Allergic and nonallergic rhinitis

Agnihotri, Neha; McGrath, Kris G.

doi:10.2500/aap.2019.40.4251

Cited by 53 publications

(30 citation statements)

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“…Nasal polyps defined as blue gray protuberance masses in the nasal cavity, characterized by eosinophil inflammation, and accompanied by acetylsalicylic intolerance in up to 25% of cases [1] . Forty percent of cases of nasal polyposis are associated with intrinsic asthma, linked to aspirin sensitivity or may represent part of a systemic disease such as cystic fibrosis [2] .…”

Section: Introductionmentioning

confidence: 99%

Incidence of Nasal Polyps Recurrence Rate in Patients with Eosinophilic Oesophagitis after Endoscopic Endonasal Surgery.

Sarhan

Fathallah

Wahba

et al. 2020

International Journal of Medical Arts

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Background: Nasal polys [NPs] are frequently encountered in otorhinolaryngology practice. It had been proposed to share etiological origin with eosinophilic esophagitis [EOE]. However, there is not yet adequate estimations of this association and incidence of NPs recurrence after endonasal surgery in patients with EOE. Aim of the work: To evaluate incidence of recurrence of NPs after endoscopic endonasal surgery for patients with EOE. Patients and Methods: 150 patients were included and divided into three groups: the control [CG] [50 patients indicated for gastroscopy]. The nasal polyp's subgroups consisted of 100 patients and further subdivided into two groups according to result of nasal biopsy into two subgroups, eosinophilic nasal polyps [ENP] group IIA; non-eosinophilic nasal polyps [NENP] group IIB. In NPs subgroups, sinonasal outcome test [SNOT22] had been performed to measure the health status and quality of life in patients with NPs through questions relating to their symptoms. The recurrence of nasal polyps were investigated after endoscopic sinus surgery and during follow up and outcome had been compared between groups. Results: 22% suffered polyp recurrence after surgery during the follow-up period. Patients with EOE had a significantly higher recurrence rate of nasal polyps [100%] in comparison to 16.4% in EOE patients. These results indicate that, mucosal eosinophilia is a determinant factor in the recurrence of nasal polyps. Hence in patients with EOE [had mucosal eosinophilia] who underwent endonasal surgery, the recurrence of nasal polyps should be highly expected. Conclusion: Mucosal eosinophilia in patients with EOE, and ENP are a more important prognostic factor in recurrence of nasal polyps.

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Section: Introductionmentioning

confidence: 99%

Incidence of Nasal Polyps Recurrence Rate in Patients with Eosinophilic Oesophagitis after Endoscopic Endonasal Surgery.

Sarhan

Fathallah

Wahba

et al. 2020

International Journal of Medical Arts

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“…Additionally, statistically significant correlations between post-exercise changes in FEV 1 /FVC and 3 h averages of PM 10 and NO 2 were present only in subjects with allergies. Allergic rhinitis, the most common allergic disorder in our study group, is connected with the inflammatory process within nasal mucosa [28]. By sharing inflammatory pathophysiology, allergy might affect respiratory responses to air pollution.…”

Section: Discussionmentioning

confidence: 82%

Exercise under Exposure to Air Pollution and Spirometry in Healthy Adults with and without Allergy

et al. 2021

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Ambient air pollution is a major environmental threat to human health. The acute effects of exposure to ambient air pollution during physical exercise may depend on allergy status. The aim of the study was to assess the acute respiratory responses to air pollution exposure during physical training in young adults with and without allergies. The studied group included 71 healthy young adults (n = 16 with allergy and n = 55 without allergy). Students completed two indoor physical training trials lasting 45–60 min: when air pollutants concentrations were high (exposure trial) and low (control trial). During each trial, we monitored outdoor and indoor environmental conditions. Participants performed spirometry at baseline and directly after the exercise. Exercise during exposure trials led to a small decrease in the percentage of predicted forced expiratory volume in 1 s (FEV1 ref). Only during the control trials did the FEV1/forced vital capacity quotient (FEV1/FVC) statistically significantly increase. Moreover, just in the allergy group, there were statistically significant negative correlations between post-exercise FEV1/FVC change and 3 h average outdoor particulate matter with aerodynamic diameter <10 µm (PM10) and nitrogen dioxide (NO2) concentrations (PM10: r = −0.54, p = 0.02, NO2: r = −0.60, p = 0.02). In young and healthy adults, sports training under exposure to high levels of ambient air pollutants leads to a small decrease in FEV1. The allergy might be a modifying factor in the respiratory responses to air pollution. Post-exercise decrease in FEV1/FVC was related to pre-exercise 3 h averages of PM10 and NO2 only in people with ever-diagnosed upper-respiratory allergy.

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“…Rhinitis is characterized by runny nose/rhinorrhea, nasal congestion, itching, and/or sneezing due to underlying inflammation of the nasal mucosa [ 161 , 163 , 164 , 165 ]. Patients with an allergic rhinitis usually have conjunctivitis and asthma [ 161 , 166 ].…”

Section: Clinically Relevant Molecular Applications Of Conjunctival Nasolacrimal and Nasal 3d Cell Culture Modelsmentioning

confidence: 99%

The Communication between Ocular Surface and Nasal Epithelia in 3D Cell Culture Technology for Translational Research: A Narrative Review

Aydin

Dietrich

Witt

et al. 2021

IJMS

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There is a lack of knowledge regarding the connection between the ocular and nasal epithelia. This narrative review focuses on conjunctival, corneal, ultrastructural corneal stroma, and nasal epithelia as well as an introduction into their interconnections. We describe in detail the morphology and physiology of the ocular surface, the nasolacrimal ducts, and the nasal cavity. This knowledge provides a basis for functional studies and the development of relevant cell culture models that can be used to investigate the pathogenesis of diseases related to these complex structures. Moreover, we also provide a state-of-the-art overview regarding the development of 3D culture models, which allow for addressing research questions in models resembling the in vivo situation. In particular, we give an overview of the current developments of corneal 3D and organoid models, as well as 3D cell culture models of epithelia with goblet cells (conjunctiva and nasal cavity). The benefits and shortcomings of these cell culture models are discussed. As examples for pathogens related to ocular and nasal epithelia, we discuss infections caused by adenovirus and measles virus. In addition to pathogens, also external triggers such as allergens can cause rhinoconjunctivitis. These diseases exemplify the interconnections between the ocular surface and nasal epithelia in a molecular and clinical context. With a final translational section on optical coherence tomography (OCT), we provide an overview about the applicability of this technique in basic research and clinical ophthalmology. The techniques presented herein will be instrumental in further elucidating the functional interrelations and crosstalk between ocular and nasal epithelia.

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Allergic and nonallergic rhinitis

Cited by 53 publications

References 0 publications

Incidence of Nasal Polyps Recurrence Rate in Patients with Eosinophilic Oesophagitis after Endoscopic Endonasal Surgery.

Incidence of Nasal Polyps Recurrence Rate in Patients with Eosinophilic Oesophagitis after Endoscopic Endonasal Surgery.

Exercise under Exposure to Air Pollution and Spirometry in Healthy Adults with and without Allergy

The Communication between Ocular Surface and Nasal Epithelia in 3D Cell Culture Technology for Translational Research: A Narrative Review

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