Aldosterone regulates cellular turnover and mitogen‐activated protein kinase family expression in the neonatal rat kidney

Yim, Hyung Eun; Yoo, Kee Hwan; Bae, In Sun; Jang, Gi Young; Hong, Young Sook; Lee, Joo Won

doi:10.1002/jcp.21723

Cited by 17 publications

(12 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cell Apoptosis, Macrophage Infiltration, Glomerulosclerosis, and Tubulointerstitial Fibrosis To detect cellular changes, TUNEL staining was carried out as described previously (36,37). IHC was performed against the rat monocytespecific marker CD68 (ED1; 1: 100; Abdserotec, Kidlington, UK) to analyze monocyte/macrophage infiltrations.…”

Section: Biochemical Analysismentioning

confidence: 99%

Postnatal early overnutrition causes long-term renal decline in aging male rats

et al. 2013

Self Cite

View full text Add to dashboard Cite

Background:We evaluated the influence of postnatal early overnutrition on renal pathophysiological changes in aging rats. Methods: Three or 10 male pups per mother were assigned to either the small litter (SL) or normal litter (control) groups, respectively, during the first 21 d of life. The effects of early postnatal overnutrition were determined at 12 mo. results: SL rats weighed more than controls between 4 d and 6 mo of age (P < 0.05). However, between 6 and 12 mo, body weights in both groups were not different. In the SL group, at 12 mo, systolic blood pressure was higher and creatinine clearance was lower than the same in controls (P < 0.05). Numbers of CD68 (ED1)-positive macrophages and apoptotic cells in renal cortex were higher in SL rats (P < 0.05). Furthermore, index scores for glomerulosclerosis and tubulointerstitial fibrosis were higher in the SL group (P < 0.05). Significantly less glomeruli per section area were found in aging SL rats (P < 0.05). Immunoblotting and immunohistochemistry showed decreased intrarenal renin expression in SL rats (P < 0.05). conclusion: Early postnatal overnutrition can potentiate structural and functional abnormalities in the aging kidney and can lead to systolic hypertension with reduced intrarenal renin activity.

show abstract

Section: Biochemical Analysismentioning

confidence: 99%

Postnatal early overnutrition causes long-term renal decline in aging male rats

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

“…Placental size in rats and humans is positively correlated with plasma levels of aldosterone [16]. Thus, aldosterone may positively modulate placental growth, similar to its proliferative capabilities in organs such as the heart and the kidney [36,39].…”

Section: Mice (Unpublished Observations)mentioning

confidence: 99%

Aldosterone deficiency adversely affects pregnancy outcome in mice

Todkar

Chiara

Loffing‐Cueni

et al. 2012

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

Circulating aldosterone levels are increased in human pregnancy. Inadequately low aldosterone levels as present in preeclampsia, a life-threatening disease for both mother and child, are discussed to be involved in its pathogenesis or severity. Moreover, inactivating polymorphisms in the aldosterone synthase gene have been detected in preeclamptic women. Here, we used aldosterone synthase-deficient (AS(-/-)) mice to test whether the absence of aldosterone is sufficient to impair pregnancy or even to cause preeclampsia. AS(-/-) and AS(+/+) females were mated with AS(+/+) and AS(-/-) males, respectively, always generating AS(+/-) offspring. With maternal aldosterone deficiency in AS(-/-) mice, systolic blood pressure was low before and further reduced during pregnancy with no increase in proteinuria. Yet, AS(-/-) had smaller litters due to loss of fetuses as indicated by a high number of necrotic placentas with massive lymphocyte infiltrations at gestational day 18. Surviving fetuses and their placentas from AS(-/-) females were smaller. High-salt diet before and during pregnancy increased systolic blood pressure only before pregnancy in both genotypes and abolished the difference in blood pressure during late pregnancy. Litter size from AS(-/-) was slightly improved and the differences in placental and fetal weights between AS(+/+) and AS(-/-) mothers disappeared. Overall, an increased placental efficiency was observed in both groups paralleled by a normalization of elevated HIF1 levels in the AS(-/-) placentas. Our results demonstrate that aldosterone deficiency has profound adverse effects on placental function. High dietary salt intake improved placental function. In this animal model, aldosterone deficiency did not cause preeclampsia. ABSTRACTCirculating aldosterone levels are increased in human pregnancy. Inadequately low aldosterone levels as present in preeclampsia, a life-threatening disease for both mother and child, are discussed to be involved in its pathogenesis or severity.Moreover, inactivating polymorphisms in the aldosterone synthase gene have been detected in preeclamptic women. Here, we used aldosterone synthase deficient

show abstract

“…Recent work has investigated the role of aldosterone on ERK1/2 signalling in vivo. Dosing new born rats with the MR antagonist spironolactone for 7 days resulted in an increase in apoptosis detected in kidney sections [15]. This observation suggests that at least in juvenile animals, aldosterone plays a role in inhibiting apoptosis.…”

Section: Aldosterone-induced Signalling and Renal Cell Growthmentioning

confidence: 80%

“…MR antagonism resulted in a significant reduction in ERK1/2 and p38 MAP kinase protein expression but a slight increase in the abundance of the mRNA of these two kinases. Conversely JNK-2 expression was induced by spironolactone in the cells of the glomeruli and in the cortical tubules [15]. A role for aldosterone in regulating apoptosis in the adult kidney has also been described.…”

Section: Aldosterone-induced Signalling and Renal Cell Growthmentioning

confidence: 99%