Background: Orobanche crenata (Broomrape) is an obligate root parasitic weed belonging to Orobanchaceae. It causes a great damage to legume crops. Many attempts have been done in order to control this parasitic weed. So, the aim of this work is to study the allelopathic potentiality of Eruca sativa seed powder (Essp) in comparison to the herbicidal effect of Basamid (Dazomet) treatments in controlling Orobanche crenata (O. crenata) and their effect on growth and yield of two Vicia faba cultivars. Materials/methods: Two pot experiments were conducted in the greenhouse of the National Research Centre, Dokki, Giza, Egypt, in the two successive winter seasons of 2015/2016 and 2016/2017. Treatments were applied by incorporating Essp to the soil at (15, 30, and 45 g/kg soil) and Basamid treatments at 0.2 and 0.4 g/pot. Results: All Essp concentrations used as well as Basamid treatments minimized to great extent, the number of O. crenata tubercles/pot, and the fresh and the dry weight of O. crenata tubercles/pot (g) infecting both V. faba cultivars at 90 days after sowing (DAS) and at harvest. The best results for controlling O. crenata infesting both V. faba cultivars were recorded with both 45 g/kg soil Essp concentration and 0.4 g/pot Basamid treatments. On the other side, both V. faba cultivars growth as well as yield and yield attributes were significantly increased with all Essp concentrations used and Basamid treatments when compared to their corresponding infected control. Essp at 45 g/kg soil and 0.4 g/pot Basamid treatments gave the highest increases which exceed than their corresponding healthy control. Conclusion: The presence of the allelochemicals mainly glucosinolates and phenolic compounds in Essp could play an important role, as a natural selective bioherbicide, in controlling the parasitic O. crenata weed infecting V. faba cultivars and increasing the yield.