All-Optical Modulation of Single Defects in Nanodiamonds: Revealing Rotational and Translational Motions in Cell Traction Force Fields

Wang, Lingzhi; Hou, Yong; Zhang, Tongtong; Wang, Xi; Zhou, Yan; Lei, Dangyuan; Wei, Qiang; Lin, Yuan; Chu, Zhiqin

doi:10.1021/acs.nanolett.2c02232

Cited by 9 publications

(7 citation statements)

References 49 publications

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“…Cells live and function in a highly dynamic environment that varies in ways that significantly influence cellular function ( 67 ). NDs are being investigated as tools to deepen understanding of this microenvironment, including factors such as pH, temperature, and traction ( 27 , 68 ).…”

Section: Diagnostic Applicationsmentioning

confidence: 99%

Nanodiamonds in biomedical research: Therapeutic applications and beyond

Alexander,

Leong

2024

PNAS Nexus

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Nanodiamonds (NDs) comprise a family of carbon-based nanomaterials (i.e., diameter <100 nm) with the same sp3 lattice structure that gives natural diamonds their exceptional hardness and electrical insulating properties. Among all carbon nanomaterials—e.g., carbon nanotubes, nanodots, and fullerenes—NDs are of particular interest for biomedical applications because they offer high biocompatibility, stability in vivo, and a dynamic surface chemistry that can be manipulated to perform a seemingly limitless variety of ultra-specific tasks. NDs are already deepening our understanding of basic biological processes, while numerous laboratories continue studying these novel nanomaterials with an aim of making seismic improvements in the prevention, diagnosis, and treatment of human diseases. This review surveys approximately 2000 the most recent articles published in the last five years and includes references to more than 150 of the most relevant publications on the biomedical applications of NDs. The findings are categorized by contemporary lines of investigation based on potential applications, namely: genetics and gene editing, drug delivery systems, neural interfacing, biomedical sensors, synthetic biology, and organ and tissue regeneration. This review also includes a brief background of NDs and the methods currently developed for their synthesis and preparation. Finally, recommendations for future investigations are offered.

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Section: Diagnostic Applicationsmentioning

confidence: 99%

Nanodiamonds in biomedical research: Therapeutic applications and beyond

Alexander,

Leong

2024

PNAS Nexus

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“…However, despite the huge potential of existing diamond-based PUF labels 38,39,48 , it has not yet been possible to achieve the much-desired high-dimensional (> 2D) encoding. We here propose a method to achieve a 3D encoded diamond-based PUF label, based on the linear polarization modulation (LPM) 47 curves of FNDs with random orientations.…”

Section: Lpm Curves Of Fnds Providing Feasibility For 3d Anticounterf...mentioning

confidence: 99%

“…2c) via Eq. 1 47 with a coe cient of determination usually larger than 0.85. For achieving a sensitive optical readout of the above 3D anticounterfeiting information, a su ciently high LPM contrast value is required.…”

Section: Lpm Curves Of Fnds Providing Feasibility For 3d Anticounterf...mentioning

confidence: 99%

“…Therefore, metric learning is emerging as a promising candidate to solve the existing drawbacks of both the pointby-point comparison and classi cation methods. This paper presents the rst demonstration of high-dimensional (3D) encoding for diamond-based PUF labels, based on our previously reported linear polarization modulation (LPM) of NV centers in uorescent nanodiamonds (FNDs) 47 , as shown in Fig. 1a.…”

Section: Introductionmentioning

confidence: 99%

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High-dimensional anticounterfeiting nanodiamonds authenticated with deep metric learning

Wang

Xin

Zhang

et al. 2023

Preprint

Self Cite

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Physical unclonable function (PUF) labels have emerged as a promising candidate for achieving unbreakable anticounterfeiting. Despite their significant progress, two challenges for developing practical PUF systems remain, namely 1) fairly few high-dimensional encoded labels with excellent material properties, and 2) existing authentication methods with poor noise tolerance or inapplicability to untrained labels. Herein, we employ the linear polarization modulation of randomly distributed fluorescent nanodiamonds (FNDs) to demonstrate, for the first time, three-dimensional encoding for diamond-based labels. Briefly, our 3D encoding scheme provides digitized images with an encoding capacity of 109771 and high distinguishability under a short readout time of 7.5 s. The ultrahigh photostability and inertness of FNDs endow our labels with high reproducibility and long-term stability. To address the second challenge, we employ a deep metric learning algorithm to develop a novel authentication methodology that computes the similarity of deep features of digitized images, exhibiting a superior noise tolerance than the classical point-by-point comparison method. Meanwhile, it overcomes the key limitation of existing artificial intelligence (AI)-driven classification-based methods, i.e., inapplicability to untrained PUF labels. Considering the high performance of both FND PUF labels and deep metric learning authentication, our work paves the way for developing practical PUF anticounterfeiting systems.

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“…Practically, the localized measurement of nanoscale physical quantities such as magnetic fluctuations, electric signals, and temperatures inside or across the membrane has been demonstrated at the early stage. Besides the outstanding spin properties, researchers have also started to harness other optical properties to capture the rotational motions of single NV centers in NDs [ 170 ]. This orientation sensing capability of NV centers can be utilized to detect the membrane force and traction to a subcellular level, which undoubtedly will lead to a new path for a deeper understanding of membrane behaviors and motions.…”

Section: Prospects: Limitations and Opportunitiesmentioning

confidence: 99%

Emerging Diamond Quantum Sensing in Bio-Membranes

Tan

Hou

et al. 2022

Membranes

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Bio-membranes exhibit complex but unique mechanical properties as communicative regulators in various physiological and pathological processes. Exposed to a dynamic micro-environment, bio-membranes can be seen as an intricate and delicate system. The systematical modeling and detection of their local physical properties are often difficult to achieve, both quantitatively and precisely. The recent emerging diamonds hosting quantum defects (i.e., nitrogen-vacancy (NV) center) demonstrate intriguing optical and spin properties, together with their outstanding photostability and biocompatibility, rendering them ideal candidates for biological applications. Notably, the extraordinary spin-based sensing enable the measurements of localized nanoscale physical quantities such as magnetic fields, electrical fields, temperature, and strain. These nanoscale signals can be optically read out precisely by simple optical microscopy systems. Given these exclusive properties, NV-center-based quantum sensors can be widely applied in exploring bio-membrane-related features and the communicative chemical reaction processes. This review mainly focuses on NV-based quantum sensing in bio-membrane fields. The attempts of applying NV-based quantum sensors in bio-membranes to investigate diverse physical and chemical events such as membrane elasticity, phase change, nanoscale bio-physical signals, and free radical formation are fully overviewed. We also discuss the challenges and future directions of this novel technology to be utilized in bio-membranes.

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All-Optical Modulation of Single Defects in Nanodiamonds: Revealing Rotational and Translational Motions in Cell Traction Force Fields

Cited by 9 publications

References 49 publications

Nanodiamonds in biomedical research: Therapeutic applications and beyond

Nanodiamonds in biomedical research: Therapeutic applications and beyond

High-dimensional anticounterfeiting nanodiamonds authenticated with deep metric learning

Emerging Diamond Quantum Sensing in Bio-Membranes

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