Allergen immunotherapy using recombinant Culicoides allergens improves clinical signs of equine insect bite hypersensitivity
Anneli Graner,
Ralf S. Mueller,
Johanna Geisler
et al.
Abstract:IntroductionInsect bite hypersensitivity (IBH) is an IgE-mediated allergic dermatitis of horses caused by bites of Culicoides spp., sharing some common features with human atopic dermatitis. Allergen immunotherapy (AIT) using Culicoides whole-body extracts has limited efficacy. This study aimed to evaluate AIT with a pool of major Culicoides recombinant allergens in a prospective, double-blinded, placebo-controlled study.MethodsThe IBH lesion score was assessed during a pre-treatment year and first treatment y… Show more
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