Allergic contact dermatitis caused by isopropyl lauroyl sarcosinate

A case of generalized allergic contact dermatitis due to sodium lauroyl methylaminopropionate in a shampoo

“…3 However, several cases of ACD due to AAAAs, such as isopropyl lauroyl sarcosinate and oleoyl tyrosine, have recently been reported. 1,4,5 There have been four reported cases of ACD due to LMA, including our case. 2 One case involved an 18-yearold female with a history of atopic dermatitis, and the other three cases were in individuals over 50 years of age.…”

“…In 2017 the cosmetic ingredient review expert panel in the United States concluded that AAAAs are safe in the present concentrations in cosmetics 3 . However, several cases of ACD due to AAAAs, such as isopropyl lauroyl sarcosinate and oleoyl tyrosine, have recently been reported 1,4,5 . There have been four reported cases of ACD due to LMA, including our case 2 .…”

Allergic contact dermatitis to isopropyl lauroyl sarcosinate

“…Isopropyl lauroyl sarcosinate is used in oily vehicles to improve the solubility, efficacy, and photostability of ultraviolet filters 3 . To date, only one other case of allergic contact dermatitis has been published, concerning a Japanese woman who developed facial dermatitis after having applied a cosmetic containing this chemical 1 . Patch tests and ROAT with isopropyl lauroyl sarcosinate were positive on D3 (+) in this patient; however, four control patients tested negative with this chemical.…”

“…We report a second case of allergic contact dermatitis caused by isopropyl lauroyl sarcosinate (CAS no. 230309‐38‐3), an amino acid–based ester, contained in a cosmetic 1 …”

Oleoyl tyrosine: An emerging allergen in tan‐enhancing sunscreens and cosmetics

“…Besides, a cosmetic formulation containing capryloyl glycine 4% was recently found to be effective in the treatment of hypertrichosis 7 . Numata et al reported the first case of ACD from isopropyl lauroyl sarcosinate (a sarcosine derivative, closely related to glycine) in a facial leave‐on cosmetic, 8 and the same substance was recently highlighted as a culprit allergen in an anti‐acne product and in make‐up 9 . Sodium lauroyl sarcosinate and sodium myristoyl sarcosinate have provoked ACD due to their presence in ( “hypo‐allergenic”) hand and facial cleansers respectively, 10,11 also in the occupational setting 12 .…”