Alginate-chitosan Coated Lecithin Core Shell Nanoparticles for Curcumin: Effect of Surface Charge on Release Properties and Biological Activities

Pathak, L C; Amrutanand, Tripathy; Agrawal, Y. K.

doi:10.5530/ijper.51.2.32

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…Three separate reported methods [20][21][22] (with a minor modification) were used to prepare CTS. Briefly, In the first method, chitosan was dissolved in 1 % acetic acid.…”

Section: Preparation Of Chitosan Nanoparticles (Cts)mentioning

confidence: 99%

Antimicrobial and Hepatoprotective Effect of Chitosan Nanoparticles In-vitro and In-vivo Study

El-Shafei

Asaad

Elkhateeb

et al. 2021

JPRI

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Nanotechnology has become an extensive area of study due to the peculiar properties of nanoparticles. Chitosan is considered the most promising material for future applications. The purpose of this study was to highlight the antimicrobial and hepatoprotective properties of Chitosan nanoparticles (CTS), as well as their efficacy against multidrug-resistant pathogens and various applications as a natural antioxidant in the biomedical field. CTS were prepared with or without surfactant (L—lecithin, Tween 80) based on inotropic gelation of chitosan with sodium alginate. The nanoparticle obtained displayed a spherical shape with a particle size ranging from 54.3±20.8 to 1256±16.8 nm, zeta potential ranging from 24±1.2 to 30.8±1.1 mV, and polydispersity index ranging from 0.274±0.09 to 0.553±0.06. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) calculations were used to evaluate the antibacterial activity of CTS against four human pathogens: Bacillus subtilis ATCC6633, Staphylococcus aureus NRRLB-767, Escherichia coli ATCC25955, and Pseudomonas aeruginosa ATCC101455. The MIC values were 156.3, 39.4, 78.1, and 78.1 ug/mL, while the MBC values were 500,156.3, 312.5, and 312.5 ug/mL, respectively. S.aureus was the most susceptible, while B. subtilis was the most resistant. The hepatoprotective effect was determined by measuring antioxidant, antiapoptotic, and inflammatory biomarkers, histopathological and immunohistochemical studies. Hepatoprotective results showed a remarkable ameliorative effect against hepatotoxicity induced by CCl4.

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“…Three separate reported methods [20][21][22] (with a minor modification) were used to prepare CTS. Briefly, In the first method, chitosan was dissolved in 1 % acetic acid.…”

Section: Preparation Of Chitosan Nanoparticles (Cts)mentioning

confidence: 99%

Antimicrobial and Hepatoprotective Effect of Chitosan Nanoparticles In-vitro and In-vivo Study

El-Shafei

Asaad

Elkhateeb

et al. 2021

JPRI

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“…One of the compounds of interest is curcumin, which is present in the perennial herb Curcuma longa L. Curcumin is a polyphenol that shows several bioactive properties, such as antimicrobial, anti-inflammatory, and antioxidant properties, and also presents the ability to control the proliferation of a broad variety of tumor cells [ 7 ]. One main barrier to the bioavailability of curcumin is its poor water-solubility (hydrophobic) and fast metabolism [ 8 ]. Curcumin is soluble in ethanol, dimethyl sulfoxide, and acetone.…”

Section: Introductionmentioning

confidence: 99%

Active Carboxymethylcellulose-Based Edible Films: Influence of Free and Encapsulated Curcumin on Films’ Properties

Bourbon

Costa

Maciel

et al. 2021

Foods

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Carboxymethylcellulose (CMC)-based films can act as a protective barrier in food surfaces and a carrier of bioactive compounds, such as curcumin. However, incorporating curcumin in hydrophilic matrixes can be a challenge, and new strategies need to be explored. In this work, CMC-based films containing free curcumin and curcumin-loaded nanohydrogels (composed of lactoferrin and glycomacropeptide) were produced and characterized. The incorporation of curcumin-loaded nanohydrogels showed a significant decrease in films’ thickness (from 0.0791 to 0.029 mm). Furthermore, the water vapor permeability of CMC-based films was significantly decreased (62%) by incorporating curcumin-loaded nanohydrogels in the films. The water affinity’s properties (moisture, solubility, and contact angle) of films were also affected by incorporating encapsulated curcumin. The addition of nanohydrogels to CMC-based films reduced the tensile strength values from 16.46 to 9.87 MPa. Chemical interactions were analyzed using Fourier transform infrared spectroscopy. The release profile of curcumin from CMC-based films was evaluated at 25 °C using a hydrophilic food simulant and suggests that the release mechanism of the curcumin happens by Fick’s diffusion and Case II transport. Results showed that protein-based nanohydrogels can be a good strategy for incorporating curcumin in edible films, highlighting their potential for use in food applications.

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Alginate nanoparticles containing Lavandula angustifolia essential oil as a potential potent, biocompatible and low-cost antitumor agent

et al. 2023

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Alginate-chitosan Coated Lecithin Core Shell Nanoparticles for Curcumin: Effect of Surface Charge on Release Properties and Biological Activities

Cited by 6 publications

References 24 publications

Antimicrobial and Hepatoprotective Effect of Chitosan Nanoparticles In-vitro and In-vivo Study

Antimicrobial and Hepatoprotective Effect of Chitosan Nanoparticles In-vitro and In-vivo Study

Active Carboxymethylcellulose-Based Edible Films: Influence of Free and Encapsulated Curcumin on Films’ Properties

Alginate nanoparticles containing Lavandula angustifolia essential oil as a potential potent, biocompatible and low-cost antitumor agent

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