All-Solid-State Polyvinyl Chloride Membrane Lithium-Selective Electrode with Improved Selectivity and Its Application in Serum Lithium Assay

Çoldur, Fatih; Andaç, Müberra

doi:10.1166/sl.2011.1717

Cited by 20 publications

(16 citation statements)

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“…Sensitivity is primarily controlled through selection of the chromoionophore and the ratio of the sensor components. Selectivity is controlled through the selection of the lithium ionophore and the addition of TOPO (Trioctylphosphine oxide), which has been shown to increase lithium selectivity in macroscale optodes 20 . We found a similar effect of TOPO on the selectivity of nanosensors (Supporting Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Lithium is a valuable model system for photoacoustic imaging because continuous measurement technologies such as photoacoustics can provide a method to track systemic concentrations of therapeutic drugs and improve disease management. Lithium is a common treatment for bipolar disorder, but it has both a narrow therapeutic window (0.6 – 1.2 mM) and a low toxic dose (~ 2 mM) 20-21 , demonstrating a need for continuous monitoring.…”

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confidence: 99%

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Optical Drug Monitoring: Photoacoustic Imaging of Nanosensors to Monitor Therapeutic Lithium in Vivo

et al. 2015

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Personalized medicine could revolutionize how primary care physicians treat chronic disease and how researchers study fundamental biological questions. To realize this goal we need to develop more robust, modular tools and imaging approaches for in vivo monitoring of analytes. In this report, we demonstrate that synthetic nanosensors can measure physiologic parameters with photoacoustic contrast, and we apply that platform to continuously track lithium levels in vivo. Photoacoustic imaging achieves imaging depths that are unattainable with fluorescence or multiphoton microscopy. We validated the photoacoustic results that illustrate the superior imaging depth and quality of photoacoustic imaging with optical measurements. This powerful combination of techniques will unlock the ability to measure analyte changes in deep tissue and will open up photoacoustic imaging as a diagnostic tool for continuous physiological tracking of a wide range of analytes.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

Optical Drug Monitoring: Photoacoustic Imaging of Nanosensors to Monitor Therapeutic Lithium in Vivo

et al. 2015

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“…An interesting possible alternative to these bulky and complicated methods could be represented by potentiometric all-solid-state ISEs as they enable simplicity of detection, easy miniaturization and low cost. Nonetheless, only a few examples have been proposed in the research community in this direction so far [9], [10], despite the huge impact that those remote monitoring systems could have on patients' quality of life. Carbon nanotubes have been used to fabricate a paper-based Li + ISE by Novell et al in [9].…”

Section: Introductionmentioning

confidence: 99%

“…Carbon nanotubes have been used to fabricate a paper-based Li + ISE by Novell et al in [9]. A small Li + sensor with high selectivity has been described by Coldur et.al in [10]. The system is based on the use of a graphite composite as solid contact.…”

Section: Introductionmentioning

confidence: 99%

A Wearable Electrochemical Sensing System for Non-Invasive Monitoring of Lithium Drug in Bipolar Disorder

et al. 2021

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Lithium represents the main drug for the treatment of Bipolar Disorder (BD) as it acts as a mood stabilizer. However, because of its narrow therapeutic window, psychiatric patients are obliged to frequent tests in hospital to control their lithium blood concentration during therapy. In this paper, we fabricate for the first time a complete noninvasive system for the Therapeutic Drug Monitoring (TDM) of lithium in sweat in people suffering from BD. The wearable electrochemical sensing platform includes a paper fluidics and a stable Reference Electrode (RE). Lithium detection is based on the use of a potentiometric Ion-Selective Electrode (ISE) with a nanostructured solid contact in order to increase the potential stability of the sensor. A chemical chlorination combined with the use of a PVC membrane doped with an Ionic Liquid (IL) is used to minimize possible potential drifts of the RE. The Nernstian response (56.8 ± 3.9 mV /decade) of the system in the range of clinical interest is then proved in aqueous solution and in sweat. The integration of the sensing platform with a paper fluidics transporting fresh sweat sample to the sensing area is also considered. The already tested sweat is collected in a reservoir made of slow adsorbing paper. The complete wearable system is then successfully tested in a simulated setup by using a mannequin. The measured potential is well compared to the predicted ones in the therapeutic window of lithium drug, proving the good sensing capability in artificial sweat.

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“…A paper-based portable ISE with carbon nanotubes as SC has been demonstrated to measure lithium in serum [12]. A miniaturized Li + ISE with improved selectivity has been developed by using a graphite composite for transduction [13]. These devices certainly offer new interesting insights, however some major drawbacks still need to be overcome.…”

Section: Introductionmentioning

confidence: 99%

A novel electrochemical sensor for non-invasive monitoring of lithium levels in mood disorders

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Taurino

Carrara

et al. 2018

2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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Lithium is the main drug for the treatment of mood disorders. Due to its narrow therapeutic window, Therapeutic Drug Monitoring (TDM) is a norm during therapy in order to avoid adverse effects. Consequently, patients are obliged to frequent checkups in hospitals to determine their serum concentration and optimize accordingly the drug dose. Wearable sensors have attracted a growing interest in the research community in recent years owing to their promising impact in personalized healthcare. In particular, sweat diagnosis has seen an enormous expansion and is currently entering the market thanks to the large availability and simple collection of this fluid. In this paper a novel approach for non-invasive decentralized monitoring of lithium drug concentration through sweat analysis is proposed for the first time. An all-solid-state Ion-Selective Electrode (ISE) with a nanostructured Solid-Contact (SC) is used to detect lithium ions in sweat. The sensor offers near-Nernstian behaviour (57.6 ± 2.1 mV/decade) in the concentration range of interest. In addition, it shows fast response (15-30 s), good reversibility and small potential drift over time. A wide pH stability window (pH 4-12) is also proved.

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All-Solid-State Polyvinyl Chloride Membrane Lithium-Selective Electrode with Improved Selectivity and Its Application in Serum Lithium Assay

Cited by 20 publications

References 0 publications

Optical Drug Monitoring: Photoacoustic Imaging of Nanosensors to Monitor Therapeutic Lithium in Vivo

Optical Drug Monitoring: Photoacoustic Imaging of Nanosensors to Monitor Therapeutic Lithium in Vivo

A Wearable Electrochemical Sensing System for Non-Invasive Monitoring of Lithium Drug in Bipolar Disorder

A novel electrochemical sensor for non-invasive monitoring of lithium levels in mood disorders

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