Allelic variations in the CYBA gene of NADPH oxidase and risk of kidney complications in patients with type 1 diabetes

Plasma concentrations of 8-hydroxy-2′-deoxyguanosine and risk of kidney disease and death in individuals with type 1 diabetes

“…Earlier studies have suggested involvement of AOPP in the pathophysiology of diabetic kidney disease [34,35]. We previously reported the association of plasma AOPP with diabetic nephropathy stages at baseline and the risk of ESRD during follow-up in the GENEDIAB cohort [11,36]. In the present analyses of GENEDIAB and GENESIS pooled cohorts, the association of either 8-OHdG or AOPP with ESRD appeared to be independent, with no evidence for interaction.…”

“…Chronic hyperglycaemia activates numerous biochemical pathways through mitochondrial overproduction of reactive oxygen species (ROS) [5]. Increased ROS production with decreased antioxidant capacity leads to oxidative stress, which plays an important role in the pathogenesis of kidney disease in individuals with diabetes [6][7][8][9][10][11]. Oxidative stress affects lipids, proteins and DNA and leads to changes in cell structure and function [12,13].…”

Plasma Copeptin, Kidney Outcomes, Ischemic Heart Disease, and All-Cause Mortality in People With Long-standing Type 1 Diabetes

“…We considered the incidence of three outcomes during follow-up: ESRD, a coronary event (defined as the occurrence of myocardial infarction and/or coronary revascularization procedure), and all-cause mortality. Characteristics of GENEDIAB and GENESIS participants at baseline by the incidence of ESRD and all-cause mortality during follow-up were published previously (22,23). Incidence rates and clinical data reported in the present study are those of the subsets of participants with an available plasma sample at baseline for copeptin assay.…”

Importance of intensive blood pressure control in type 2 diabetes: Mechanisms, treatments and current guidelines

“…The activity of several enzymes associated with oxido‐reduction balance can modulate albuminuria in experimental conditions . The gene variants in some of these enzymes were independent predictors of renal and CV outcomes of patients with diabetes during propective follow‐up studies …”