Allergic Rhinitis and Its Relationship with IL-10, IL-17, TGF-<i>β</i>, IFN-<i>γ</i>, IL 22, and IL-35

Değirmenci, Papatya Bayrak; Aksun, Saliha; Altın, Zeynep; Bilgir, Ferda; Arslan, İlker Burak; Çolak, Hülya; Ural, Basak Burcu; Kahraman, Dudu Solakoğlu; Diniz, Gülden; Özdemir, Binnaz Handan; Kırmaz, Cengiz

doi:10.1155/2018/9131432

Cited by 54 publications

(63 citation statements)

References 37 publications

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“…Our ndings are in agreement with the majority of clinical studies investigating IL-22 level in patients with allergic rhinitis and/ or allergic asthma and revealed that concentration of IL-22 in serum or plasma was higher in these patients than in healthy subjects (22)(23)(24)(25)(26)(27). Though, studies investigating local IL-22 level provided controversial results.…”

Section: Discussionsupporting

confidence: 88%

“…Some experimental studies showed that ovalbumin-challenged and IL-22-de cient mice had a low level of eosinophils in bronchoalveolar lavage and lung tissue and reduced leukocyte in ltration (31). In contrary, some other studies with animals reported that after ovalbumin stimulation IL-22-positive mice had a reduced number of eosinophils in the bronchoalveolar lavage when compared with IL-22-negative mice (28,29 (22). As mentioned before, these differences between studies could be determined by relatively small studies samples, different methods of IL-22 investigation and use of different tools for investigating severity of symptoms.…”

Section: Discussionmentioning

confidence: 99%

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Role of IL-22 in Persistent Allergic Airway Diseases Caused by House Dust Mite: A Pilot Study

Tamašauskienė

Gintauskienė

Bastyte

et al. 2020

Preprint

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Background. Persistent allergic airway diseases cause a great burden worldwide. Their pathogenesis is not clear enough. There is evidence that one of the recently described cytokine interleukin (IL) 22 may be involved in the pathogenesis of these diseases. Scientists argue if this cytokine acts as proinflammatory or anti-inflammatory agent. The aim of this study was to investigate IL-22 level in patients with persistent allergic airway diseases caused by house dust mite (HDM) in comparison with healthy individuals and to evaluate its relationship with IL-13 and IL-10 level, symptoms score and quality of life.Methods. Patients with persistent allergic rhinitis caused by HDM and having symptoms for at least 2 years with or without allergic asthma were involved into the study. Measurements of IL-22, IL-13 and IL-10 and in serum and nasal lavage was performed by ELISA. Questionnaires assessing symptoms severity and quality of life were used.Results. A tendency was observed that IL-22 in serum and nasal lavage was higher in patients with allergic airway diseases compared to control group (14.86 pg/ml vs. 7.04 pg/ml and 2.67 pg/ml vs. 1.28 pg/ml, respectively). Positive statistically significant correlation was estimated between serum IL-22 and serum IL-10 (rs=0.57, p<0.01) and IL-13 (rs=0.44, p<0.05) level. Moreover, positive significant correlation was found between IL-22 in nasal lavage and IL-10 in nasal lavage (rs=0.37, p<0.05). There was a negative statistically significant correlation between serum IL-22 and RQLQ (rs=-0.42, p<0.05).Conclusion. Our study showed a possible anti-inflammatory effect of IL-22 in patients with persistent allergic airway diseases caused by HDM.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Role of IL-22 in Persistent Allergic Airway Diseases Caused by House Dust Mite: A Pilot Study

Tamašauskienė

Gintauskienė

Bastyte

et al. 2020

Preprint

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“…Previous studies showed an elevated level of histamine, IgE, TNFand IL-1 in the serum of OVA-sensitized mice (Zhang, Li, Jia, & He, 2015). Other studies showed up-regulation of IL-10 and IFN-in serum in patients with AR compared with a normal population (Bayrak Degirmenci et al, 2018;Uguz, Sanlioglu, Yuzbey, Coskun, & Yegin, 2005). In order to further investigate whether OVA induction could increase the expression level of histamine and other OVA-specific inflammatory factors in vivo, blood specimens were collected on day 21, 24, 27 and 30 followed by ELISA assays, as illustrated in Figure 2.…”

Section: Up-regulation Of Histamine and Inflammatory Factors In Ova-smentioning

confidence: 93%

MiR‐199‐3p–Dnmt3a–STAT3 signalling pathway in ovalbumin‐induced allergic rhinitis

Cui

Guo

Wang

et al. 2019

Experimental Physiology

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New Findings What is the central question of this study?What is the mechanism of DNA methylation in allergic rhinitis? What is the main finding and its importance?A miR‐199‐3p–Dnmt3a–STAT3 signalling pathway is involved in ovalbumin‐induced allergic rhinitis, and miR‐199‐3p antagomir can relieve the symptoms in the mouse model. Abstract Recent research has pointed out the involvement of epigenetic modifications in allergic rhinitis (AR), especially DNA methylation. However, the detailed mechanism has remained largely uncovered. We used ovalbumin (OVA) to induce AR in mouse, and behaviour scores were used to confirm its successful establishment. Histamine and other inflammatory factors were detected to further verify success of the model. Real‐time PCR was employed to identify the overexpression of miR‐199‐3p and subsequent down‐regulation of DNA methyltransferase 3a (Dnmt3a). Western blotting was utilized to detect Dnmt3a and signal transducer and activator of transcription 3 (STAT3) at the protein level. Bisulfite sequencing PCR was applied to reveal the methylation status of the Stat3 promoter region. A dual‐reporter assay was used to confirm the direct targeting of miR‐199‐3p on the Dnmt3a mRNA and an antagomir specific to miR‐199‐3p was injected to rescue the symptoms of AR. The AR model was successfully established in mouse and confirmed by both behaviour and molecular markers. We also found lowered expression of Dnmt3a and consecutive hypomethylation of Stat3 promoter and elevated expression of STAT3, which then led to overexpression of IgE and other inflammatory factors. MicroRNAs that worked on the Dnmt3a 3′‐untranslated region were predicted and then verified by dual‐reporter assay. Finally injection of a miR‐199‐3p antagomir successfully attenuated the symptoms of AR. We propose that the miR‐199‐3p–Dnmt3a–STAT3 signalling pathway is involved in OVA‐induced AR.

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“…The overexpression of the IL-4, through genetic variation in regulatory regions and its physiological functions, gives it a preeminent role and responsibility for allergic inflammation. Perhaps this IL-4 role is part of a complex relationship between different ILs secreted by TH1 and TH2 and even the newly proposed cells, namely Th17 cells, which are a distinct subpopulation of CD4+ T cells that produce IL-17A, IL-17F, IL-22, TNF-α, and IL-21 [27]. Such a role can demonstrate the distinctive and enduring histological, pathophysiological, and clinical features of allergic inflammation, particularly of AR [10].…”

Section: Introductionmentioning

confidence: 97%

Association of IL-4 Polymorphisms with Allergic Rhinitis in Jordanian Population

et al. 2020

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Background and objectives: Allergic rhinitis has complex patterns of inheritance, and single nucleotide polymorphisms, a common genetic variation in a population, exert a significant role in allergic rhinitis pathology. The current study aimed to investigate the association of Interleukin-4 (IL-4) polymorphisms with allergic rhinitis. Materials and Methods: Our study included 158 patients with allergic rhinitis and 140 healthy controls from Jordan that were genotyped for IL-4 single nucleotide polymorphisms (SNPs) C-589T (rs2243250) and T-2979G (rs2227284) using restriction fragment length polymorphism-polymerase chain reaction. Statistical analysis was conducted using IBM SPSS Statistics version 24 software. Results: The results showed that the allelic frequency of the minor alleles was 0.19 and 0.67 for C-589T (rs2243250) and T-2979G (rs2227284) in the allergic rhinitis patients, respectively, while it was 0.18 for C-589T (rs2243250) and 0.64 T-2979G (rs2227284) in the control group. The homozygous (TT) genotype of C-589T (rs2243250) was significantly associated with allergic rhinitis (p < 0.05), while there was no association of any of T-2979G (rs2227284) genotypes with allergic rhinitis. Conclusions: The results of this study indicate that genetic inter-population variation precipitates the differences in the percentages of many diseases among populations, including allergic rhinitis.

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Allergic Rhinitis and Its Relationship with IL-10, IL-17, TGF-β, IFN-γ, IL 22, and IL-35

Cited by 54 publications

References 37 publications

Role of IL-22 in Persistent Allergic Airway Diseases Caused by House Dust Mite: A Pilot Study

Role of IL-22 in Persistent Allergic Airway Diseases Caused by House Dust Mite: A Pilot Study

MiR‐199‐3p–Dnmt3a–STAT3 signalling pathway in ovalbumin‐induced allergic rhinitis

Association of IL-4 Polymorphisms with Allergic Rhinitis in Jordanian Population

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