Allele, genotype, and composite genotype effects of IL-1A +4845 and IL-1B +3954 polymorphisms for chronic periodontitis in an Indian population

Gayathri, R; Saadi, Abdul Vahab; Bhat, Kumar M.R.; Bhat, Somashekara; Satyamoorthy, Kapaettu

doi:10.4103/0970-9290.90323

Cited by 15 publications

(8 citation statements)

References 39 publications

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“…However, contradictory results were obtained in a recently published data 28 where they have found that for IL-1β +3954 CC genotype was the more frequently genotype identified in cases than in controls.…”

Section: Resultsmentioning

confidence: 81%

Cytokine Gene Polymorphisms Associate with Microbiogical Agents in Periodontal Disease: Our Experience

Cantore¹,

Mirgaldi²,

Ballini³

et al. 2014

Int. J. Med. Sci.

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Periodontics has evolved from a simplistic model to a more complex interplay between infection and host response. Genetic factors have been a new addition to the list of risk factors for periodontal diseases. The processes leading to destruction and regeneration of the destroyed tissues are of great interest to both researchers and clinicians.The selective susceptibility of subjects for periodontitis has remained an enigma and wide varieties of risk factors have been implicated for the manifestation and progression of periodontitis. Emerging pathway models suggest that gene-environment interactions are etiologically important in disease pathogenesis. The current practical utility of genetic knowledge in periodontitis is limited.Allelic variants at multiple gene loci probably influence periodontitis susceptibility. The pro-inflammatory cytokine interleukin-1 (IL-1) is a key modulator of host responses to microbial infection and a major modulator of extracellular matrix catabolism and bone resorption, and polymorphisms in the IL-1 gene cluster have been associated with an increased risk of developing severe adult periodontitis.The aim of this study was to test if polymorphisms of genes of IL-1α+4845 and IL-1β +3954 were linked with periodontitis, in a case-control study population, delimited to a specific geographic area, in association with microbiological findings.The polymorphisms observed in IL-1α+4845 and IL-1β+3954 single nucleotide polymorphisms (SNPs), was significantly different among the study groups (healthy controls, mild, moderate and severe periodontitis with p<0.05, d.f.=1.We found a significant correlation between the severe form of periodontitis and the presence of composite genotype (p < 0.05, d.f.=1, calculated among healthy vs. severe). Furthermore a statistically significant association between the presence of bacteria and periodontitis was detected (p<0.05, d.f.=1). In the current investigation findings were concordant with literature observations.

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Section: Resultsmentioning

confidence: 81%

Cytokine Gene Polymorphisms Associate with Microbiogical Agents in Periodontal Disease: Our Experience

Cantore¹,

Mirgaldi²,

Ballini³

et al. 2014

Int. J. Med. Sci.

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“…The studies used various genotyping methods, including polymerase chain reaction-restriction fragment length polymorphism, polymerase chain reaction with sequence-specific primers and TaqMan analysis. Five studies were not in agreement with the Hardy-Weinberg equilibrium of the genotype distribution in the controls [ 11 , 12 , 20 , 32 , 36 ]. Seven studies enrolled Indian subjects [ 25 , 27 , 30 – 32 , 35 , 36 ], and eight enrolled Chinese subjects [ 11 , 12 , 19 , 20 , 22 , 24 , 26 , 27 ].…”

Section: Resultsmentioning

confidence: 99%

Systematic review/Meta-analysis Interleukin-1β (3953/4) C→T polymorphism increases the risk of chronic periodontitis in Asians: evidence from a meta-analysis of 20 case-control studies

Ma¹,

Chu²,

Zhu³

et al. 2015

aoms

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IntroductionTo investigate the association of the interleukin-1β (IL-1β) (3953/4) C→T polymorphism with chronic periodontitis (CP) in Asians.Material and methodsSystematic searches of electronic databases and hand searching of references were performed, including PubMed, Embase, the Cochrane Library, and the Chinese National Knowledge Infrastructure (CNKI). Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the associations. Publication bias was tested by Egger's test. Sensitivity analysis was conducted by limiting the meta-analysis studies conforming to Hardy-Weinberg equilibrium (HWE). Data analyses were carried out using RevMan 6.0.ResultsA meta-analysis was performed on 20 published case-control studies, including 1,656 CP cases and 1,498 healthy controls. The pooled OR was 1.60 (95% CI = 1.02–2.52, p = 0.04) for the T allele carriers (TT + CT) compared with CC and 1.60 (95% CI = 1.06–2.42, p = 0.02) for T vs. C. Subgroup analysis by country revealed significant risks of CP among Indians carrying the T allele (TT vs. CC: OR = 3.88, 95% CI = 1.77–8.50, p = 0.0007).ConclusionsThe analysis showed that IL-1β (3953/4) C→T polymorphism probably increases the risk of CP in Asians, and the IL-1β+3954 TT genotype may be associated with a strongly increased risk of CP in Indians, but not in Chinese.

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“…In cultured human umbilical vein endothelial cells, IL1β activated VCAM-1 gene expression ( 29 ). Several previous studies have demonstrated strong associations between the high frequency of genetic polymorphism in IL1β and the development of severe chronic periodontitis ( 30 – 32 ). Gursoy et al ( 33 )revealed that IL1β was the only biomarker associated with periodontitis among the salivary cytokines and enzymes tested.…”

Section: Discussionmentioning

confidence: 97%

Identification of several hub-genes associated with periodontitis using integrated microarray analysis

Guo

Wang

Chen

2014

Molecular Medicine Reports

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The aim of the present study was to identify differentially expressed genes and biological processes associated with periodontitis. In this study, the most significant 200 differentially expressed genes associated with periodontitis were identified using integrated analysis of multiple microarray data in combination with screening for genome-wide relative significance and genome-wide global significance. Gene Ontology (GO) enrichment analysis and pathway analysis were performed using the GO website and Kyoto Encyclopedia of Genes and Genomes (KEGG). A protein-protein interaction (PPI) network was constructed based on the Search Tool for the Retrieval of Interacting Genes/Proteins. The top 200 differentially expressed genes were found to be highly associated with periodontitis. GO enrichment analyses revealed that the identified genes were significantly enriched in terms of response to organic substance, response to wounding and cell migration. The most common term of the KEGG pathway was cytokine-cytokine receptor interaction. PPI network analysis indicated that interleukin (IL)8, IL1β, vascular endothelial growth factor A, intercellular adhesion molecule 1, PTGS2 and CXCL10 were hub genes, which formed numerous interactions with several genes. In conclusion, the present study identified numerous genes that were differentially expressed in periodontitis, as well as determined the biological pathways and PPI network associated with those genes.

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Allele, genotype, and composite genotype effects of IL-1A +4845 and IL-1B +3954 polymorphisms for chronic periodontitis in an Indian population

Cited by 15 publications

References 39 publications

Cytokine Gene Polymorphisms Associate with Microbiogical Agents in Periodontal Disease: Our Experience

Cytokine Gene Polymorphisms Associate with Microbiogical Agents in Periodontal Disease: Our Experience

Systematic review/Meta-analysis Interleukin-1β (3953/4) C→T polymorphism increases the risk of chronic periodontitis in Asians: evidence from a meta-analysis of 20 case-control studies

Identification of several hub-genes associated with periodontitis using integrated microarray analysis

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