Alginate microbeads with internal microvoids for the sustained release of drugs

Boi, Stefania; Rouatbi, Nadia; Dellacasa, Elena; Lisa, Donatella Di; Bianchini, Paolo; Monticelli, Orietta; Pastorino, Laura

doi:10.1016/j.ijbiomac.2020.04.083

Cited by 41 publications

(29 citation statements)

References 56 publications

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“…Boi et al designed and developed alginate microbeads for loading doxorubicin to control its release rate and reduce its toxicity. 40 Meng et al designed and developed a quaternized pectinmontmorillonite hybrid lm to delay the release of 5-FU, which can improve the problem of dosing frequency due to short halflife. 41 From our research, we found that the introduction of groups has a certain effect on the drug-release rate of MOF-based drug delivery systems.…”

Section: Discussionmentioning

confidence: 99%

Functionalization of MOF-5 with mono-substituents: effects on drug delivery behavior

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Functionalization of MOF-5 with mono-substituents: effects on drug delivery behavior

et al. 2020

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“…Additionally, Xie et al demonstrate a simple method for fabricating biodegradable PLA-SC porous scaffolds by solution casting of salt-embedding PLLA/PDLA blend, in which the salt particles (sodium chloride) are served as pore-forming agents by leaching. The obtained foam shows an improved thermal stability with a high structural intergrity even at elevated temperatures (∼120 • C) due to the presence of PLA-SCs (Boi et al, 2019a). It is also very important to point out that these solution-based processing methods lead to additional environmental and safety concerns due to the requirement of using large amounts of volatile and toxic organics solvents, so more environmentally friendly solvents such as supercritical fluid should be considered in the future (Cui et al, 2013).…”

Section: Solution Castingmentioning

confidence: 99%

Recent Progress in Enhancing Poly(Lactic Acid) Stereocomplex Formation for Material Property Improvement

et al. 2020

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The production and utilization of polymers have been widely implemented into diverse applications that benefit modern human society, but one of the most valuable properties of polymers, durability, has posed a long-standing environmental challenge from its inception since plastic waste can lead to significant contamination and remains in landfills and oceans for at least hundreds of years. Poly(lactic acid) (PLA) derived from renewable resources provides a sustainable alternative to traditional polymers due to its advantages of comparable mechanical properties with common plastics and biodegradability. However, the poor thermal and hydrolytic stability of PLA-based materials limit their potential for durable applications. Stereocomplex crystallization of enantiomeric poly (l-lactide) (PLLA) and poly (d-lactide) (PDLA) provides a robust approach to significantly enhance material properties such as stability and biocompatibility through strong intermolecular interactions between L-lactyl and D-lactyl units, which has been the key strategy to further PLA applications. This review focuses on discussing recent progress in the development of processing strategies for enhancing the formation of stereocomplexes within PLA materials, including thermal processing, additive manufacturing, and solution casting. The mechanism for enhancing SC formation and resulting material property improvement enabled by each method are also discussed. Finally, we also provide the perspectives on current challenges and opportunities for improving the understanding of processing-structure-property relationship in PLA materials that could be beneficial to their wide practical applications for a sustainable society.

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“…As an attractive drug carrier for the CsA crystal delivery system, alginate-based microparticles have gained momentum given the favorable characteristics of alginate, including low toxicity, biodegradability, relatively low cost, and gel-forming ability [ 22 ]. In addition, especially for alginate microparticles fabricated by ionic gelation, suitable carriers are available for encapsulating nano- or micro-sized drug particles, proteins, and probiotics.…”

Section: Introductionmentioning

confidence: 99%

pH-Responsive Alginate-Based Microparticles for Colon-Targeted Delivery of Pure Cyclosporine A Crystals to Treat Ulcerative Colitis

et al. 2021

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Cyclosporine A (CsA) is a potent immunosuppressant for treating ulcerative colitis (UC). However, owing to severe systemic side effects, CsA application in UC therapy remains limited. Herein, a colon-targeted drug delivery system consisting of CsA crystals (CsAc)-loaded, Eudragit S 100 (ES)-coated alginate microparticles (CsAc-EAMPs) was established to minimize systemic side effects and enhance the therapeutic efficacy of CsA. Homogeneously-sized CsAs (3.1 ± 0.9 μm) were prepared by anti-solvent precipitation, followed by the fabrication of 47.1 ± 6.5 μm-sized CsAc-EAMPs via ionic gelation and ES coating. CsAc-EAMPs exhibited a high drug loading capacity (48 ± 5%) and a CsA encapsulation efficacy of 77 ± 9%. The in vitro drug release study revealed that CsA release from CsAc-EAMPs was suppressed under conditions simulating the stomach and small intestine, resulting in minimized systemic absorption and side effects. Following exposure to the simulated colon conditions, along with ES dissolution and disintegration of alginate microparticles, CsA was released from CsAc-EAMPs, exhibiting a sustained-release profile for up to 24 h after administration. Given the effective colonic delivery of CsA molecules, CsAc-EAMPs conferred enhanced anti-inflammatory activity in mouse model of dextran sulfate sodium (DSS)-induced colitis. These findings suggest that CsAc-EAMPs is a promising drug delivery system for treating UC.

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Alginate microbeads with internal microvoids for the sustained release of drugs

Cited by 41 publications

References 56 publications

Functionalization of MOF-5 with mono-substituents: effects on drug delivery behavior

Functionalization of MOF-5 with mono-substituents: effects on drug delivery behavior

Recent Progress in Enhancing Poly(Lactic Acid) Stereocomplex Formation for Material Property Improvement

pH-Responsive Alginate-Based Microparticles for Colon-Targeted Delivery of Pure Cyclosporine A Crystals to Treat Ulcerative Colitis

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