Aliskiren

Abstract

Aliskiren at a dosage of 150 or 300 mg daily may be a good option for control of mild-to-moderate hypertension in patients with or without diabetes in whom first-line antihypertensives have failed to adequately control BP; comparative studies with other antihypertensives are needed to determine which patients can most benefit from aliskiren therapy.

Pharmacokinetics, Pharmacodynamics, and Tolerability of ACT-077825, a New Direct Renin Inhibitor After Multiple-ascending Doses in Healthy Subjects

“…On these 2 days, 24 hours after treatment, the effects of ACT-077825 on AR levels were still present supporting the notion that a once-daily dosing regimen would result in RAAS disruption beyond 24 hours similar to that observed with aliskiren. 15,17,18 In agreement with our previous single-ascending dose study, 12 this reactive rise in AR demonstrates that, like the ACEI enalapril and other RIs, 1,8 treatment with ACT-077825 suppresses the RAAS activity and more particularly disrupts the negative feedback loop exerted by ANGII 8 on renin secretion. In agreement with its direct RI properties, ACT-077825 inhibited PRA.…”

Antihypertensive Drugs

“…This new way of blocking the reninangiotensin-aldosterone system provides a unique opportunity to block the renin-angiotensin system at its initial step was very promising as it aliskiren (22.4.82) was proposed [160][161][162][163][164][165][166][167] (Fig. 22.9.…”

A Validated Stability Indicating RP-HPLC Method Development and Validation for Simultaneous Estimation of Aliskiren Hemifumarate and Amlodipine Besylate in Pharmaceutical Dosage Form

“…The chromatographic separation of analytes was carried out using waters 2695 RP-HPLC system with C-8 Inertsil ODS (150 × 4.6 mm, 5 ) column. The mobile phase consists of phosphate buffer and acetonitrile in the ration of 40 : 60% v/v and pH was adjusted to 3 with orthophosphoric acid solution that was used to separate the analytes and column temperature was maintained at 30 ∘ C. The analytes were detected at 237 nm using PDA detector.…”

“…Renin is secreted by the kidney, which cleaves the angiotensinogen to form angiotensin I and is then converted into angiotensin II by angiotensinogen converting enzyme. Aliskiren inhibits the catalytic activity of rennin system and inhibits the generation of angiotensin I and angiotensin II [5][6][7].…”