Aliskiren affects fatty-acid uptake and lipid-related genes in rodent and human cardiomyocytes

Rodríguez-Penas, Diego; Feijóo‐Bandín, Sandra; Lear, Pamela; Mosquera-Leal, Ana; García-Rúa, Vanessa; Otero, Manuel; Rivera, Miguel; Gualillo, Oreste; González-Juanatey, José Ramón; Lago, Francisca

doi:10.1016/j.bcp.2011.05.021

Cited by 5 publications

(3 citation statements)

References 87 publications

(120 reference statements)

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“…Meanwhile, microarray analysis of the complete genome of aliskiren-treated neonatal-rat cardiomyocytes, with RT-qPCR and immunoblot confirmation assays in rat and human primary cardiomyocytes, revealed that aliskiren upregulated mRNA and increased protein expression of several enzymes that play an important role in cholesterol breakdown [31].…”

Section: Discussionmentioning

confidence: 99%

Aliskiren Protects against Hypercholesterolemia and Oxidative Stress on Isolated Aortae in Cholesterol-Fed Rats

Kamal¹

2011

J Nanomedic Nanotechnol

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Background: Atherosclerosis and endothelial dysfunction are important associated disorders in the majority of hypertensive patients. Many studies are directed towards investigating any possible anti-hyperlipidemic effect with improvement of arterial compliance of newer generations of antihypertensive drugs so as to reduce the number of drugs used to treat those patients. Aim:The present study aims to determine the effects of aliskiren, a direct renin inhibitor, on serum cholesterol and some anti-oxidant enzymes together with aortic TBARS and vasorelaxant effect of acetyl-choline (Ach) on isolated aortic rings of cholesterol-fed rats. Methods:The duration of the study was 12 weeks. Twenty-four rats were randomly divided into 3 groups (n=8 rats/ group). Group (1) is control, received 0.5% carboxymethylcellulose (CMC) sodium, as a solvent of aliskiren, and fed ordinary diet. Group (2) fed 2% (w/w) cholesterol diet + CMC sodium. Group (3) was fed with 2% (w/w) cholesterol diet with ip daily administration of aliskiren at a dose of 5 mg/kg for 12 weeks. Systolic blood pressure (SBP) was assessed both at the beginning and at the end of every 4 weeks of the study. Serum total cholesterol, superoxide dismutase (SOD) enzyme in erythrocyte lysates, thiobarbituric acid reactive substance [TBARS] content, activities of catalase and glutathione enzymes in aortic homogenates of tested rats were measured. The thoracic aortae were removed from all tested rats to assess the vasorelaxant effect of Ach.Results: Aliskiren-treated group (3) showed a significant improvement of all the markers in comparison with nontreated cholesterol-fed rats. SBP of treated group was maintained at levels comparable to control group (1) with marked improvement in aortic reactivity to ACh compared to group (2). Conclusion:Aliskiren could possess an anti-hypercholestrolemic and an ability to improve aortic reactivity via an anti-oxidant effect and a reduction in lipid peroxidation in cholesterol-fed rats.

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Section: Discussionmentioning

confidence: 99%

Aliskiren Protects against Hypercholesterolemia and Oxidative Stress on Isolated Aortae in Cholesterol-Fed Rats

Kamal¹

2011

J Nanomedic Nanotechnol

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“…(15,(26)(27)(28) In the present study concentrations of aliskiren in the micromolar range were found to be safe for RPE cells and therefore were used to…”

Section: Discussionmentioning

confidence: 99%

Aliskiren inhibits the renin-angiotensin system in retinal pigment epithelium cells

Simão

Santos

Silva

2016

European Journal of Pharmaceutical Sciences

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“…In our results, DRI reduced the expression of intracellular renin after ischemia in DM heart. Aliskiren has been reported to reduce the gene expression of cardiovascular diseases-related proteins including connective tissue growth factor (CTGF) and tissue growth factor-β (TGF-β) [36,37]. Aliskiren also reduced the gene expression of (pro)renin receptor in the kidney of in vivo diabetic model of mouse-renin expressing rat 2+ (TG(mRen-2)).…”

Section: Renin Contributes To Ischemic Tolerance In Diabetic Heartmentioning

confidence: 99%

Intracellular Renin Protects Cardiomyocytes from Ischemic Injury in Diabetic Heart

Nonaka¹,

Katoh²,

Kumazawa³

et al. 2015

J Cardiovasc Dis Diagn

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prorenin and AGN. Prorenin can be either excreted immediately or converted into renin by proteolytic cleavage of the prosegment [4].The existence of (pro) renin receptor that can bind to both renin and prorenin was reported. The binding to the (pro) renin receptor actives prorenin through the induction of conformational changes of the prosegment [5]. Receptor binding to prorenin/renin also triggers its own intracellular signaling pathways, independently from AngII generation [6].An alternatively spliced renin transcript, which does not encode a secretory signal, was identified, and renin encoded by this transcript had a truncated prosegment, which compromises the secretory signal sequence and remains within the cytosol [7-9]. In the adrenal gland, the non-secreted intracellular renin exists predominantly within mitochondria [10]. The non-secretory renin was also found in cardiomyocytes [7,8]. In H9c2 cells, overexpression of the alternatively spliced renin transcript resulted in the compartmentation of non-

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Aliskiren affects fatty-acid uptake and lipid-related genes in rodent and human cardiomyocytes

Cited by 5 publications

References 87 publications

Aliskiren Protects against Hypercholesterolemia and Oxidative Stress on Isolated Aortae in Cholesterol-Fed Rats

Aliskiren Protects against Hypercholesterolemia and Oxidative Stress on Isolated Aortae in Cholesterol-Fed Rats

Aliskiren inhibits the renin-angiotensin system in retinal pigment epithelium cells

Intracellular Renin Protects Cardiomyocytes from Ischemic Injury in Diabetic Heart

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