Allergenic cross‐reactivity in the Liliaceae family

Sánchez‐Hernández, M. C.; Hernández, María del Mar Benítez; Delgado, J.; Guardia, P.; Monteseirı́n, Javier; Bartolomé, B; Palácios, Ricardo; Martínez, Javier Jesús González; Condé, J.

doi:10.1034/j.1398-9995.2000.00460.x

Cited by 22 publications

(16 citation statements)

References 5 publications

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“…Sanchez-Hernandez and colleagues evaluated the possible allergic cross-reactivity in this botanical family. Two patients with an established diagnosis of IgE-mediated contact urticaria caused by cooked white asparagus (as demonstrated by rub test, prick test, and specific IgE test) showed a positive result in the prick-prick test with native onion and garlic [35].…”

Section: Allergic Reactionsmentioning

confidence: 99%

“…Clinical studies have shown that garlic may cause mild gastrointestinal complaints following administration of therapeutic doses of garlic [35,27,82]. During the course of the observational study, the side effects occurring in a total of 1997 patients on treatment with 900 mg daily garlic powder per coated tablets (three tablets/day) included gastrointestinal complaints (incidence of adverse effects: 6% nausea, less than 0.8% bloating) [27].…”

Section: Gastrointestinal Adverse Effectsmentioning

confidence: 99%

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Garlic (Allium sativum L.): Adverse effects and drug interactions in humans

Borrelli

Capasso

Izzo³

2007

Molecular Nutrition Food Res

204

120

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Garlic (Alllium sativum L., Fam Liliaceae) is used medicinally mainly for the treatment of hypercholesterolemia and prevention of arteriosclerosis. Clinical trials have consistently shown that "garlic breath" and body odor are the most common (and well-documented) complaints associated to garlic intake. Case reports have highlighted the possibility that garlic use may cause allergic reactions (allergic contact dermatitis, generalized urticaria, angiedema, pemphigus, anaphylaxis and photoallergy), alteration of platelet function and coagulation (with a possible risk of bleeding), and burns (when fresh garlic is applied on the skin, particularly under occlusive dressings). Consumption of garlic by nursing mothers modifies their infant's behavior during breast-feeding. Finally, garlic may enhance the pharmacological effect of anticoagulants (e. g. warfarin, fluindione) and reduce the efficacy of anti-AIDS drugs (i. e. saquinavir).

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Section: Allergic Reactionsmentioning

confidence: 99%

Section: Gastrointestinal Adverse Effectsmentioning

confidence: 99%

Garlic (Allium sativum L.): Adverse effects and drug interactions in humans

Borrelli

Capasso

Izzo³

2007

Molecular Nutrition Food Res

204

120

View full text Add to dashboard Cite

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“…21 However in another study asparagus was shown to significantly inhibit onion RAST reactivity whereas asparagus RAST was partially inhibited by onion. 6 The observed discrepancy was explained by the presence of a smaller amount of common allergenic content in onion compared to asparagus. It would be however interesting to further investigate the cross reactivity of Liliaceae family by correlating the presence of the allergen specific IgE antibodies in blood with skin reactivity.…”

Section: Discussionmentioning

confidence: 96%

“…Allergenic cross-reactivity has been detected not only among the members of Liliaceae family 6 but also between the members of this family and grass pollens. 7 The Lilaiceae vegetables have been shown to be capable of inducing contact sensitization 8,9 to an extent that in some countries garlic is being considered next to nickel as an allergen inducing allergic contact dermatitis.…”

Section: Introductionmentioning

confidence: 99%

Garlic and onion sensitization among Saudi patients screened for food allergy: A hospital based study

Almogren¹,

Shakoor²,

Adam³

2013

Afr H. Sci.

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Background: Detection of specific IgE antibodies against food materials indicates allergic sensitization. Some very widely consumed foods materials such as garlic and onion have rarely been investigated for their allergenic potential. Objectives: To assess the presence of garlic and onion specific IgE antibodies in patients investigated for food allergy. Methods: Radioallergosorbent test (RAST) results of 108 patients with clinical suspicion of food allergy who were specifically screened for garlic and onion specific IgE antibodies along with other food allergens were analyzed retrospectively at King Khalid University Hosptial between January 2008 and April 2009. This group of patients included 73 males and 35 females with mean age 27+13.2 years. Estimation of garlic and onion specific IgE antibodies was performed by radioallergosorbent test (RAST) using Pharmacia ImmunoCAP 250 analyzer. Results: Out of the 108 patients 15 (13.8%) had garlic and onion specific IgE antibodies in their sera. Garlic specific IgE antibodies with the RAST scores between one to four were present in 14 and onion specific IgE were detected in 13 patients. For garlic specific IgEs majority of patients (08) had RAST score of one (0.35-0.69 kU/L) and for onion specific IgE antibodies seven patients had RAST score of two (0.70-3.49 kU/L). Among these patients 12 (80%) were found to have coexisting specific IgE antibodies against garlic and onion. Conclusion: The presence of garlic and onion specific IgE antibodies in a sizeable number of patients indicate sensitization and allergenic potential of these food materials.

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“…In der Literatur finden sich Fälle von Kreuzallergien der Liliengewächse untereinander, jedoch konnten bei unserem Patienten keine Kreuzallergien nachgewiesen werden [7]. Nahrungsmittelallergien sind häufig mit einem Atopiesyndrom assoziiert [2,8].…”

Section: Kommentarunclassified

Typ-I- und Typ-IV-Sensibilisierung auf Asparagus officinalis

et al. 2004

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Asparagus (Asparagus officinalis),a member of the Liliaceae family, is a popular vegetable, most commonly eaten in May. A 55-year-old cook presented with seasonal (always in May) recurrent dyshidrosiform hand eczema which prevented him from working. He also reported developing dyspnea and dysphagia after consuming asparagus. Diagnostic allergy testing revealed positive reactions against asparagus in prick-to-prick and epicutaneous patch tests.

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Allergenic cross‐reactivity in the Liliaceae family

Cited by 22 publications

References 5 publications

Garlic (Allium sativum L.): Adverse effects and drug interactions in humans

Garlic (Allium sativum L.): Adverse effects and drug interactions in humans

Garlic and onion sensitization among Saudi patients screened for food allergy: A hospital based study

Typ-I- und Typ-IV-Sensibilisierung auf Asparagus officinalis

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