Allergic contact dermatitis from rectified camphor oil in Earex<sup>®</sup> ear drops

Stevenson, Olivia; Finch, Tracey M.

doi:10.1111/j.0105-1873.2003.0120l.x

Cited by 13 publications

(3 citation statements)

References 2 publications

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“…Menthol may cause contact allergy when in contact with skin or buccal mucosa presenting as chelitits or localized irritation (Wilkinson & Beck 1994;Foti 2003). Rare incidents of allergic contact dermatitis to camphor in ear drops and topical ointments were reported in the past (Stevenson & Finch 2003;Noiles & Pratt 2010).…”

Section: Discussionmentioning

confidence: 99%

Contact Dermatitis Following Use of Tropical Traditional Medicine

Muthupalaniappen¹,

Jamil²,

Chellathuray³

2016

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ABSTRAK ABSTRACTTraditional or herbal medications are generally perceived as safe since it is derived from natural or plant sources. A rise in number of adverse reactions are being reported with the use of traditional medications including localized cutaneous reactions. The diagnosis of contact dermatitis is often quite straight forward based on its appearance, pattern, site and distribution of the lesion which usually corresponds to the area of contact. We report the case of a 65-year-old woman who presented with redness, burning sensation and swelling of her hand after applying topical Chinese traditional medication. This report aims to outline simple measures to identify and manage contact dermatitis secondary to topical medication. The present case creates awareness that topical traditional medications are not as

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Section: Discussionmentioning

confidence: 99%

Contact Dermatitis Following Use of Tropical Traditional Medicine

Muthupalaniappen¹,

Jamil²,

Chellathuray³

2016

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“…General experimental procedures: 1 H, 13 C and 2D NMR spectra were recorded in CDCl 3 on Bruker DRX 400 and Bruker AC 200 (50.3 MHz for 13 C NMR) instruments at 295° K. Chemical shifts are given in ppm (δ) and were referenced to the solvent signals at δ 7.24 and 77.0 for 1 H and 13…”

Section: Methodsmentioning

confidence: 99%

“…However, due to their irritant properties, camphor and limonene were unable to induce an immunostimulatory response in the popliteal lymph node assay in rats [12]. A case report of an allergic contact dermatitis from rectified camphor oil as a component of a topical medicine has been previously published [13]. Still, it has been reported that T cell activation, proliferation, and cytokine gene transcription are all regulated by several transcription factors in which NF-κB shows a significant participation.…”

Section: Effects Of Terpenoids Of Salvia Willeana On Hypersensitivitymentioning

confidence: 99%

Effects of Terpenoids from Salvia Willeana in Delayed-type Hypersensitivity, Human Lymphocyte Proliferation and Cytokine Production

Vonaparti

Karioti

Recio

et al. 2008

Natural Product Communications

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The effect of the lipophilic extract of S. willeana and three terpenoids isolated therefrom, camphor, lupeol and oleanolic acid, on oxazolone-induced hypersensitivity was evaluated. The extract reduced the ear edema by 46% at 24 h after challenge. All three terpenoids inhibited the edema and suppressed cytokines release at different rates. Lupeol inhibited the swelling by over 50% and reduced the production of IL-1β by 62%. Camphor caused inhibition of the efferent phase (45% inhibition at 72 h) and the levels of IL-1β, IL-4 and TNF-α (around 80% inhibition). Oleanolic acid diminished moderately the reaction and the levels of IL-4 and TNF-α. We also demonstrated that the three terpenoids inhibited human T-lymphocytes proliferation in a concentration-dependent manner and induced their apoptosis. Thus, these terpenoids could be considered anti-inflammatory constituents of S. willeana.

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Kampfer [MAK Value Documentation in German language, 2013]

2013

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 55. Lieferung, Ausgabe 2013 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Bewertung

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Allergic contact dermatitis from rectified camphor oil in Earex^® ear drops

Cited by 13 publications

References 2 publications

Contact Dermatitis Following Use of Tropical Traditional Medicine

Contact Dermatitis Following Use of Tropical Traditional Medicine

Effects of Terpenoids from Salvia Willeana in Delayed-type Hypersensitivity, Human Lymphocyte Proliferation and Cytokine Production

Kampfer [MAK Value Documentation in German language, 2013]

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Allergic contact dermatitis from rectified camphor oil in Earex® ear drops

Cited by 13 publications

References 2 publications

Contact Dermatitis Following Use of Tropical Traditional Medicine

Contact Dermatitis Following Use of Tropical Traditional Medicine

Effects of Terpenoids from Salvia Willeana in Delayed-type Hypersensitivity, Human Lymphocyte Proliferation and Cytokine Production

Kampfer [MAK Value Documentation in German language, 2013]

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Allergic contact dermatitis from rectified camphor oil in Earex^® ear drops