Alkaloids from Melodinus hemsleyanus

Li-wei, Guo; Yun-li, Zhou

doi:10.1016/0031-9422(93)80046-u

Cited by 63 publications

(31 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Substances are separated with liquid chromatography using different solvent mixtures with silica gel [13], charcoal [17] and sephadex [14] [18]. Other types of analytical techniques include thin layer chromatography (TLC) and high performance liquid chromatography (HPLC) [19]- [22].…”

Section: Chemical Constituentsmentioning

confidence: 99%

“…Venalstonine dehydro 14-15 (16), venalstonidine epoxy 14-15α (17), paucivenine (18), pleiomutine (19) [34].…”

Section: Melodinus Balansae Baillmentioning

confidence: 99%

“…A pharmacological test revealed that 11-hydroxyvincadifformine which was isolated from the aerial parts of Melodinus hemsleyanus has significant antifertility activity [19].…”

Section: Other Biological Activitiesmentioning

confidence: 99%

See 2 more Smart Citations

The Genus Melodinus (Apocynaceae): Chemical and Pharmacological Perspectives

Lu¹,

Khoo²,

Wiart³

2014

View full text Add to dashboard Cite

The plants of the genus Melodinus (Apocynaceae) are widely distributed, and have long been used in folk medicine for the treatment of various ailments such as meningitis in children and rheumatic heart diseases, hernia, infantile malnutrition, dyspepsia and testitis. Over 100 alkaloids together with flavonoids, lignans, steroids, terpenoids and coumarins have been identified in the genus, and many of these have been evaluated for biological activity. This review presents comprehensive information on the chemistry and pharmacology of the genus together with the traditional uses of many of its plants. In addition, this review discusses the structure-activity relationship of different compounds as well as recent developments and the scope for future research in this aspect.

show abstract

Section: Chemical Constituentsmentioning

confidence: 99%

“…Venalstonine dehydro 14-15 (16), venalstonidine epoxy 14-15α (17), paucivenine (18), pleiomutine (19) [34].…”

Section: Melodinus Balansae Baillmentioning

confidence: 99%

See 1 more Smart Citation

The Genus Melodinus (Apocynaceae): Chemical and Pharmacological Perspectives

Lu¹,

Khoo²,

Wiart³

2014

View full text Add to dashboard Cite

show abstract

“…[15][16][17][18][19][20][21] Therefore, except the first-type melodan alkaloids, no alkaloid of the plumeran subclass contains the vinyl group in intact form. However, the presence of the 18,19-unsaturation in the previous phases of the biogenesis is strongly supported by the functional groups mentioned above and by further oxygen-containing cycles, which were developed evidently from the vinyl group.…”

Section: Genealogy Of the Melodan Alkaloidsmentioning

confidence: 99%

Molecular interrelations in the Melodinus alkaloids

Szabó

2006

Arkivoc

View full text Add to dashboard Cite

Structural and chemotaxonomical data as well as consideration of standard organic reaction mechanisms provided a coherent picture about the probable formation of the small but characteristic group of Melodinus alkaloids in the plant family Apocynaceae. All 14 alkaloids could be classified into the melodan skeleton and its rearranged version and derived from 18,19-didehydrotabersonine as parent compound.

show abstract

“…Then, this compound and 10-hydroxyscandine (180) [2,15,17,19,25,27,28,29,30,43,46,55,59]. And the absolute configuration has aroused the great concern [60].…”

Section: Monoterpenoid Quinoline Alkaloidsmentioning

confidence: 99%

Phytochemical and Pharmacological Properties of the Genus Melodinus – A Review

Jiang¹,

Zhang²,

Chen³

2016

Trop. J. Pharm Res

View full text Add to dashboard Cite

Melodinus is an important genus comprising of approximately 53 species of medicinal plants (Apocynaceae). Some species have been used in Chinese folk medicine for the treatment of meningitis in children, rheumatic heart diseases, and diuresis, as well as a decongestive against migraine and sinusitis. This paper is a review of the literature up to May 2015 and describes 263 compounds from 69 articles, and includes chemical constituents isolated from Melodinus, mainly indole alkaloids, quinoline alkaloids, dimeric alkaloids, terpenoids and other compounds. It is also hoped that an overview of their cytotoxic characteristics will further the development of new anti-cancer agents.

show abstract

Alkaloids from Melodinus hemsleyanus

Cited by 63 publications

References 3 publications

The Genus Melodinus (Apocynaceae): Chemical and Pharmacological Perspectives

The Genus Melodinus (Apocynaceae): Chemical and Pharmacological Perspectives

Molecular interrelations in the Melodinus alkaloids

Phytochemical and Pharmacological Properties of the Genus Melodinus – A Review

Contact Info

Product

Resources

About