Alginate microsphere filled with carbon nanotube as drug carrier

Zhang, Xiaolan; Hui, Zhongying; Wan, Daxin; Huang, Haitao; Huang, Jin; Yuan, Hong; Yu, Jiahui

doi:10.1016/j.ijbiomac.2010.06.003

Cited by 85 publications

(37 citation statements)

References 40 publications

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“…This finding was in close agreement with the results obtained by Zhang et al (2010) for theophylline. As per literature review, hydrophobic interaction and pore size of the nanometer scale of MWCNTs make it difficult for the dissolution medium to penetrate inside the matrix of microspheres.…”

Section: Dissolution Studiessupporting

confidence: 93%

Enhanced encapsulation of metoprolol tartrate with carbon nanotubes as adsorbent

Garala

Patel

Patel³

et al. 2011

Appl Nanosci

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A highly water-soluble antihypertensive drug, metoprolol tartrate (MT), was selected as a model drug for preparation of multi-walled carbon nanotubes (MWCNTs)-impregnated ethyl cellulose (EC) microspheres. The present investigation was aimed to increase encapsulation efficiency of MT with excellent adsorbent properties of MWCNTs. The unique surface area, stiffness, strength and resilience of MWCNTs have drawn much anticipation as carrier for highly water-soluble drugs. Carbon nanotubes drug adsorbate (MWCNTs:MT)-loaded EC microspheres were further optimized by the central composite design of the experiment. The effects of independent variables (MWCNTs:MT and EC:adsorbate) were evaluated on responses like entrapment efficiency (EE) and t 50 (time required for 50% drug release). The optimized batch was compared with drug alone EC microspheres. The results revealed high degree of improvement in encapsulation efficiency for MWCNTs:MT-loaded EC microspheres. In vitro drug release study exhibited complete release form drug alone microspheres within 15 h, while by the same time only 50-60% drug was released for MWCNTsimpregnated EC microspheres. The optimized batch was further characterized by various instrumental analyses such as scanning electron microscopy, powder X-ray diffraction and differential scanning calorimetry. The results endorse encapsulation of MWCNTs:MT adsorbate inside the matrix of EC microspheres, which might have resulted in enhanced encapsulation and sustained effect of MT. Hence, MWCNTs can be utilized as novel carriers for extended drug release and enhanced encapsulation of highly watersoluble drug, MT.

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Section: Dissolution Studiessupporting

confidence: 93%

Enhanced encapsulation of metoprolol tartrate with carbon nanotubes as adsorbent

Garala

Patel

Patel³

et al. 2011

Appl Nanosci

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“…In addition, due to the mild gelation process within the matrix and the high biocompatibility, alginate is well suited to form the matrix for the microencapsulation of various drugs. In previous works, we have explored pH-sensitive alginate/soy protein [5], alginate/carbon nanotube nanocomposite microspheres [6], and alginate-based magnetic microspheres [7] as drug transporters, which showed obvious differences in swelling and drug release. Because of the limited mechanical stability, durability, and high-diffusion rates resulting from the high porosity [8] (which results in low encapsulation efficiency and limited control over the kinetics of drug release) the practical applications of alginate as a drug delivery system are hindered.…”

Section: Introductionmentioning

confidence: 99%

Effect of polysaccharide nanocrystals on structure, properties, and drug release kinetics of alginate-based microspheres

Lin

Huang

Chang

et al. 2011

Colloids and Surfaces B: Biointerfaces

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196

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“…Theophylline was encapsulated in a CNT-filled alginate (AL) microsphere [88]. The drug leakage decreases when AL/ CNT microsphere is used in comparison to AL microsphere.…”

mentioning

confidence: 99%

Delivery of drugs and biomolecules using carbon nanotubes

Vashist

Zheng

Pastorin

et al. 2011

Carbon

253

127

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Carbon nanotubes (CNTs) have emerged as one of the most advanced nanovectors for the highly efficient delivery of drugs and biomolecules. They offer several appealing features such as large surface areas with well defined physico-chemical properties as well as unique optical and electrical properties. They can be conjugated non-covalently or covalently with drugs, biomolecules and nanoparticles. Albeit some pending concerns about their toxicity in vitro and in vivo, functionalized CNTs appear to exhibit very low toxicity and are not immunogenic. Thus, they could be promising carriers with a great potential for the development of a new-generation delivery system for drugs and biomolecules. There have been significant advances in the field of CNT-based drug delivery, especially in the specific targeting of anticancer and anti-inflammatory drugs for tissues and organs in the body, where their therapeutic effect is highly required. Other promising applications are the delivery of DNA, RNA and proteins.Crown

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Alginate microsphere filled with carbon nanotube as drug carrier

Cited by 85 publications

References 40 publications

Enhanced encapsulation of metoprolol tartrate with carbon nanotubes as adsorbent

Enhanced encapsulation of metoprolol tartrate with carbon nanotubes as adsorbent

Effect of polysaccharide nanocrystals on structure, properties, and drug release kinetics of alginate-based microspheres

Delivery of drugs and biomolecules using carbon nanotubes

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