Allergic diseases – current state of knowledge

Żukiewicz-Sobczak, Wioletta; Krasowska, Dorota; Zwoliński, Jacek; Sobczak, Paweł; Chmielewska-Badora, Jolanta; Wróblewska, Paula; Piątek, Jacek; Wojtyła, Andrzej

doi:10.5114/pdia.2012.32393

Cited by 24 publications

(19 citation statements)

References 11 publications

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“…Chronic allergic inflammation, in the past called allergy, is excessive and changed response of the immune system, that definition was introduced by K. von Pirquet in 1906 [18]. Currently it is used as a synonym for temporary or permanent disturbances of immunoregulation causing incorrectly addressed immune response against a variety of allergens, leading to tissue damage.…”

Section: Discussionmentioning

confidence: 99%

Clinical immunology Examination of correlation between vitamin D3 (25-OHD3) concentration and percentage of regulatory T lymphocytes (FoxP3) in children with allergy symptoms

Kalicki¹,

Lewicki²,

Stankiewicz³

et al. 2013

cejoi

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Populations of T lymphocytes cells called regulatory T lymphocytes (Tregs) play a key role in the formation and maintenance of immune tolerance. This phenotypically heterogeneous group of cells regulates the immune system and plays an important role in tumor immunology, transplant immunology and the pathogenesis of multiple disorders, in particular autoimmune diseases. In the study it was decided to investigate the difference in the correlation of levels of vitamin D 3 (25-OHD 3 ) with the percentage of Tregs cells (FoxP3+) in children with no symptoms of allergy (control group), and with symptoms of allergy. In addition, in both groups the phenotype of lymphocytes was identified. The results indicate a positive correlation between only in children with allergic symptoms (no correlation in the control group), along with a simultaneous significant reduction in the percentage of CD4 lymphocytes in this group.

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Section: Discussionmentioning

confidence: 99%

Clinical immunology Examination of correlation between vitamin D3 (25-OHD3) concentration and percentage of regulatory T lymphocytes (FoxP3) in children with allergy symptoms

Kalicki¹,

Lewicki²,

Stankiewicz³

et al. 2013

cejoi

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“…According to current forecasts, the incidence of allergic diseases will continue to grow. Poland is among countries with a high proportion of patients with allergies, and it is estimated that about 40% of Poles are suffering from allergies [ 1 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

Probiotic lactic acid bacteria and their potential in the prevention and treatment of allergic diseases

Żukiewicz-Sobczak

Wróblewska

Adamczuk

et al. 2014

cejoi

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Allergy is one of the most important and very common health problems worldwide. To reduce the proportion of people suffering from allergy, alternative methods of prevention and treatment are sought. The aim of this paper is to present the possibilities of probiotics in the prevention and treatment of allergic diseases.Probiotics are live microorganisms belonging mainly to the lactic acid bacteria. They modify the microflora of the human digestive system, especially the intestinal microflora. Prophylactic administration of probiotics in the early stages of life (naturally in breast milk or milk substitute synthetic compounds) is very important because intestinal microflora plays a huge role in the development of the immune system. Prevention of allergies as early as in the prenatal and postnatal periods provides huge opportunities for inhibiting the growing problem of allergy in emerging and highly developed societies. Effects of probiotic therapy depend on many factors such as the species of the microorganism used, the dose size and characteristics of the bacteria such as viability and capacity of adhesion to the intestinal walls. Authors of several studies showed beneficial effects of probiotics in the perinatal period, infancy, and also in adults in the prevention of atopic dermatitis or allergic rhinitis.Probiotics, due to their immunomodulatory properties and safety of use are a good, natural alternative for the prevention and treatment of many diseases including allergies. It is therefore important to explore the knowledge about their use and to carry out further clinical trials.

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“…Airway inflammation, airway remodeling and hyperresponsiveness are the fundamental components of pathogenesis that lead to symptoms and lung function changes in asthma [1, 2], which are often accompanied by formation of new blood vessels (angiogenesis). Vessel number and size, vascular surface area and vascular leakage are all increased in biopsies from patients with asthma.…”

Section: Introductionmentioning

confidence: 99%

Experimental research The effects of budesonide on angiogenesis in a murine asthma model

Sun

Wang²,

Li³

et al. 2013

aoms

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IntroductionThe aim of this study is to determine the effects and mechanisms of budesonide on angiogenesis in a murine asthma model.Material and methodsMurine asthma models were established and mice were divided into three groups: the model group (OVA-sensitized and challenged mice), the BUD group (budesonide-treated mice) and the PBS group (normal control mice). Mice in the BUD group were administered with inhaled budesonide (100 µg/kg) daily. The effects on airway inflammation, angiogenesis, expression of hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) were examined.ResultsAdministration of budesonide ameliorated allergic airway inflammation (2.90 ±0.18 vs. 4.80 ±0.20, p < 0.01) and significantly reduced the percentage vascularity (0.78 ±0.14 vs. 2.83 ±0.90, p < 0.01) compared with those in the asthmatic model mice. It also reduced the expression of HIF-1α (immunohistochemistry results: 71.70 ±1.40 vs. 89.60 ±0.79, p < 0.001; western blotting results: 0.88 ±0.41 vs. 0.97 ±0.47, p < 0.05), as well as that of VEGF (immunohistochemistry results: 26.30 ±1.03 vs. 93.30 ±1.54, p < 0.001; western blotting results: 1.12 ±0.22 vs. 2.08 ±0.30, p < 0.01). Percentage vascularity had positive correlation with both HIF-1α (r = 0.785, p < 0.01) and VEGF (r = 0.693, p < 0.01) expression. Furthermore, there is positive relationship between HIF-1α and VEGF expression (r = 0.641, p < 0.05).ConclusionsThe results demonstrate that budesonide has an important inhibitory effect on angiogenesis in asthma. Inhaled administration of budesonide achieved anti-angiogenic activity through inhibition of HIF-1α and VEGF expression. The results support a potential anti-remodeling role for budesonide in the treatment of human asthma.

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Allergic diseases – current state of knowledge

Cited by 24 publications

References 11 publications

Clinical immunology Examination of correlation between vitamin D3 (25-OHD3) concentration and percentage of regulatory T lymphocytes (FoxP3) in children with allergy symptoms

Clinical immunology Examination of correlation between vitamin D3 (25-OHD3) concentration and percentage of regulatory T lymphocytes (FoxP3) in children with allergy symptoms

Probiotic lactic acid bacteria and their potential in the prevention and treatment of allergic diseases

Experimental research The effects of budesonide on angiogenesis in a murine asthma model

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