Alginate–montmorillonite composite systems as sustained drug delivery carriers

Das, Sukhen; Pattanayak, Dharmajit; Nayak, Amit Kumar; Yi, Dong Kee; Nanda, Sitansu Sekhar; Ansari, Mohammed T; Hasnain, Saquib

doi:10.1016/b978-0-12-817640-5.00008-x

Cited by 6 publications

(1 citation statement)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increase in content of phenols and flavonoids was due to an increase in extractability of bound phenols by pyrolysis of cellular components [ 39 ]. This is similar to a previous report showing that the bioavailability of phenolic acid is increased when the particle size is reduced by mechanical treatment [ 40 , 41 ]. Additionally, samples prepared using the extrusion molding process showed increased contents of C3G and C3R (ACNs of mulberry) released into the solution.…”

Section: Resultssupporting

confidence: 92%

Hot-Melt Extrusion Enhances Antioxidant Effects of Mulberry on Probiotics and Pathogenic Microorganisms

Ryu²,

Gim³

et al. 2022

Antioxidants

View full text Add to dashboard Cite

Mulberry is a rich source of anthocyanins (ACNs) known to possess biological activities. However, these ACNs are unstable in high pH, heat, and aqueous environments with a low bioavailability. In this study, a colloidal dispersion was prepared by hot melt extrusion with proper excipients. In this process, a hydrophilic polymer matrix was used to confirm the stability of the compound in high pH, high temperature, and aqueous media. It was confirmed that the particle size and the polydispersity index value were reduced, thereby improving the solubility. In vitro release studies revealed that the extrudate had a sustained release compared to a non-extruded product. As a result of measuring changes of intestinal microorganisms (Lacticaseibacillus rhamnosus, Pediococcus pentosaceus, Escherichia coli, Enterococcus faecalis, and Staphylococcus aureus), contents of probiotics were found to be increased whereas contents of pathogenic microorganisms were decreased. Thus, hot-melt extrusion could enhance the stability of ACN with prolonged release. The processed formulation exhibited probiotic properties and antimicrobial activities against pathogenic intestinal microflora.

show abstract

Section: Resultssupporting

confidence: 92%