Alkali Citrate for Preventing Recurrence of Calcium Oxalate Stones

Hauser, W.; Frick, J.G.; Kunit, G.

doi:10.1159/000464049

Cited by 12 publications

(7 citation statements)

References 4 publications

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“…Several commercial juices reportedly could prevent nephrolithiasis, but in our experiment K-citrate alone decreased renal stone crystallization in the Drosophila model. Some investigators have shown that alkalizing fluids and high citric acid excretion could decrease the risk of CaOx stone formation [40]. Yilmaz et al showed that fresh tomato juice may increase the level of urinary citrate, as is the case for orange juice and lemon juice.…”

Section: Discussionmentioning

confidence: 99%

Effects of commercial citrate‐containing juices on urolithiasis in a Drosophila model

Chen

et al. 2013

The Kaohsiung J of Med Scie

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Diet modification plays an important role in nephrolithiasis. Development of an easy, ready-to-use beverage such as a commercial juice drink to use as a preventive treatment for renal calculi formation would be widely welcomed. We previously developed a novel Drosophila model for the study of nephrolithiasis. It provides a new well-established drug discovery platform for this common disease. In our current study, we used the Drosophila model to investigate the preventive effects of various commercial juices as potential treatments for nephrolithiasis. Our results showed that apple, cranberry, orange, and pomegranate juices failed to reduce calcium oxalate (CaOx) crystal formation, whereas our positive control-potassium citrate (K-citrate)-significantly prevented CaOx crystal formation. Unlike the commercial fruit juices that were tested, the administration of K-citrate significantly ameliorated the ethylene glycol (EG)-induced life-span reduction in treated flies. These results indicate that EG-induced CaOx nephrolithiasis in Drosophila can be prevented by K-citrate, but not by commercial citrate-containing juices. However, the inhibitory capability of citrate-containing juices to reduce renal stone formation in humans requires further elucidation.

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Section: Discussionmentioning

confidence: 99%

Effects of commercial citrate‐containing juices on urolithiasis in a Drosophila model

Chen

et al. 2013

The Kaohsiung J of Med Scie

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“…Although such a dose would have been desirable, this regimen is not easily adhered to long-term. It should be noted that the most successful results reported in the literature (3,15,18,19,36) were obtained with a daily citrate dose between 18 and 36 mmol. However, Hofbauer et al did not succeed in preventing stone formation in their patients despite prescribing a daily dosage of 54 mmol (21).…”

Section: Discussionmentioning

confidence: 99%

Long-term Follow-up of Stone Formers Treated with a Low Dose of Sodium Potassium Citrate

Jendle-Bengten

Tiselius

2000

Scandinavian Journal of Urology and Nephrology

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We evaluated the clinical efficacy of long-term preventive treatment with a single evening dose of alkaline citrate. Information was collected from the files of 52 recurrent stone formers prescribed a daily intake of 3.75-5 g of sodium potassium citrate (SPC; 14-18 mmol of citrate). The annual and cumulative rates of stone formation and the rate of recurrence were compared before and during the treatment. A comparison was also made between the patients with (Group R) and without (Group NR) recurrent stone formation during treatment in terms of urine composition and previous history of the disease. For all patients who started the treatment, the number of stones was smaller during treatment (period tT) than during a period of the same length immediately before treatment (period tB), but greater than the number formed during a corresponding period immediately after the diagnosis (period tA). Via questionnaire we found low treatment compliance, with only 62% of the patients reporting consistent taking of their medication (Group T). The patients in Group T had a smaller cumulated number of stones during period tT than that during periods tA and tB, but the Kaplan-Meier curve of the fraction of patients remaining stone-free during treatment was almost identical to that recorded in 446 recurrent stone formers without medical treatment. No significant differences were recorded in terms of relevant pretreatment urinary risk factors between Groups T(R) and T(NR), but numerically higher values of calcium oxalate (CaOx) supersaturation and calcium/citrate quotients were observed in Group T(R). When 9 patients with a daily intake of SPC and a citrate excretion below 2.5 mmol/day were compared with 16 hypocitraturic patients only given drinking advice, the cumulated percentages of patients without recurrent stone formation in the 2 groups after 3 years were 44% and 48%, respectively. Although the number of patients in this study was small, our results indicate poor long-term protection from recurrent calcium stone formation when a single evening dose of only 3.75-5 g of SPC was taken. The rate of stone formation was apparently slightly reduced, but the fraction of patients free of recurrence was no different from that in patients without medical treatment.

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“…Hauser et al [20] untersuchten den klinischen Nutzen einer intermittierenden (2 Wochen Therapie,1 Woche Therapiepause) vs.kontinuierlichen Alkalizitrattherapie mit Natrium-Kalium-Zitrat zur Prä-vention von Steinrezidiven bei rezidivierenden Kalziumoxalatsteinbildnern über einen Zeitraum von 18 Monaten. Sie fanden keine signifikanten Unterschiede.…”

Section: Intervalltherapie Oder Dauermetaphylaxe?unclassified

Alkalizitrate in der Urologie

2004

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Alkaline citrates have been used as an efficient therapy in hypocitraturic calcium nephrolithiasis, uric acid lithiasis, cystinuria, and renal tubular acidosis. Furthermore, alkaline citrates are very effective in treating and preventing hyperchloremic metabolic acidosis in patients with urinary diversion. The main physiological effects during urolithiasis therapy have been significant increases in urinary pH, in citrate and potassium, and a decrease in calcium excretion. This paper reviews current indications, therapy modalities, and metaphylactic use reported in the literature and/or recommended by the Deutsche Gesellschaft für Urologie (DGU) and the European Association of Urology (EAU). It is intended to give useful advice for the urologist's daily practice.

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Alkali Citrate for Preventing Recurrence of Calcium Oxalate Stones

Cited by 12 publications

References 4 publications

Effects of commercial citrate‐containing juices on urolithiasis in a Drosophila model

Effects of commercial citrate‐containing juices on urolithiasis in a Drosophila model

Long-term Follow-up of Stone Formers Treated with a Low Dose of Sodium Potassium Citrate

Alkalizitrate in der Urologie

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