Allatoregulatory peptides in Lepidoptera, structures, distribution and functions

Audsley, Neil; Matthews, H. June; Price, Nicholas R.; Weaver, Robert J.

doi:10.1016/j.jinsphys.2008.01.012

Cited by 63 publications

(27 citation statements)

References 61 publications

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“…(1) Brown et al, 1999; (2) Rohwedder et al, 2015; (3) Mercer et al, 2011; (4) Schoofs et al, 1993; (5) Siviter et al, 2000; (6) Nässel et al, 1998; (7) Holzer and Holzer-Petsche, 1997; (8) Hökfelt et al, 2001; (9) Coast et al, 2001; (10) Johnson et al, 2005; (11) Brugge et al, 2008; (12) LaJeunesse et al, 2010; (13) Vanderveken and O'Donnell, 2014; (14) Sternini, 1991; (15) Kendig et al, 2014; (16) Rattan and Tamura, 1998; (17) Anselmi et al, 2005; (18) Kaminski et al, 2002; (19) Veenstra, 2009; (20) Corleto, 2010; (21) Farhan et al, 2013; (22) Veenstra and Ida, 2014; (23) Ren et al, 2015; (24) Sano et al, 2015; (25) Takizawa et al, 2005; (26) Sterkel et al, 2012; (27) Chen et al, 2015; (28) Carlsson et al, 2013; (29) Slade and Staveley, 2016; (30) Bhatt and Horodyski, 1999; (31) Duve et al, 2000; (32) Rankin et al, 2005; (33) Audsley et al, 2008; (34) Heinonen et al, 2008; (35) Duve et al, 1994; (36) Audsley and Weaver, 2009; (37) Dockray, 2009.…”

Section: Figurementioning

confidence: 99%

bHLH proneural genes as cell fate determinants of entero-endocrine cells, an evolutionarily conserved lineage sharing a common root with sensory neurons

Hartenstein

Takashima

Hartenstein

et al. 2017

Developmental Biology

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Entero-endocrine cells involved in the regulation of digestive function form a large and diverse cell population within the intestinal epithelium of all animals. Together with absorptive enterocytes and secretory gland cells, entero-endocrine cells are generated by the embryonic endoderm and, in the mature animal, from a pool of endoderm derived, self-renewing stem cells. Entero-endocrine cells share many structural/functional and developmental properties with sensory neurons, which hints at the possibility of an ancient evolutionary relationship between these two cell types. We will survey in this article recent findings that emphasize the similarities between entero-endocrine cells and sensory neurons in vertebrates and insects, for which a substantial volume of data pertaining to the entero-endocrine system has been compiled. We will then report new findings that shed light on the specification and morphogenesis of entero-endocrine cells in Drosophila. In this system, presumptive intestinal stem cells (pISCs), generated during early metamorphosis, undergo several rounds of mitosis that produce the endocrine cells and stem cells (ISCs) with which the fly is born. Clonal analysis demonstrated that individual pISCs can give rise to endocrine cells expressing different types of peptides. Immature endocrine cells start out as unpolarized cells located basally of the gut epithelium; they each extend an apical process into the epithelium which establishes a junctional complex and apical membrane specializations contacting the lumen of the gut. Finally, we show that the Drosophila homolog of ngn3, a bHLH gene that defines the entero-endocrine lineage in mammals, is expressed and required for the differentiation of this cell type in the fly gut.

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Section: Figurementioning

confidence: 99%

bHLH proneural genes as cell fate determinants of entero-endocrine cells, an evolutionarily conserved lineage sharing a common root with sensory neurons

Hartenstein

Takashima

Hartenstein

et al. 2017

Developmental Biology

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“…They also play a role during oogenesis, vitellogenesis and muscle contraction in midgut, either directly or indirectly via inhibiting JH123. It has been shown that oral administration of Allatostatin (AST) or its analogs reduce survival and nymph production in pea aphids4.…”

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confidence: 99%

Ligand binding pocket of a novel Allatostatin receptor type C of stick insect, Carausius morosus

Sahbaz

Sezerman

Torun

et al. 2017

Sci Rep

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Allatostatins (AST) are neuropeptides with variable function ranging from regulation of developmental processes to the feeding behavior in insects. They exert their effects by binding to cognate GPCRs, called Allatostatin receptors (AlstR), which emerge as promising targets for pesticide design. However, AlstRs are rarely studied. This study is the first reported structural study on AlstR-AST interaction. In this work, the first C type AlstR from the stick insect Carausius morosus (CamAlstR-C) was identified and its interaction with type C AST peptide was shown to be physically consistent with the experimental results. The proposed structure of CamAlstR-C revealed a conserved motif within the third extracellular loop, which, together with the N-terminus is essential for ligand binding. In this work, computational studies were combined with molecular and nano-scale approaches in order to introduce an unknown GPCR-ligand system. Consequently, the data obtained provided a reliable target region for future agonist/inverse agonist studies on AlstRs.

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“…Our real-time PCR data show that the Tc-AT mRNAs are expressed in an isoform-specific and time-and tissue-specific manner. Preprohormones of AS Clike peptides have been cloned from various lepidopteran and dipteran species [7]. The present expression analyses reveal that the Tc-AS C is expressed as a brain-gut peptide in a developmentalspecific manner.…”

Section: Discussionmentioning

confidence: 71%

Functional activity of allatotropin and allatostatin in the pupal stage of a holometablous insect, Tribolium castaneum (Coleoptera, Tenebrionidae)

Abdel-latief

Hoffmann

2014

Peptides

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Allatoregulatory peptides in Lepidoptera, structures, distribution and functions

Cited by 63 publications

References 61 publications

bHLH proneural genes as cell fate determinants of entero-endocrine cells, an evolutionarily conserved lineage sharing a common root with sensory neurons

bHLH proneural genes as cell fate determinants of entero-endocrine cells, an evolutionarily conserved lineage sharing a common root with sensory neurons

Ligand binding pocket of a novel Allatostatin receptor type C of stick insect, Carausius morosus

Functional activity of allatotropin and allatostatin in the pupal stage of a holometablous insect, Tribolium castaneum (Coleoptera, Tenebrionidae)

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