All you need is light

Denis, Tyler G. St.; Dai, Tianhong; Izikson, Leonid; Astrakas, Christos; Anderson, R. Rox; Hamblin, Michael R.; Tegos, George P.

doi:10.4161/viru.2.6.17889

Cited by 219 publications

(86 citation statements)

References 169 publications

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“…In recent years, the synthesis of new compounds for PDI has grown dramatically, many of them with very good inactivation results. Several classes of PS, such as phenothiazinium dyes (methylene blue, toluidine blue O), naturally occurring PS (chlorophylls, psoralens, perylenequinonoid pigments), tetrapyrroles (porphyrins, phthalocyanines, chlorins, bacteriochlorins) and fullerenes have been successfully tested [19][20][21] (Fig. 3).…”

Section: Introductionmentioning

confidence: 99%

Potential applications of porphyrins in photodynamic inactivation beyond the medical scope

Alves

Faustino

Neves

et al. 2015

Journal of Photochemistry and Photobiology C: Photochemistry Re

197

128

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a b s t r a c tAlthough the discovery of light-activated antimicrobial agents had been reported in the 1900s, only more recently research work has been developed toward the use of photodynamic process as an alternative to more conventional methods of inactivation of micro(organisms). The photoprocess causes cell death through irreversible oxidative damage by reactive oxygen species produced by the interaction between a photosensitizing compound and a light source.With great emphasis on the environmental area, photodynamic inactivation (PDI) has been tested in insect eradication and in water disinfection. Lately, other studies have been carried out concerning its possible use in aquaculture waters or to the control of food-borne pathogens. Other potential applications of PDI in household, industrial and hospital settings have been considered.In the last decade, scientific research in this area has gained importance not only due to great developments in the field of materials chemistry but also because of the serious problem of the increasing number of bacterial species resistant to common antibiotics. In fact, the design of antimicrobial surfaces or selfcleaning materials is a very appealing idea from the economic, social and public health standpoints. Thus, PDI of micro(organisms) represents a promising alternative.In this review, the efforts made in the last decade in the investigation of PDI of (micro)organisms with potential applications beyond the medical field will be discussed, focusing on porphyrins, free or immobilized on solid supports, as photosensitizing agents.

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Section: Introductionmentioning

confidence: 99%

Potential applications of porphyrins in photodynamic inactivation beyond the medical scope

Alves

Faustino

Neves

et al. 2015

Journal of Photochemistry and Photobiology C: Photochemistry Re

197

128

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“…aPDT has been successfully applied in vivo and ex vivo tissue or in biological materials for blood sterilization, in animal models of localized infections as surface wounds, burns, oral sites, abscesses, and in the middle ear. aPDT is being clinically studied for several dermatological infections, such as leishmaniosis and mycobacteria [7]. As mentioned before, PDT combines the action of three components: the PS, visible light, and molecular oxygen.…”

Section: Photodynamic Therapy As Antimicrobial Strategy: How It Workmentioning

confidence: 99%

Can Nanotechnology Shine a New Light on Antimicrobial Photodynamic Therapies?

Bloise¹,

Minzioni²,

Imbriani³

et al. 2017

Photomedicine - Advances in Clinical Practice

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Recent developments in light-controlled therapies (e.g., photodynamic and photothermal therapies) provide promising strategies to prevent and suppress bacterial infections, which are a leading cause of morbidity and mortality. Antibacterial photodynamic therapy (aPDT) has drawn increasing attention from the scientific society for its potential to kill multidrug-resistant pathogenic bacteria and for its low tendency to induce drug resistance. In this chapter, we summarize the mechanism of action of aPDT, the photosensitizers, as well the current developments in terms of treating Gram-positive and Gram-negative bacteria. The chapter also describes the recent progress relating to photomedicine for preventing bacterial infections and biofilm formation. We focus on the laser device used in aPDT and on the light-treatment parameters that may have a strong impact on the results of aPDT experiments. In the last part of this chapter, we survey on the various nanoparticles delivering photoactive molecules, and photoactive-nanoparticles that can potentially enhance the antimicrobial action of aPDT.

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“…Clinically, APDT of dental disease is the most commonly employed APDT application in patients due to easy accessibility of the infection site [219]. Tooth decay and periodontitis caused by biofilm infection that encompasses different pathogens warrant the use several different antibiotics [220].…”

Section: In Vivo and Clinical Status Quo Of Antibacterial Photodynamimentioning

confidence: 99%

Antibacterial photodynamic therapy: overview of a promising approach to fight antibiotic-resistant bacterial infections

et al. 2015

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Antibacterial photodynamic therapy (APDT) has drawn increasing attention from the scientific society for its potential to effectively kill multidrug-resistant pathogenic bacteria and for its low tendency to induce drug resistance that bacteria can rapidly develop against traditional antibiotic therapy. The review summarizes the mechanism of action of APDT, the photosensitizers, the barriers to PS localization, the targets, the in vitro-, in vivo-, and clinical evidence, the current developments in terms of treating Gram-positive and Gram-negative bacteria, the limitations, as well as future perspectives. Relevance for patients: A structured overview of all important aspects of APDT is provided in the context of resistant bacterial species. The information presented is relevant and accessible for scientists as well as clinicians, whose joint effort is required to ensure that this technology benefits patients in the post-antibiotic era.

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All you need is light

Cited by 219 publications

References 169 publications

Potential applications of porphyrins in photodynamic inactivation beyond the medical scope

Potential applications of porphyrins in photodynamic inactivation beyond the medical scope

Can Nanotechnology Shine a New Light on Antimicrobial Photodynamic Therapies?

Antibacterial photodynamic therapy: overview of a promising approach to fight antibiotic-resistant bacterial infections

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