowledged as an important causal risk factor for atherosclerosis. Elevated remnant cholesterol, marked by elevated plasma triglycerides, is associated causally with an increased risk of atherosclerotic cardiovascular disease. However, the association with all-cause mortality and cause-specific mortality is inconclusive. This study aimed to test the hypothesis that remnant cholesterol levels and plasma triglycerides are associated with increased all-cause mortality and mortality from cardiovascular disease, cancer, and other causes.Methods and resultsUsing a contemporary population-based cohort, 7,962 individuals from the National Health and Nutrition Examination Survey (NHANES) aged over 40 years at baseline in 2003–2015 were included. During up to 109.2 (± 1.44) months of follow-up, 1,323 individuals died: 385 individuals died from cardiovascular disease, 290 from cancer, 80 from cerebrovascular disease, and 568 from other causes. Compared with the middle tertile remnant cholesterol level, multivariable-adjusted mortality hazard ratios were 1.20 (95% confidence interval 1.02–1.40) for all-cause mortality. For the highest tertile remnant cholesterol level, multivariable-adjusted mortality hazard ratios were 1.21 (95% confidence interval 1.05,1.40). Our conclusions remained stable in subgroup analyses. Exploratory analysis of the cause of death subcategories showed corresponding hazard ratios of 1.25 (1.13–1.38) for Non-cardiovascular and Non-cerebrovascular Death for lower remnant cholesterol individuals, 1.47 (1.01–2.15) for cancer death for lower remnant cholesterol (RC) individuals, and 1.80 (1.36–2.38) for cancer death for higher RC individuals.ConclusionRC levels were associated with U-shaped all-cause mortality. RC was associated with mortality from non-cardiovascular, non-cerebrovascular, and cancer, but not from cardiovascular causes. This novel finding should be confirmed in other cohorts.

show abstract

“…Another recent study looked at cause-specific and all-cause mortality using MR-this time in men only (Millwood et al, 2023). It found that-in contrast to observational analyses of the same large Chinese cohort-there was no causal evidence of protective effects of lowlevel drinking.…”

Section: Ausal Me Thods and The J -S Hape-what Doe S The E Viden Ce S...mentioning

confidence: 99%

Is low‐level alcohol consumption really health‐protective? A critical review of approaches to promote causal inference and recent applications

Visontay,

Mewton,

Sunderland

et al. 2024

Alcohol, Clinical and Experimental Research

View full text Add to dashboard Cite

Heavy and disordered alcohol consumption is a known risk factor for several health conditions and is associated with considerable disease burden. However, at low‐to‐moderate levels, evidence suggests that drinking is associated with reduced risk for certain health outcomes. Whether these findings represent genuine protective effects or mere methodological artifacts remains unclear, but has substantial consequences for policy and practice. This critical review introduces methodological advances capable of enhancing causal inference from observational research, focusing on the ‘G‐methods’ and Mendelian Randomization. We also present and evaluate recent research applying these methods and compare findings to the existing evidence base. Future directions are proposed for improving our causal understanding of the relationships between alcohol and long‐term health outcomes.

show abstract

Alcohol intake and cause-specific mortality: conventional and genetic evidence in a prospective cohort study of 512 000 adults in China

Cited by 29 publications

References 28 publications

Alcohol Drinking and Psychological Health Outcome

Alcohol Drinking and Psychological Health Outcome

Remnant cholesterol and all-cause mortality risk: findings from the National Health and Nutrition Examination Survey, 2003-2015

Is low‐level alcohol consumption really health‐protective? A critical review of approaches to promote causal inference and recent applications

Contact Info

Product

Resources

About