Allergic contact dermatitis caused by aftershave creams containing Glycyrrhiza inflata

Allergic contact dermatitis to Glycyrrhiza inflata root extract in an anti‐acne cosmetic product

“…Although liquorice derivatives are poorly absorbed through intact skin, 2 sensitization to them may be enhanced by previous skin damage. 2 We hypothesize that our patient initially developed contact dermatitis (irritant or allergic) to benzoyl peroxide and eventually developed sensitization and subsequently allergy contact dermatitis to G inflata root extract because the product containing it was introduced after the eczematous lesions had started. This case illustrates the importance of the cooperation of the manufacturers in investigating contact dermatitis from cosmetics to detect sensitization from emerging allergens.…”

“…1 Only rarely has allergic contact dermatitis to glycyrrhizic acid, oilsoluble liquorice-extracts and enoxolone in cosmetics been reported. 2 In two men, an aftershave cream with G inflata root extract applied on damaged (shaved) skin caused allergic contact dermatitis of the face. 2 Sensitization to benzoyl peroxide is uncommon, despite its wide use.…”

“…2 In two men, an aftershave cream with G inflata root extract applied on damaged (shaved) skin caused allergic contact dermatitis of the face. 2 Sensitization to benzoyl peroxide is uncommon, despite its wide use. However, it is known to be a strong irritant.…”

Natural ingredients in cosmetic products—A suggestion for a screening series for skin allergy

“…Liquorice is the root of plants belonging to the Fabaceae family, comprising more than 30 species, including Glycyrrhiza glabra and Glycyrrhiza inflata. 123 Liquorice is commonly used in pharmaceutical products, as a skin-whitening agent in cosmetics, and a skin conditioning agent in sunscreens. 123,124 Liquorice is available in water-soluble and oil-soluble versions.…”

“…123 Liquorice is commonly used in pharmaceutical products, as a skin-whitening agent in cosmetics, and a skin conditioning agent in sunscreens. 123,124 Liquorice is available in water-soluble and oil-soluble versions. Glabridin is considered the main active agent, which inhibits the production of melatonin within the melanocyte via inhibition of tyrosinase activity and promotes depigmentation.…”