Allergen-Specific IL-5 Responses in Early Childhood Predict Asthma at Age Eight

Weber‐Chrysochoou, Christina; Crisafulli, Daniel; Kemp, Andrew; Britton, Warwick J.; Marks, Guy B.

doi:10.1371/journal.pone.0097995

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…However, it should also be noted that no significant difference was observed in HDM-specific IL-5 responses between the two groups after adjusting for allergy status. Our results indicate that HDMinduced IL-5 production can be considered as a predictor for the presence of atopy in children with asthma, as has been suggested by others (27). Additional questions of concern relate to the effects that corticosteroids may have on the observed differences in immune responses of PBMCs.…”

Section: Discussionsupporting

confidence: 78%

Children With Asthma Have Impaired Innate Immunity and Increased Numbers of Type 2 Innate Lymphoid Cells Compared With Healthy Controls

et al. 2021

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BackgroundAsthma is the most frequent cause of hospitalisation among children; however, little is known regarding the effects of asthma on immune responses in children.ObjectiveThe present study aimed to evaluate cytokine responses of peripheral blood mononuclear cells (PBMCs), PBMC composition and lung function in children with and without asthma.MethodsUsing a case-control design, we compared 48 children with asthma aged 3-11 years with 14 age-matched healthy controls. PBMC composition and cytokine production including interferon (IFN)-γ, interleukin (IL)-1β, IL-5 and lL-6 following stimulation with rhinovirus-1B (RV1B), house dust mite (HDM) and lipopolysaccharide (LPS) were measured. Lung function was assessed using impulse oscillometry and nitrogen multiple breath washout.ResultsThe frequency of group 2 innate lymphoid cells were significantly higher in asthmatics and PBMCs from asthmatics had deficient IFN-γ production in response to both RV1B and LPS compared with controls (P<0.01). RV1B-induced IL-1β response and HDM-stimulated IL-5 production was higher in asthmatics than controls (P<0.05). In contrast, IL-1β and IL-6 were significantly reduced in response to HDM and LPS in asthmatics compared to controls (P<0.05). Children with asthma also had reduced pulmonary function, indicated by lower respiratory reactance as well as higher area of-reactance and lung clearance index values compared with controls (P<0.05).ConclusionOur study indicates that children with asthma have a reduced lung function in concert with impaired immune responses and altered immune cell subsets. Improving our understanding of immune responses to viral and bacterial infection in childhood asthma can help to tailor management of the disease.

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Section: Discussionsupporting

confidence: 78%

Children With Asthma Have Impaired Innate Immunity and Increased Numbers of Type 2 Innate Lymphoid Cells Compared With Healthy Controls

et al. 2021

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“…Also, this study showed no significant differences (P=0.585) or (P=0.727) between mild and moderate asthmatic patients regarding aggravation by dogs and birds, respectively. This study was incompatible with a survey conducted by (Weber-Chrysochoou et al, 2014), who confirmed that birds may exacerbate asthma severity. This variety may be attributable to the difference in sample group or differences in study geographic location and also socio-cultural variations of study subjects.…”

Section: Discussioncontrasting

confidence: 67%

Association Between Serum Level of Interleukin-15 and Severity of Pediatric Asthma

AL-Hasnawi,

Ali,

Al-Saadi

et al. 2024

Journal-Pharmacy

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Background: A chronic inflammatory process of the airways is a common characteristic of asthma, representing a primary health problem. This disease can infect people of all ages, about 3.5-20 % of the population, but it usually begins in childhood. Objective: To evaluate the relationship between interleukin-15 and pediatric asthma severity. Methods: The current study is a case-control study that includes 60 asthmatic participants as the patient group and 60 non-asthmatic participants as the control group. Sandwich ELISA using an ELISA kit can be used for the measurement of IL-15 and IgE serum levels. Results: Elevated serum level of IgE in the patients group compared with a control group with significant (P= 0.005) was a result of this study, and there were no significant differences between patients and control about IL- 15 serum levels with (P= 0.968) in asthmatic children. Conclusions: According to the present study, there was a non-significant association between the severity of asthma and the serum level of IL-15 in children.

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“…Thus, miR-146a might regulate the expression of vascular cell adhesion molecule-1, and the reduced IgE level might correlate with the expression of IL-4. In addition, IL-5 induces the development, recruitment and activation of eosinophils to the lung [34]. Activated eosinophils generate extensive chemokines and cytokines and are a predominant source of platelet-activating factor and lipid mediator leukotriene C4, inducing smooth muscle contraction and mucus secretion [35].…”

Section: Discussionmentioning

confidence: 99%

miR-146a Mimics Attenuate Allergic Airway Inflammation by Impacted Group 2 Innate Lymphoid Cells in an Ovalbumin-Induced Asthma Mouse Model

Han¹,

Ma²,

Bao³

et al. 2018

Int Arch Allergy Immunol

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Background: The prevalence of allergic asthma has increased dramatically. Previous studies have found that the microRNA 146a (miR-146a) expression in asthma inhibits cell proliferation and promotes apoptosis of bronchial smooth muscle cells. We aimed to investigate the effect of miR-146a mimics on ovalbumin (OVA)-induced asthma in a mouse model. Methods: Inflammatory cell infiltration in bronchoalveolar lavage fluid (BALF) was measured by flow cytometry. Levels of OVA-specific immunoglobulin E (IgE) in serum and cytokines in BALF were examined by enzyme-linked immunosorbent assay. For monitoring the airway, the Penh value (% baseline) was measured using a whole-body plethysmograph. Results: In OVA-induced asthmatic mice, miR-146a significantly suppressed the infiltration of inflammatory cells in BALF and decreased the levels of OVA-specific IgE and T helper 2 cell type cytokines. In addition, miR-146a inhibited the OVA-induced airway hyperresponsiveness and the group 2 innate lymphoid cell responses. Moreover, the effects of miR-146a mimics were dependent on interleukin 33 stimulation. Conclusions: Our results suggest that miR-146a mimics might serve as an attractive candidate for further preclinical studies as an anti-inflammatory treatment of asthma.

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Allergen-Specific IL-5 Responses in Early Childhood Predict Asthma at Age Eight

Cited by 6 publications

References 25 publications

Children With Asthma Have Impaired Innate Immunity and Increased Numbers of Type 2 Innate Lymphoid Cells Compared With Healthy Controls

Children With Asthma Have Impaired Innate Immunity and Increased Numbers of Type 2 Innate Lymphoid Cells Compared With Healthy Controls

Association Between Serum Level of Interleukin-15 and Severity of Pediatric Asthma

miR-146a Mimics Attenuate Allergic Airway Inflammation by Impacted Group 2 Innate Lymphoid Cells in an Ovalbumin-Induced Asthma Mouse Model

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