Aldosterone biosynthesis in the human adrenal cortex and associated disorders

Nakamura, Yasuhiro; Yamazaki, Yuto; Konosu-Fukaya, Sachiko; Ise, Kazue; Satoh, Fumitoshi; Sasano, Hironobu

doi:10.1016/j.jsbmb.2015.05.008

Cited by 14 publications

(15 citation statements)

References 58 publications

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“…The mature adrenal cortex is divided in three distinct zones that produce a complex array of adrenocortical steroid hormones: mineralocorticoids in the zona glomerulosa (ZG), glucocorticoids in the zona fasciculata (ZF) and adrenal androgens in the zona reticularis (ZR) 3. Recently, Gomez-Sanchez et al demonstrated a zone-specific location of the steroidogenic enzymes CYP11B1 in ZF and CYP11B2 in ZG, involved in the final steps of biosynthesis of cortisol and aldosterone, respectively, while CYP11A, HSD3β and CYP21A2 are all expressed in both zonae 4.…”

Section: Introductionmentioning

confidence: 99%

Alterations of adrenal steroidomic profiles in preterm infants at birth

Travers

Boileau

Lombès

et al. 2017

Arch Dis Child Fetal Neonatal Ed

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Section: Introductionmentioning

confidence: 99%

Alterations of adrenal steroidomic profiles in preterm infants at birth

Travers

Boileau

Lombès

et al. 2017

Arch Dis Child Fetal Neonatal Ed

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“…In the analysis of pathways, we found that aldosterone synthesis and secretion, Rap1 signaling pathway, and arrhythmogenic right ventricular cardiomyopathy have a statistical relation. Regarding the aldosterone synthesis and secretion pathway, it has been reported that aldosterone synthesis is stimulated by increased levels of adrenocorticotropic hormone like cortisol (Nakamura et al, ). This enzyme is presented in the brain in negligible concentrations, and its role has been related with stress, fear, anxiety, and other psychiatric disorders (Borraz‐Leon, Cerda‐Molina, & Mayagoitia‐Novales, ).…”

Section: Discussionmentioning

confidence: 99%

Identification of gene ontology and pathways implicated in suicide behavior: Systematic review and enrichment analysis of GWAS studies

González‐Castro

Tovilla‐Zárate

Genis‐Mendoza

et al. 2019

American J of Med Genetics Pt B

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Multiple large-scale studies such as genome-wide association studies (GWAS) have been performed to identify genetic contributors to suicidal behaviors (SB). We aimed to summarize and analyze the information obtained in SB GWAS, to explore the biological process gene ontology (GO) of genes associated with SB from GWAS, and to determine the possible implications of the genes associated with SB in Kyoto encyclopedias of genes and genomes (KEGG) biological pathways. The articles included in the analysis were obtained from PubMed and Scopus databases. Enrichment analyses were performed in Enrichr to evaluate the KEGG pathways and GO of the genes associated with SB of GWAS. The findings of biological process GO analysis showed 924 GO involved in genes related with SB; of those, the regulation of glucose import in response to insulin stimulus, regulation of protein localization to plasma membrane, positive regulation of endopeptidase activity, heterotypic cell-cell adhesion, regulation of cardiac muscle cell contraction, positive regulation of protein localization to plasma membrane, and positive regulation of protein localization to cell periphery biological process GO showed significant statistical association. Furthermore, we obtained 130 KEGG pathways involved in genes related with SB, which Aldosterone synthesis and secretion, Rap1 signaling pathway and arrhythmogenic right ventricular cardiomyopathy pathways showed a significant statistical association. These findings give a better perspective of the biological participation of genes associated with SB, which will be important to perform adequate strategies to prevent and treat SB.

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“…The pathogenesis of AHT involves the renal, vascular, and endocrine systems ( 12 – 15 ), affecting mainly sodium-water reabsorption and arterial vasoconstriction. Pathological conditions, such as primary aldosteronism (PA), are responsible for up to 5–10% of patients diagnosed with AHT, and involve an increased production of aldosterone that leads to AHT, cardiovascular damage, heart diseases ( 16 – 18 ), and renal and immune alterations ( 19 – 23 ). Aldosterone is a mineralocorticoid hormone with non-genomic and genomic actions; the latter through the mineralocorticoid receptors (MR) can alter sodium transport in renal collecting ducts, increase water uptake, blood volume, and eventually raise blood pressure.…”

Section: Arterial Hypertension (Aht)mentioning

confidence: 99%

Urinary Exosomes and Their Cargo: Potential Biomarkers for Mineralocorticoid Arterial Hypertension?

Barros

Carvajal

2017

Front. Endocrinol.

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Arterial hypertension (AHT) currently affects approximately 40% of adults worldwide, and its pathological mechanisms are mainly related to renal, vascular, and endocrine systems. Steroid hormones as aldosterone and cortisol are highly relevant to human endocrine physiology, and also to endocrine hypertension. Pathophysiological conditions, such as primary aldosteronism, affect approximately 10% of patients diagnosed with AHT and are secondary to a high production of aldosterone, increasing the risk also for cardiovascular damage and heart diseases. Excess of aldosterone or cortisol increases the activity of the mineralocorticoid receptor (MR) in epithelial and non-epithelial cells. Current research in this field highlights the potential regulatory mechanisms of the MR pathway, including pre-receptor regulation of the MR (action of 11BHSD2), MR activating proteins, and the downstream genes/proteins sensitive to MR (e.g., epithelial sodium channel, NCC, NKCC2). Mineralocorticoid AHT is present in 15–20% of hypertensive subjects, but the mechanisms associated to this condition have been poorly described, due mainly to the absence of reliable biomarkers. In this way, steroids, peptides, and lately urinary exosomes are thought to be potential reporters of biological processes. This review highlight exosomes and their cargo as potential biomarkers of metabolic changes associated to mineralocorticoid AHT. Recent reports have shown the presence of RNA, microRNAs, and proteins in urinary exosomes, which could be used as biomarkers in physiological and pathophysiological conditions. However, more studies are needed in order to benefit from exosomes and the exosomal cargo as a diagnostic tool in mineralocorticoid AHT.

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Aldosterone biosynthesis in the human adrenal cortex and associated disorders

Cited by 14 publications

References 58 publications

Alterations of adrenal steroidomic profiles in preterm infants at birth

Alterations of adrenal steroidomic profiles in preterm infants at birth

Identification of gene ontology and pathways implicated in suicide behavior: Systematic review and enrichment analysis of GWAS studies

Urinary Exosomes and Their Cargo: Potential Biomarkers for Mineralocorticoid Arterial Hypertension?

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