Alginate Based Micelle in Biomedical Applications

Sarika, P.R.; James, Nirmala Rachel

doi:10.1007/978-981-19-6937-9_7

Cited by 1 publication

(1 citation statement)

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“…[90] In addition to cations, sodium alginate can be self-assembled with other cationic polymers such as Eudragit E100 (pKa = 7.0-7.3) and poly-L-lysine (pKa = 9-10.5) to form multiionic complex NCs. [91] At the pH 7.4, ionic interactions occur between the ─COO − of negatively charged alginate and the ─NH 3 + of positively charged 𝜖-polylysine. By this ionic complex SA, the 133 nm NCs can be constructed.…”

Section: Sa Mechanism Of Polysaccharide Moleculesmentioning

confidence: 99%

Self‐Assembled Nanocarrier Delivery Systems for Bioactive Compounds

Zhang,

Ding

et al. 2024

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Although bioactive compounds (BCs) have many important functions, their applications are greatly limited due to their own defects. The development of nanocarriers (NCs) technology has gradually overcome the defects of BCs. NCs are equally important as BCs to some extent. Self‐assembly (SA) methods to build NCs have many advantages than chemical methods, and SA has significant impact on the structure and function of NCs. However, the relationship among SA mechanism, structure, and function has not been given enough attention. Therefore, from the perspective of bottom‐up building mechanism, the concept of SA‐structure‐function of NCs is emphasized to promote the development of SA‐based NCs. First, the conditions and forces for occurring SA are introduced, and then the SA basis and molecular mechanism of protein, polysaccharide, and lipid are summarized. Then, varieties of the structures formed based on SA are introduced in detail. Finally, facing the defects of BCs and how to be well solved by NCs are also elaborated. This review attempts to describe the great significance of constructing artificial NCs to deliver BCs from the aspects of SA‐structure‐function, so as to promote the development of SA‐based NCs and the wide application of BCs.

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Section: Sa Mechanism Of Polysaccharide Moleculesmentioning

confidence: 99%