Alkaloids in Diet

Chen, Cheng; Lin, Ligen

doi:10.1007/978-981-15-4148-3_36

Cited by 3 publications

(14 citation statements)

References 34 publications

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“…10 Chinchonine, cinchonidine, quinine, and quinidine are major quinoline alkaloids. 5 Quinine is a quinoline alkaloid that is isolated from the bark of Cinchona species and has antimalarial activity. 9,17 • ing with mACh and 5-HT 2 receptors.…”

Section: • Indole Alkaloidsmentioning

confidence: 99%

“…1 As of now, over 13,000 alkaloids have been discovered, separated, and structurally characterized from different sources of plants. 5 Alkaloids have been discovered to be present in 20% of plant species. Alkaloids have a nitrogen atom and a cyclic structure.…”

Section: Introductionmentioning

confidence: 99%

“…Alkaloids' free bases are prone to be dissolved in non-polar organic solvents such as ether and chloroform, whereas the salt form of alkaloids is readily dissolved in water or weak acids. 5 Generally, alkaloids are bitter in taste and optically active. They are mostly prevalent in plants that belong to the following botanical families: Ranunculaceae, Annonaceae, Papaveraceae, Lauraceae, Berberidaceae, Magnoliaceae, Gnetaceae, Solanaceae, Leguminoceae, Loganiaceae, Boraginaceae, Menispermaceae, Amaryllidaceae, Piperaceae, Rutaceae, Rubiaceae, Apocynaceae, Liliaceae, etc.…”

Section: Introductionmentioning

confidence: 99%

“…1 In 1804, morphine, a potent narcotic used to treat extreme pain, was the first alkaloid to be separated and crystallized from opium poppy plants. 5 Alkaloids have significant physiological effects on humans and are used for their anesthetic, cardio-protective, anti-inflammatory, antifungal, antibacterial, anthelmintic, anticonvulsant, analgesic, antihyperglycemic, hypolipidemic, antitumor, antihistaminic, central nervous system (CNS) stimulant and antidepressant, and antitubercular effects and for the treatment of ocular disorders such as glaucoma. 5,9 Alkaloids are categorized on the basis of their biosynthetic precursor, chemical structure, and nature.…”

Section: Introductionmentioning

confidence: 99%

“…5 Alkaloids have significant physiological effects on humans and are used for their anesthetic, cardio-protective, anti-inflammatory, antifungal, antibacterial, anthelmintic, anticonvulsant, analgesic, antihyperglycemic, hypolipidemic, antitumor, antihistaminic, central nervous system (CNS) stimulant and antidepressant, and antitubercular effects and for the treatment of ocular disorders such as glaucoma. 5,9 Alkaloids are categorized on the basis of their biosynthetic precursor, chemical structure, and nature. Based on their biosynthesis, they are classified into five main classes: the L-tryptophan, L-ornithine, L-tyrosine, L-tyrosine/L-phenylalanine, L-lysine, and glycine/aspartic acid classes.…”

Section: Introductionmentioning

confidence: 99%

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An insight into recent updates on analytical techniques for bioactive alkaloids

Saini,

Seni,

Chawla

et al. 2024

Phytochemical Analysis

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IntroductionAlkaloids represent a wide class of naturally existing nitrogen‐containing organic compounds having diverse biological activities. They are primary bioactive substances extracted from diverse plant parts. Due to their diverse biological activities, they are frequently used as medicines. The alkaloids have diverse pharmacological impacts on the human body; alkaloids are used for prevention, treatment, and reduction of discomfort associated with chronic illnesses. As most alkaloids exist in plants in complex form, combined with numerous other natural plant components, it is essential to recognize and characterize these molecules using different analytical techniques.ObjectivesWe aimed to review the literature on the methods and protocols for the analysis of naturally occurring alkaloids.MethodsWe carried out a literature survey using the PubMed, Scopus, and Google Scholar databases and other relevant published materials. The keywords used in the searches were “alkaloids,” “analytical methods,” “HPLC method,” “GC method,” “electrochemical methods,” and “bioanalytical methods,” in various combinations.ResultsIn this article, several classes of alkaloids are presented, along with their biological activities. Moreover, it includes a thorough explanation of chromatographic techniques, hyphenated techniques, electrochemical techniques, and current trending analytical methods utilized for the isolation, identification, and comprehensive characterization of alkaloids.ConclusionsThe various analytical techniques play an important role in the identification as well as the characterization of various alkaloids from plants, plasma samples, and urine samples. The hyphenation of various chromatographic techniques with mass spectrometry and NMR spectroscopy plays a crucial role in the characterization of unknown compounds.

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Section: • Indole Alkaloidsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

An insight into recent updates on analytical techniques for bioactive alkaloids

Saini,

Seni,

Chawla

et al. 2024

Phytochemical Analysis

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Bitter yet beneficial: The dual role of dietary alkaloids in managing diabetes and enhancing cognitive function

Alkanad,

Hani,

et al. 2024

BioFactors

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With the rising prevalence of diabetes and its association with cognitive impairment, interest in the use of dietary alkaloids and other natural products has grown significantly. Understanding how these compounds manage diabetic cognitive dysfunction (DCD) is crucial. This comprehensive review explores the etiology of DCD and the effects of alkaloids in foods and dietary supplements that have been investigated as DCD therapies. Data on how dietary alkaloids like berberine, trigonelline, caffeine, capsaicin, 1‐deoxynojirimycin, nuciferine, neferine, aegeline, tetramethylpyrazine, piperine, and others regulate cognition in diabetic disorders were collected from PubMed, Research Gate, Web of Science, Science Direct, and other relevant databases. Dietary alkaloids could improve memory in behavioral models and modulate the mechanisms underlying the cognitive benefits of these compounds, including their effects on glucose metabolism, gut microbiota, vasculopathy, neuroinflammation, and oxidative stress. Evidence suggests that dietary alkaloids hold promise for improving cognition in diabetic patients and could open exciting avenues for future research in diabetes management.

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