Alginate Containing Nanoarchitectonics for Improved Cancer Therapy

Giri, Tapan Kumar

doi:10.1016/b978-0-323-47347-7.00020-3

Cited by 19 publications

(12 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ionic gelation technique is based on the capability of polymers to crosslink in the presence of counter ions (Giri et al, 2013). This technique emerged as one of the most promising systems for preparing natural polymers (chitosan/alginate) that are non-toxic, biocompatible, and biodegradable (Giri, 2016). Several studies have been detailed the potential and use of natural polymer (chitosan/alginate) nanoparticles for oral delivery of curcumin based on this method (Bhunchu et al, 2015;Bhunchu et al, 2016).…”

Section: Techniques For Synthesis Of Curcumin Nanoformulationmentioning

confidence: 99%

Nanocurcumin: A Promising Candidate for Therapeutic Applications

2020

View full text Add to dashboard Cite

Section: Techniques For Synthesis Of Curcumin Nanoformulationmentioning

confidence: 99%

Nanocurcumin: A Promising Candidate for Therapeutic Applications

2020

View full text Add to dashboard Cite

“…Furthermore, the bioavailability of drugs formulated in beads has been enhanced. Numerous studies have been reported concerning the use of alginate beads as a controlled release carrier 14,15,16,17 .…”

Section: Multiple Unit Dosage Forms Used In the Drugmentioning

confidence: 99%

Untitled

2021

IJPSR

View full text Add to dashboard Cite

“…Since alginate possesses biocompatibility, low toxicity, biodegradability and superior gelling properties, this polyanionic copolymer of 1–4 linked β- d -mannuronic acid and α- l -glucuronic acid extracted from brown algae or bacteria, whose gel is mainly formed by ionic gelation, is frequently applied for cells and enzyme confinement [ 134 , 135 , 136 , 137 , 138 , 139 ]. Ashok and Devarai [ 88 ] produced ASNase from Rhizopus microsporus IBBL-2 through microencapsulation into Ca-alginate beads, reaching after 48 h an enzymatic activity of 17.68 U mL −1 (TS).…”

Section: Types Of Asnase Confinementmentioning

confidence: 99%

Recent Strategies and Applications for l-Asparaginase Confinement

et al. 2020

View full text Add to dashboard Cite

l-asparaginase (ASNase, EC 3.5.1.1) is an aminohydrolase enzyme with important uses in the therapeutic/pharmaceutical and food industries. Its main applications are as an anticancer drug, mostly for acute lymphoblastic leukaemia (ALL) treatment, and in acrylamide reduction when starch-rich foods are cooked at temperatures above 100 °C. Its use as a biosensor for asparagine in both industries has also been reported. However, there are certain challenges associated with ASNase applications. Depending on the ASNase source, the major challenges of its pharmaceutical application are the hypersensitivity reactions that it causes in ALL patients and its short half-life and fast plasma clearance in the blood system by native proteases. In addition, ASNase is generally unstable and it is a thermolabile enzyme, which also hinders its application in the food sector. These drawbacks have been overcome by the ASNase confinement in different (nano)materials through distinct techniques, such as physical adsorption, covalent attachment and entrapment. Overall, this review describes the most recent strategies reported for ASNase confinement in numerous (nano)materials, highlighting its improved properties, especially specificity, half-life enhancement and thermal and operational stability improvement, allowing its reuse, increased proteolysis resistance and immunogenicity elimination. The most recent applications of confined ASNase in nanomaterials are reviewed for the first time, simultaneously providing prospects in the described fields of application.

show abstract

Alginate Containing Nanoarchitectonics for Improved Cancer Therapy

Cited by 19 publications

References 88 publications

Nanocurcumin: A Promising Candidate for Therapeutic Applications

Nanocurcumin: A Promising Candidate for Therapeutic Applications

Untitled

Recent Strategies and Applications for l-Asparaginase Confinement

Contact Info

Product

Resources

About