Alginate-based materials for enzyme encapsulation

Weng, Yilun; Yang, Guangze; Li, Yang; Xu, Letao; Chen, Xiaojing; Song, Hao; Zhao, Chun‐Xia

doi:10.1016/j.cis.2023.102957

Cited by 31 publications

(6 citation statements)

References 142 publications

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“…Physical adsorption on the solid support including entrapment in the polymer gels (Figure 4B) or in the polyelectrolyte complexes makes it possible to preserve the native structure of an enzyme globule and its affinity toward inhibitors. Polyurethane [56], polyaniline [57][58][59], polypyrrole [60], polysiloxanes [61], sodium alginate [62], poly(vinyl acetate) photocurable polymer (PVA-SbQ) [63] and bovine serum albumin (BSA) [64] were used for this purpose.…”

Section: Cholinesterase Immobilizationmentioning

confidence: 99%

Electrochemical Acetylcholinesterase Sensors for Anti-Alzheimer’s Disease Drug Determination

Ivanov,

Shamagsumova,

Larina

et al. 2024

Biosensors

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Neurodegenerative diseases and Alzheimer’s disease (AD), as one of the most common causes of dementia, result in progressive losses of cholinergic neurons and a reduction in the presynaptic markers of the cholinergic system. These consequences can be compensated by the inhibition of acetylcholinesterase (AChE) followed by a decrease in the rate of acetylcholine hydrolysis. For this reason, anticholinesterase drugs with reversible inhibition effects are applied for the administration of neurodegenerative diseases. Their overdosage, variation in efficiency and recommendation of an individual daily dose require simple and reliable measurement devices capable of the assessment of the drug concentration in biological fluids and medications. In this review, the performance of electrochemical biosensors utilizing immobilized cholinesterases is considered to show their advantages and drawbacks in the determination of anticholinesterase drugs. In addition, common drugs applied in treating neurodegenerative diseases are briefly characterized. The immobilization of enzymes, nature of the signal recorded and its dependence on the transducer modification are considered and the analytical characteristics of appropriate biosensors are summarized for donepezil, huperzine A, rivastigmine, eserine and galantamine as common anti-dementia drugs. Finally, the prospects for the application of AChE-based biosensors in clinical practice are discussed.

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Section: Cholinesterase Immobilizationmentioning

confidence: 99%

Electrochemical Acetylcholinesterase Sensors for Anti-Alzheimer’s Disease Drug Determination

Ivanov,

Shamagsumova,

Larina

et al. 2024

Biosensors

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“…Found in the cell walls of brown seaweed, it is a linear polysaccharide made up of beta-D-manuronic acid (M) and alpha-L-guluronic acid (G) residues [ 50 ]. High-G-content alginates have been demonstrated to have superior compatibility, making them ideal for applications involving cell encapsulation [ 51 ]. This type of gum dissolves in both warm and cold water, and when it reacts with acids or calcium salts, it creates permanent gels.…”

Section: Natural Polymers Used For Encapsulationmentioning

confidence: 99%

Natural Polymers as Carriers for Encapsulation of Volatile Oils: Applications and Perspectives in Food Products

Tița,

Constantinescu,

Rusu

et al. 2024

Polymers

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The technique of encapsulating different materials into matrices that can both protect and release their contents under specific circumstances is known as encapsulation. It serves the primary function of shielding delicate components from outside influences, including heat, light, and humidity. This can be accomplished by a variety of procedures that, depending on the method and materials selected, result in the creation of particles with various structures. The materials used for encapsulation in food applications must be of high quality, acceptable for human consumption, and stable during processing and storage. The most suitable natural polymers for food applications are carbohydrates, proteins, or mixtures thereof. Volatile oils are end products of plant metabolism, accumulated and stored in various plant organs, cells, or secretory tissues. These are natural and are characterized by the scent of the aromatic plants they come from. Because of their antibacterial and antioxidant qualities, they are being utilized more and more in the food and pharmaceutical industries. Since volatile oils are highly sensitive to environmental changes, they must be stored under specific conditions after being extracted from a variety of plant sources. A promising method for increasing the applicability of volatile oils is their encapsulation into colloidal particles by natural polymers such as carbohydrates and proteins. Encapsulation hides the unfavorable taste of nutrients while shielding delicate dietary ingredients from the effects of heat, moisture, oxygen, and pH. This technique results in improved stability for volatile oils that are often sensitive to environmental factors and offers the possibility of using them in an aqueous system even if they are insoluble in water. This paper aims to provide an overview of the current advances in volatile oil encapsulation technologies and presents a variety of natural polymers used in the food industry for encapsulation. Also, a distinct section is created to highlight the current advances in dairy products enriched with encapsulated volatile oils.

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“…The remarkable ability of drug-containing nanoparticles (IRT-P-HA-NP) to target tumours resulted in a considerable reduction in the growth of malignancies while causing no damage to the body as a whole. Cy5.5-P-HA-NPs are a potential tool for concurrently analysing many aspects of the healing process [27].…”

Section: Diagnostic Detection and Imaging Applications Of Biopolymeri...mentioning

confidence: 99%

Recent Advances in Micro- and Nano-Drug Delivery Systems Based on Natural and Synthetic Biomaterials

Harun-Or-Rashid,

Aktar,

Hossain

et al. 2023

Polymers

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Polymeric drug delivery technology, which allows for medicinal ingredients to enter a cell more easily, has advanced considerably in recent decades. Innovative medication delivery strategies use biodegradable and bio-reducible polymers, and progress in the field has been accelerated by future possible research applications. Natural polymers utilized in polymeric drug delivery systems include arginine, chitosan, dextrin, polysaccharides, poly(glycolic acid), poly(lactic acid), and hyaluronic acid. Additionally, poly(2-hydroxyethyl methacrylate), poly(N-isopropyl acrylamide), poly(ethylenimine), dendritic polymers, biodegradable polymers, and bioabsorbable polymers as well as biomimetic and bio-related polymeric systems and drug-free macromolecular therapies have been employed in polymeric drug delivery. Different synthetic and natural biomaterials are in the clinical phase to mitigate different diseases. Drug delivery methods using natural and synthetic polymers are becoming increasingly common in the pharmaceutical industry, with biocompatible and bio-related copolymers and dendrimers having helped cure cancer as drug delivery systems. This review discusses all the above components and how, by combining synthetic and biological approaches, micro- and nano-drug delivery systems can result in revolutionary polymeric drug and gene delivery devices.

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Alginate-based materials for enzyme encapsulation

Cited by 31 publications

References 142 publications

Electrochemical Acetylcholinesterase Sensors for Anti-Alzheimer’s Disease Drug Determination

Electrochemical Acetylcholinesterase Sensors for Anti-Alzheimer’s Disease Drug Determination

Natural Polymers as Carriers for Encapsulation of Volatile Oils: Applications and Perspectives in Food Products

Recent Advances in Micro- and Nano-Drug Delivery Systems Based on Natural and Synthetic Biomaterials

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