Allelic Variants for Complement Factors C3, C4, and B in Acute Necrotizing Ulcerative Gingivitis

Melnick, Sandra; Go, Rodney C.P.; Cogen, Ronald B.; Roseman, Jeffrey M.

doi:10.1177/00220345880670051101

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…Negative results from studies of possible association between known inherited disorders and periodontal disease should not be discounted as of no relevance since they can help to narrow the focus of interest to host factors of greater importance. In this connection, recent reports have provided no evidence for an association of IgA deficiency or agammaglobulinaemia with periodontitis (Robertson et al 1980) or of inherited variants of complement components C3, C4 and B with acute necrotising ulcerative gingivitis (Melnick et al 1988). The relationship between periodontitis and diabetes mellitus is controversial (Hugoson et al 1989).…”

Section: Perjodontal Disease As Part Of Inherited Disordersmentioning

confidence: 97%

Genetic approaches in the study of periodontal diseases

Sofaer

1992

J Clin Pharm Ther

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Section: Perjodontal Disease As Part Of Inherited Disordersmentioning

confidence: 97%

Genetic approaches in the study of periodontal diseases

Sofaer

1992

J Clin Pharm Ther

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“…Local factors (see Appendix 4, Table A4.5d, in online journal), including decorative crowns or orthodontic therapy may favor the onset of NG. Body geometry, thermoregulatory abnormalities, allelic variants for complement factors, and properdin factor B or erythrocyte catalase activity, have also been studied with inconclusive results.…”

Section: Necrotizing Periodontal Diseasesmentioning

confidence: 99%

Acute periodontal lesions (periodontal abscesses and necrotizing periodontal diseases) and endo‐periodontal lesions

Herrera

Retamal‐Valdes

Alonso

et al. 2018

J Clinic Periodontology

106

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Objective To critically evaluate the existing literature on acute lesions occurring in the periodontium (periodontal abscesses [PA], necrotizing periodontal diseases [NPD], and endo‐periodontal lesions [EPL]) to determine the weight of evidence for the existence of specific clinical conditions that may be grouped together according to common features. The ultimate goal is to support an objective classification system. Importance Although PA, NPD, and EPL occur with relatively low frequency, these lesions are of clinical relevance, because they require immediate management and might severely compromise the prognosis of the tooth. Findings In general, the evidence available to define these three conditions was considered limited. PA and EPL are normally associated with deep periodontal pockets, bleeding on probing, suppuration, and almost invariably, with pain. EPL are also associated with endodontic pathology. NPDs have three typical features: pain, bleeding, and ulceration of the gingival interdental papilla. The available data suggested that the prognosis of PA and EPL are worse in periodontitis than in nonperiodontitis patients. Lesions associated with root damage, such as fractures and perforations, had the worst prognosis. NPD progression, extent and severity mainly depended on host‐related factors predisposing to these diseases. Conclusions PA should be classified according to the etiological factors involved, with the most frequent being those occurring in pre‐existing periodontal pockets. NPD are clearly associated with the host immune response, which should be considered in the classification system for these lesions. EPLs should be classified according to signs and symptoms that have direct impact on their prognosis and treatment, such as presence or absence of fractures and perforations, and presence or absence of periodontitis.

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“…However, evidence is inconclusive in this event, and additional research is still required before making conclusions. [46][47][48][49]…”

Section: Discussionmentioning

confidence: 99%

Etiology and types of necrotizing periodontal diseases

Abdullah

Albeshr

Albasher

et al. 2021

Int J Community Med Public Health

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Necrotizing periodontal diseases pose a clinical significance because it has been associated with a severe prognosis that can cumulatively lead to rapid tissue destruction. A slow rate of destruction has been reported for patients with necrotizing periodontal diseases, and reports show that chronicity might be a characteristic in some patients, while many patients might also suffer from disease recurrence. The association of other oral lesions might also be a characteristic in some situations, which usually occurs in cases when systemic involvement is present. In the present literature review, we aim to discuss the etiology and types of necrotizing periodontal diseases based on evidence from the different related studies in the literature. Microbiology plays an important role in the pathogenesis of the condition, and some organisms as spirochetes were directly correlated with the etiology of the condition. Evidence also shows that the presence of the different risk factors might be the major contributor to the development of the condition as different risk factors were found to be directly correlated with the disease. Among the different factors, impacted host immune response and the presence of deteriorating systemic conditions have been widely reported in the literature as significant factors predisposing to developing the disease. Other factors as smoking and alcohol consumption, previous history of the disease, and other oral lesions, were also reported. Further research is needed for better classification of the condition and determination of more significant risk factors.

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Allelic Variants for Complement Factors C3, C4, and B in Acute Necrotizing Ulcerative Gingivitis

Cited by 5 publications

References 24 publications

Genetic approaches in the study of periodontal diseases

Genetic approaches in the study of periodontal diseases

Acute periodontal lesions (periodontal abscesses and necrotizing periodontal diseases) and endo‐periodontal lesions

Etiology and types of necrotizing periodontal diseases

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