Allergic diseases attributable to atopy in a population sample of Asian children

Wu, Caiyan; Huang, Hsin Yi; Pan, Wen Chi; Liao, Sui‐Ling; Hua, Man Chin; Tsai, Ming Han; Lai, Siang Hui; Yeh, Kuo Wei; Chen, Li Chen; Huang, Jing; Yao, Tsung Chieh

doi:10.1038/s41598-021-95579-2

Cited by 9 publications

(9 citation statements)

References 39 publications

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“…We used chi-square or the Fisher's exact test to detect significant differences between sensitization to CM, egg whites, or wheat, and Specific IgE between 0 and 0.34 kUA/L using ImmunoCAP or 0 and 26 LUs using MAST was considered negative [18,19]. For ImmunoCAP, positive sensitization (class 1-6) referred to values > = 0.35 kUA/L, and for MAST it referred to values > = 27 LUs [20,21]. Associated factors included singleton or multiple pregnancies, parity, meconium staining, maternal age, normal spontaneous delivery or cesarean section, birth length, body weight, head and chest circumferences, meconium passage, birth season, and weeks of gestation.…”

Section: Methodsmentioning

confidence: 99%

Perinatal Characteristics and the Sensitization to Cow Milk, Egg Whites and Wheat in Children up to 3 Years of Age

et al. 2023

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Food sensitization in early life identifies children at risk of developing allergic diseases. We investigated the sensitization to cow milk (CM), egg whites, and wheat. Newborns and infants under 3 years of age with available specific immunoglobulin E (sIgE) data were identified. A retrospective survey was conducted using data from the Chang Gung Research Database. Perinatal characteristics, such as singleton or multiples in a single pregnancy, parity, meconium staining, maternal age, spontaneous delivery or cesarean section, meconium passage, weeks of gestation, birth length, body weight, head and chest circumferences, and season, were obtained. The data on sIgE were collected, and a logistic regression model was used to determine the odds of sensitization. Positive sIgE for CM and egg whites was more likely to occur in boys than in girls. Early-life egg white and wheat sensitization was associated with increased birth body length and weight. A multivariate analysis indicated an association between egg white sIgE positivity and logarithmic total IgE. Higher total IgE levels and younger age were associated with egg white sensitization, and elevated weight and length at birth were linked to food sensitization, particularly to egg whites and wheat.

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Section: Methodsmentioning

confidence: 99%

Perinatal Characteristics and the Sensitization to Cow Milk, Egg Whites and Wheat in Children up to 3 Years of Age

et al. 2023

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“…Allergic disorders are type I hypersensitivity reactions, which are IgE-mediated immune responses against diverse antigens/allergens. This reaction is immediately provoked, and allergen/IgE-bound mast cells and basophils are essential components in atopy [ 1 , 2 , 3 , 4 ]. In immunological cells, IgE is crosslinked to FceRI, which activates signaling cascades.…”

Section: Introductionmentioning

confidence: 99%

Antiallergic Effects of Callerya atropurpurea Extract In Vitro and in an In Vivo Atopic Dermatitis Model

Choi

Lee

Manilack

et al. 2023

Plants

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(1) Background: Callerya atropurpurea is found in Laos, Thailand, and Vietnam. Although the anti-inflammatory action of C. atropurpurea has been investigated, the functions of this plant in allergic responses are not understood. Here, we explored the antiallergic mechanism of C. atropurpurea ethanol extract (Ca-EE) using in vitro assays and an in vivo atopic model. (2) Methods: The constituents of Ca-EE were analyzed using GC/MS. Inhibition of lipoxygenase and β-hexosaminidase activity was examined, and the expression of inflammatory genes was measured by quantitative real-time PCR. The regulatory roles of Ca-EE in IgE/FcεRI signaling were examined by Western blotting. The DNCB-induced atopic dermatitis mouse model was performed with histological analysis. (3) Results: Ca-EE comprised cis-raphasatin, lupeol, some sugars, and fatty acids. In RBL-2H3 cells, treatment with Ca-EE significantly reduced the activities of lipoxygenase and β-hexosaminidase, as well as cytokine gene expression. IgE-mediated signaling was downregulated by blocking Lyn kinases. Moreover, Ca-EE effectively inhibited allergic symptoms in the DNCB-induced atopic dermatitis model without toxicity. (4) Conclusions: Ca-EE displayed antiallergic activities through regulating IgE/Lyn signaling in RBL-2H3 cells and a contact dermatitis model. These results indicate that Ca-EE could be effective for allergic disease treatment.

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“…This upward trend is not limited to developed nations but also affects developing countries like China. The escalating burden of allergic diseases poses substantial challenges to public health systems and necessitates effective prevention and treatment strategies [4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

Allergy Burden in Sichuan, China: Investigating Prevalence, Patterns, and Population Attributable Risks among Children

Li¹,

Li²,

Yang³

et al. 2023

Preprint

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Background：Allergic diseases are increasing globally, including in China. This poses challenges to public health. Our study aimed to investigate allergens in children from Sichuan Province and their impact on dermatitis, rhinitis, and asthma. Methods：This retrospective study analyzed the medical records of 3204 pediatric patients aged 0-9 years at XXX. Serum samples were collected and tested using a microfluidic-based enzyme-linked immunoassay. The analysis focused on detecting allergen-specific immunoglobulin E for 20 food allergens and aeroallergens. Results：In this study, the proportions of children allergic to at least one allergen varied across different age groups. For children aged <1 year, 1-3 years, and 3-9 years, the proportions were 40.40%, 68.54%, and 37.66%, respectively. Boys showed a higher susceptibility to atopic allergies compared to girls (P<0.001). The prevalence of both food allergens and aeroallergens was high among the study participants. Among the food allergens, egg white (52.25%) and cow’s milk (39.33%) were the most prevalent, while Dermatophagoides pteronyssinus (41.88%) and Dermatophagoides farina (35.23%) were the most commonly observed aeroallergens. The intensity scores of food allergens decreased with increasing age, while the intensity scores of aeroallergens exhibited the opposite trend. The population attributable risk (PAR) of atopy for dermatitis was lower in the 3-9 years age group (40.10%) compared to younger children (<1 year: 63.40%; 1-3 years: 65.10%). Conclusions：The prevalence of atopic allergies varies with age and gender. Additionally, the intensity of food allergens and aeroallergens shows an age-related pattern. The proportion of dermatitis, rhinitis, and asthma that can be attributed to atopy remains consistently high across all age groups. However, there are differences in the population attributable risk (PAR) of atopy for dermatitis and asthma among different age groups.

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Allergic diseases attributable to atopy in a population sample of Asian children

Cited by 9 publications

References 39 publications

Perinatal Characteristics and the Sensitization to Cow Milk, Egg Whites and Wheat in Children up to 3 Years of Age

Perinatal Characteristics and the Sensitization to Cow Milk, Egg Whites and Wheat in Children up to 3 Years of Age

Antiallergic Effects of Callerya atropurpurea Extract In Vitro and in an In Vivo Atopic Dermatitis Model

Allergy Burden in Sichuan, China: Investigating Prevalence, Patterns, and Population Attributable Risks among Children

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