ALK-Negative T-Cell Anaplastic Large Cell Lymphoma Associated with Systemic Lupus Erythematosus

Suvajdžić, Nada; Stojanovic-Milenkovic, Roksanda; Tomasevic, Z.; Cemerikic-Martinovic, Vesna; Mihaljević, Biljana; Atkinson, Henry Dushan

doi:10.1385/mo:20:4:409

Cited by 5 publications

(7 citation statements)

References 19 publications

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“… † Other lymphomas reported in patients with systemic lupus erythematosus include: mucosa‐associated lymphoid tissue lymphoma, 134 mycosis fungoides, 135 and T‐cell anaplastic large cell lymphoma 136 …”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

“…Cancers develop in patients with systemic lupus erythematosus (Table 4 128–182 ), and the reported frequency of malignancy in these patients ranges between 2.5% and 13.8% 133,135,137–143,145,153,161,164,174,176–179,183,184 . It is still controversial whether systemic lupus erythematosus is associated with an increased overall risk for cancer.…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

“…Systemic lupus erythematosus patients have an increased risk of developing B‐cell hematologic neoplasias and lymphoproliferative disorders 133,134,136,145,161,169,170,178,185 . The majority of patients are diagnosed with systemic lupus erythematosus before the discovery of these malignancies by several months or years 128,134–136,142,143,146,147,149,152,154,157,159,161,163,165,167,171–173,180–182 . Typically, the two diseases seem to follow independent clinical courses rather than being affected by one another 134,136,164 .…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

“…The majority of patients are diagnosed with systemic lupus erythematosus before the discovery of these malignancies by several months or years 128,134–136,142,143,146,147,149,152,154,157,159,161,163,165,167,171–173,180–182 . Typically, the two diseases seem to follow independent clinical courses rather than being affected by one another 134,136,164 . Infrequently, the diagnosis of malignancy precedes the appearance of systemic lupus erythematosus 134,142,156,158,159,161,185 .…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

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Granuloma annulare, relapsing polychondritis, sarcoidosis, and systemic lupus erythematosus: conditions whose dermatologic manifestations may occur as hematologic malignancy‐associated mucocutaneous paraneoplastic syndromes

Cohen¹

2006

Int J Dermatology

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IntroductionThe appearance of certain dermatoses has heralded either the diagnosis of a previously unsuspected malignancy or the detection of cancer recurrence in an oncology patient. 1,2 These associated mucosal and cutaneous conditions are referred to as mucocutaneous paraneoplastic syndromes. 3 In this issue, Zappasodi et al . 4 review some of the mucocutaneous paraneoplastic syndromes that occur in patients with hematologic malignancies. Albeit less commonly, other dermatologic conditions and systemic disorders can also occur in a paraneoplastic setting associated with hematologic malignancies: granuloma annulare, relapsing polychondritis, sarcoidosis, and systemic lupus erythematosus. Granuloma AnnulareGranuloma annulare is a chronic dermatosis of undetermined etiology. Clinically, the skin lesions present as flesh-colored to red papules and small nodules, which appear either as individual lesions or as an annular arrangement of confluent lesions. Mucin-containing areas of necrobiotic collagen in the dermis are surrounded by palisading granulomas consisting of epithelioid histiocytes, lymphocytes, and multinucleated giant cells.Granuloma annulare can be localized to a specific area of the body or generalized. Perforating and subcutaneous variants of the condition may also occur. Several factors have been described to precipitate the development of granuloma annulare: sunburn, drug eruption, flu-like illness, trauma, insect bites, and acute phlebitis. In addition, granuloma annulare has been observed in patients with potentially associated diseases -particularly diabetes mellitus and thyroid disease, but also drug allergy, hypertension, obesity, arthritis, atopy, sarcoidosis, and human immunodeficiency virus infection. [5][6][7][8][9] Skin lesions of leukemia or lymphoma that histopathologically mimic granuloma annulare have also been described in patients with hematologic malignancies. 10-14 Cancer-associated granuloma annulare has been reported predominantly in patients with hematologic malignancies (most commonly non-Hodgkin's lymphoma and Hodgkin's disease) and, less often, in individuals with solid tumors (Table 1). 5,6,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] Relapsing PolychondritisRelapsing polychondritis is a multisystemic disorder characterized by recurrent inflammation and degeneration of cartilaginous tissues -particularly those of the ears, nose, larynx, and trachea. [34][35][36][37] The dermatologic manifestations of relapsing polychondritis are variable and include aphthosis [oral and complex (genital)], nodules (on the extremities), purpura, papules, sterile pustules, superficial phlebitis, livedo reticularis, ulcers (on the extremities), and distal necrosis. 38 The aorta, bone, bronchi, central nervous system, ears, eyes, genitals, heart valves, kidneys, larynx, mouth, nose, and trachea are potential sites of extracutaneous involvement in patients with relapsing polychondritis. 34,38,39 The diagnostic criteria for relapsing polychondritis were initially e...

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Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

See 2 more Smart Citations

Granuloma annulare, relapsing polychondritis, sarcoidosis, and systemic lupus erythematosus: conditions whose dermatologic manifestations may occur as hematologic malignancy‐associated mucocutaneous paraneoplastic syndromes

Cohen¹

2006

Int J Dermatology

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“…Alternatively, there is an increase in lymphomas in patients with systemic lupus erythematosus, even when they are not treated with immunosuppression. 10 Amyloid in association with systemic lupus erythematosus is quite rare and usually manifests as renal involvement. Fewer than 20 cases have been reported.…”

mentioning

confidence: 99%

Amyloid Mass of the Ciliary Body

Char¹

2006

Arch Ophthalmol

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Autoimmune disorders in patients with T-cell lymphoma: a comprehensive review

Bergh

Alvarez-Argote

Panwala

et al. 2015

Current Medical Research and Opinion

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Autoimmune disorders can develop prior to, during or after the onset of TCL. The diagnosis of TCL should prompt early recognition of certain autoimmune disorders if clinical suspicion exists. A dysfunctional immune response in these patients may be responsible for the occurrence of autoimmunity. Conversely, autoimmune conditions might create a favorable milieu for T-cell lymphoma pathogenesis. Therefore, their presence should increase the suspicion of TCL in an appropriate clinico-laboratory context. There is need for larger studies to assess further the TCL-autoimmunity relationship as prognosis and management of these patients can be considerably affected.

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ALK-Negative T-Cell Anaplastic Large Cell Lymphoma Associated with Systemic Lupus Erythematosus

Cited by 5 publications

References 19 publications

Granuloma annulare, relapsing polychondritis, sarcoidosis, and systemic lupus erythematosus: conditions whose dermatologic manifestations may occur as hematologic malignancy‐associated mucocutaneous paraneoplastic syndromes

Granuloma annulare, relapsing polychondritis, sarcoidosis, and systemic lupus erythematosus: conditions whose dermatologic manifestations may occur as hematologic malignancy‐associated mucocutaneous paraneoplastic syndromes

Amyloid Mass of the Ciliary Body

Autoimmune disorders in patients with T-cell lymphoma: a comprehensive review

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