Alcohol use disorder‐associated structural and functional characteristics of the insula

Manuweera, Thushini; Kisner, Mallory A.; Almira, Erika; Momenan, Reza

doi:10.1002/jnr.25113

Cited by 7 publications

(11 citation statements)

References 85 publications

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“…37,50 While the current study offered no direct analysis of the relationships between craving and anatomical measures, putting altogether prior findings on insular interoceptive processing path with the hypothesized role of insula as the craving neural substrate 10,11,43 would imply that the patient groups show an atrophy of the insular part (subregion and laterality) responsible for the substance consumed embodiment effects. 20 When going further in such hypothesized implication, this could possibly mean that the postero-anterior gradient of atrophy could in fact also be interpreted in the framework of addiction models, which posit the insula as being involved in both bottom-up and top-down processes, 11,43,49 depending on the stage of substance use disorder development. 51 At the early stages, the urge for substance use follows a bottom-up process: craving emerges from environmental cues.…”

Section: Discussionmentioning

confidence: 99%

“…Future venues would therefore be to also investigate insular metabolic activity as well as functional and structural connectivity. 20 Moreover, it would also be of interest to compare GM insular volume in different substance use disorders.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, although providing insula GM volume evidence in both KS and sAUD patients, this study was limited to solely one imaging modality. Future venues would therefore be to also investigate insular metabolic activity as well as functional and structural connectivity 20 . Moreover, it would also be of interest to compare GM insular volume in different substance use disorders.…”

Section: Discussionmentioning

confidence: 99%

“…A concrete illustration of insular heterogenous parcellation deleterious consequences is the current state of findings in the AUD field. Although AUD investigation is scarce, the few results show major heterogeneity because findings do not concur, neither on lateralization (in right 16 or left 17 versus bilateral 18 insula) nor regions (in whole right 16 versus bilateral anterior 19 insula or aggravated in bilateral anterior and left posterior insula 20 ) atrophy in patients presenting sAUD. Moreover, all previous studies (with the exception of a previous study, 17 which was not specifically exploring the insula) focused solely on sAUD, without exploring insular alterations following alcohol‐related neurological complications such as Korsakoff's syndrome (KS).…”

Section: Introductionmentioning

confidence: 97%

“…21 Given prior evidence for a graduation of atrophy between HC, sAUD and KS, 17 we hypothesized that both patients with KS and sAUD would show insular grey matter atrophy compared to HC, but that this atrophy would be more severe in the KS group. Based on the previous reports that insular atrophy might vary with lateralization 16,17 and subregions, 20 we explored the role of such variables in the patterns of grey matter atrophy observed in each clinical group.…”

Section: Introductionmentioning

confidence: 99%

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Insular volumetry in severe alcohol use disorder and Korsakoff's syndrome through an anatomical parcellation: Let us go back to basics

Billaux,

Maurage,

Cabé

et al. 2023

Addiction Biology

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Functional neuroimaging has demonstrated the key role played by the insula in severe alcohol use disorder (sAUD), notably through its involvement in craving and body signals processing. However, the anatomical counterpart of these functional modifications in sAUD patients with and without neurological complications remains largely unexplored, especially using state‐of‐the‐art parcellation tools. We thus compared the grey matter volume of insular subregions (form anterior to posterior: anterior inferior cortex, anterior short gyrus, middle short gyrus, posterior short gyrus, anterior long gyrus, posterior long gyrus) in 50 recently detoxified patients with sAUD, 19 patients with Korsakoff's syndrome (KS) and 36 healthy controls (HC). We used a mixed linear model analysis to explore group differences in the six subregions grey matter volume and lateralization differences. Insular macrostructure was globally affected to the same extent in sAUD with and without KS, indicating that these brain abnormalities may be related to alcohol consumption per se, rather than to the presence of alcohol‐related neurological complications. Insular atrophy showed a right‐sided lateralization effect and was especially marked in the posterior insula, a region associated with visceral information processing and the embodiment effect of a substance, from which craving arises. Anatomical damages might thus underlie the previously reported altered insular activations and their behavioural counterparts.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Insular volumetry in severe alcohol use disorder and Korsakoff's syndrome through an anatomical parcellation: Let us go back to basics

Billaux,

Maurage,

Cabé

et al. 2023

Addiction Biology

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Brain Networks and Adolescent Alcohol Use

Yip,

Lichenstein,

Liang

et al. 2023

JAMA Psychiatry

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ImportanceAlcohol misuse in adolescence is a leading cause of disability and mortality in youth and is associated with higher risk for alcohol use disorder. Brain mechanisms underlying risk of alcohol misuse may inform prevention and intervention efforts.ObjectiveTo identify neuromarkers of alcohol misuse using a data-driven approach, with specific consideration of neurodevelopmental sex differences.Design, Setting, and ParticipantsLongitudinal multisite functional magnetic resonance imaging (fMRI) data collected at ages 14 and 19 years were used to assess whole-brain patterns of functional organization associated with current and future alcohol use risk as measured by the Alcohol Use Disorder Identification Test (AUDIT). Primary data were collected by the IMAGEN consortium, a European multisite study of adolescent neurodevelopment. Model generalizability was further tested using data acquired in a single-site study of college alcohol consumption conducted in the US. The primary sample was a developmental cohort of 1359 adolescents with neuroimaging, phenotyping, and alcohol use data. Model generalizability was further assessed in a separate cohort of 114 individuals.Main Outcomes and MeasuresBrain-behavior model accuracy, as defined by the correspondence between model-predicted and actual AUDIT scores in held-out testing data, Bonferroni corrected across the number of models run at each time point, 2-tailed α &lt; .008, as determined via permutation testing.ResultsAmong 1359 individuals in the study, the mean (SD) age was 14.42 (0.40) years, and 729 individuals (54%) were female. The data-driven, whole-brain connectivity approach identified networks associated with vulnerability for future and current AUDIT-defined alcohol use risk (primary outcome, as specified above, future: ρ, 0.22; P &lt; .001 and present: ρ, 0.27; P &lt; .001). Results further indicated sex divergence in the accuracies of brain-behavior models, such that female-only models consistently outperformed male-only models. Specifically, female-only models identified networks conferring vulnerability for future and current severity using data acquired during both reward and inhibitory fMRI tasks. In contrast, male-only models were successful in accurately identifying networks using data acquired during the inhibitory control—but not reward—task, indicating domain specificity of alcohol use risk networks in male adolescents only.Conclusions and RelevanceThese data suggest that interventions focusing on inhibitory control processes may be effective in combating alcohol use risk in male adolescents but that both inhibitory and reward-related processes are likely of relevance to alcohol use behaviors in female adolescents. They further identify novel networks of alcohol use risk in youth, which may be used to identify adolescents who are at risk and inform intervention efforts.

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Altered Physiological, Affective, and Functional Connectivity Responses to Acute Stress in Patients With Alcohol Use Disorder

Schwarze,

Voges,

Schröder

et al. 2024

Biological Psychiatry Global Open Science

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Alcohol use disorder‐associated structural and functional characteristics of the insula

Cited by 7 publications

References 85 publications

Insular volumetry in severe alcohol use disorder and Korsakoff's syndrome through an anatomical parcellation: Let us go back to basics

Insular volumetry in severe alcohol use disorder and Korsakoff's syndrome through an anatomical parcellation: Let us go back to basics

Brain Networks and Adolescent Alcohol Use

Altered Physiological, Affective, and Functional Connectivity Responses to Acute Stress in Patients With Alcohol Use Disorder

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