Allergic hypersensitivity to red meat induced by tick bites: a French case report

Guillier, A.; Fauconneau, A.; Barruel, Françoise De; Guez, S.; Doutre, M.-S.

doi:10.1684/ejd.2015.2531

Cited by 7 publications

(9 citation statements)

References 8 publications

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“…4 The allergy is caused by IgE-ab to the galactose-alpha-1, 3-galactose (alpha-gal), a carbohydrate found in glycolipids and glycoproteins in mammals but lacking in humans and higher primates. 5 Alpha-gal is present in muscles, blood cells, parenchymal tissue, and secretion of nonprimate mammals and allergic reaction can occur upon exposure to wide range of mammalian products (e.g., meat, kidneys, milk, gelatin, and blood products). 3,6 The route of IgE sensitization is through human skin via tick bites (species, Ixodes ricinus, in Europe).…”

Section: Introductionmentioning

confidence: 99%

“…1,7 Cases of delayed anaphylactic reactions after consumption of red meat among adults was first recognized in the United State 2009. 5,11,12 Previously, there have been a few cases reported among children, but reports have now come from United States, Turkey, and Italy. 5,13 "Recall urticaria," a memory response at the site of the previous tick bite, was recently reported among adults with alpha-gal syndrome.…”

Section: Introductionmentioning

confidence: 99%

“…5,11,12 Previously, there have been a few cases reported among children, but reports have now come from United States, Turkey, and Italy. 5,13 "Recall urticaria," a memory response at the site of the previous tick bite, was recently reported among adults with alpha-gal syndrome. 14 This case report presents a Swedish 12-year-old boy with alpha-gal syndrome and highlights the recall urticaria phenomena.…”

Section: Introductionmentioning

confidence: 99%

“…Allergic reactions to red meat typically occur in the night, several hours after a meat dinner and can lead to various allergic symptoms 4 . The allergy is caused by IgE‐ab to the galactose‐alpha‐1, 3‐galactose (alpha‐gal), a carbohydrate found in glycolipids and glycoproteins in mammals but lacking in humans and higher primates 5 . Alpha‐gal is present in muscles, blood cells, parenchymal tissue, and secretion of non‐primate mammals and allergic reaction can occur upon exposure to wide range of mammalian products (e.g., meat, kidneys, milk, gelatin, and blood products) 3,6 .…”

Section: Introductionmentioning

confidence: 99%

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A pediatric case of tick‐bite–Induced meat allergy and recall urticaria

Saleem

Nilsson

2021

Clinical Case Reports

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A pediatric case of tick‐bite–Induced meat allergy and recall urticaria

Saleem

Nilsson

2021

Clinical Case Reports

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“…Bites by lone star ticks ( Amblyomma americanum ), prevalent in the south-eastern regions of the USA, are considered to be the primary cause of IgE antibody responses specific for alpha-gal in the USA [8]. In recent years, the alpha-gal syndrome has been diagnosed on several continents, including Europe [9–13]. In southern Sweden, the alpha-gal syndrome has been related to bites of Ixodes ricinus [9], which is also the most dominant tick species in Austria.…”

mentioning

confidence: 99%

Alpha-gal allergy after a tick bite in Austria

Pisazka

Duscher

Hodžić

et al. 2019

Wien Klin Wochenschr

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Summary Tick bites can cause the alpha-gal syndrome, which is characterized by delayed anaphylactic reactions mainly to red meat and offal due to IgE antibodies against mammalian galactose-alpha-1.3-galactose carbohydrate (alpha-gal). Ixodes ricinus bites are considered the primary cause of IgE antibody responses specific for alpha-gal in Europe. This article reports on a 51-year-old Austrian male who acquired a tick bite in Austria in spring 2017, which, within 48 h, resulted in prolonged inflammation of the skin area around the bite. The patient experienced an allergic reaction 3 months later approximately 8 h after eating a medium rare steak for dinner. The symptoms included an itchy rash on both sides of the torso and on both arms which persisted for several hours. In spring 2018, the patient suffered another tick bite. The patient’s skin reaction was similar to that of the previous year. In the following months, the patient experienced five episodes of severe allergic reactions, each during the night after having eaten beef for dinner. The symptoms included pruritic urticarial rash involving the entire body along with swollen hands, diarrhea, vomiting and in some episodes even shortness of breath. At the request of the patient, specific IgE antibodies against alpha-gal were determined, revealing a highly positive result (>100 kU/l). This brief report aims to raise awareness that recurrent delayed anaphylactic reactions to food can develop after tick bites.

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Food allergy and hypersensitivity reactions in children and adults—A review

et al. 2021

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Adverse reactions after food intake are commonly reported and a cause of concern and anxiety that can lead to a very strict diet. The severity of the reaction can vary depending on the type of food and mechanism, and it is not always easy to disentangle different hypersensitivity diagnoses, which sometimes can exist simultaneously. After a carefully taken medical history, hypersensitivity to food can often be ruled out or suspected. The most common type of allergic reaction is immunoglobulin E (IgE)–mediated food allergy (prevalence 5–10%). Symptoms vary from mild itching, stomach pain, and rash to severe anaphylaxis. The definition of IgE‐mediated food allergy is allergic symptoms combined with specific IgE‐antibodies, and therefore only IgE‐antibodies to suspected allergens should be analyzed. Nowadays, methods of molecular allergology can help with the diagnostic process. The most common allergens are milk and egg in infants, peanut and tree nuts in children, and fish and shellfish in adults. In young children, milk/egg allergy has a good chance to remit, making it important to follow up and reintroduce the food when possible. Other diseases triggered by food are non‐IgE‐mediated food allergy, for example, eosinophilic esophagitis, celiac disease, food protein‐induced enterocolitis syndrome, and hypersensitivity to milk and biogenic amines. Some of the food hypersensitivities dominate in childhood, others are more common in adults. Interesting studies are ongoing regarding the possibilities of treating food hypersensitivity, such as through oral immunotherapy. The purpose of this review was to provide an overview of the most common types of food hypersensitivity reactions.

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Allergic hypersensitivity to red meat induced by tick bites: a French case report

Cited by 7 publications

References 8 publications

A pediatric case of tick‐bite–Induced meat allergy and recall urticaria

A pediatric case of tick‐bite–Induced meat allergy and recall urticaria

Alpha-gal allergy after a tick bite in Austria

Food allergy and hypersensitivity reactions in children and adults—A review

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