Allergic rhinitis impairs working memory in association with drop of hippocampal – Prefrontal coupling

Salimi, Morteza; Ghazvineh, Sepideh; Nazari, Milad; Dehdar, Kolsoum; Garousi, Mani; Zare, Mahdi; Tabasi, Farhad; Jamaati, Hamidreza; Salimi, Alireza; Barkley, Victoria; Mirnajafi‐Zadeh, Javad; Raoufy, Mohammad Reza

doi:10.1016/j.brainres.2021.147368

Cited by 17 publications

(13 citation statements)

References 81 publications

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“…LFPs were simultaneously obtained from OB, EC, and dHPC via a fixed miniature buffer head stage with high-input impedance (BIODAC-A, TRITA Health Technology Co., Tehran, Iran). The signals were amplified using 1000 amplification gain, low-pass filtered < 250 Hz, and digitized at 1 kHz through a recording system (BIODAC-ESR18622, TRITA Health Technology Co., Tehran, Iran) 78 , 79 . EEG lab toolbox was applied for pre-processing the signals, including noise rejection and baseline correction 80 .…”

Section: Methodsmentioning

confidence: 99%

Disrupted connectivity in the olfactory bulb-entorhinal cortex-dorsal hippocampus circuit is associated with recognition memory deficit in Alzheimer’s disease model

Salimi

Tabasi

Abdolsamadi

et al. 2022

Sci Rep

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Neural synchrony in brain circuits is the mainstay of cognition, including memory processes. Alzheimer's disease (AD) is a progressive neurodegenerative disorder that disrupts neural synchrony in specific circuits, associated with memory dysfunction before a substantial neural loss. Recognition memory impairment is a prominent cognitive symptom in the early stages of AD. The entorhinal–hippocampal circuit is critically engaged in recognition memory and is known as one of the earliest circuits involved due to AD pathology. Notably, the olfactory bulb is closely connected with the entorhinal–hippocampal circuit and is suggested as one of the earliest regions affected by AD. Therefore, we recorded simultaneous local field potential from the olfactory bulb (OB), entorhinal cortex (EC), and dorsal hippocampus (dHPC) to explore the functional connectivity in the OB-EC-dHPC circuit during novel object recognition (NOR) task performance in a rat model of AD. Animals that received amyloid-beta (Aβ) showed a significant impairment in task performance and a marked reduction in OB survived cells. We revealed that Aβ reduced coherence and synchrony in the OB-EC-dHPC circuit at theta and gamma bands during NOR performance. Importantly, our results exhibit that disrupted functional connectivity in the OB-EC-dHPC circuit was correlated with impaired recognition memory induced by Aβ. These findings can elucidate dynamic changes in neural activities underlying AD, helping to find novel diagnostic and therapeutic targets.

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Section: Methodsmentioning

confidence: 99%

Disrupted connectivity in the olfactory bulb-entorhinal cortex-dorsal hippocampus circuit is associated with recognition memory deficit in Alzheimer’s disease model

Salimi

Tabasi

Abdolsamadi

et al. 2022

Sci Rep

Self Cite

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“…It has been documented that in animal models of AR, the oscillation frequencies of both gamma and theta at the plPFC are reduced, and the correlation between vHipp and plPFC in the gamma and theta frequency bands is also reduced, resulting in reduced information exchange between vHipp and plPFC. The Disrupted functional coupling between vHipp and plPFC causes memory impairment (Salimi et al, 2021).…”

Section: Ar and Cognitive Dysfunctionmentioning

confidence: 99%

“…Furthermore, the occurrence of the above brain function-related symptoms also increases the difficulty and expenditure of diagnosis and treatment of AR (Ozdoganoglu et al, 2012;Salimi et al, 2019Salimi et al, , 2021. Thus, the prevention and therapy of brain function-related symptoms in AR are of great significance.…”

Section: Introductionmentioning

confidence: 99%

“…In addition to the typical nasal symptoms above, AR can further lead to hyposmia, anxiety, depression, cognitive impairment, memory loss, sleep disorders, and other brain function‐related symptoms, which have a serious impact on the life of patients and bring a heavy burden to the patient's family and society at the same time. Furthermore, the occurrence of the above brain function‐related symptoms also increases the difficulty and expenditure of diagnosis and treatment of AR (Ozdoganoglu et al, 2012; Salimi et al, 2019, 2021). Thus, the prevention and therapy of brain function‐related symptoms in AR are of great significance.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Brain response in allergic rhinitis: Profile and proposal

Wang

Song

Wei

et al. 2022

J of Neuroscience Research

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In addition to typical nasal symptoms, patients with allergic rhinitis (AR) will further lead to symptoms related to brain function such as hyposmia, anxiety, depression, cognitive impairment, memory loss, etc., which seriously affect the quality of life of patients and bring a heavy burden to the patient's family and society. Some scholars have speculated that there may be potential “nose‐brain communication” mechanism in AR that rely on neuro‐immunity. This mechanism plays an important role in AR‐associated brain response process. However, no study has directly demonstrated which neural circuits will change in the connection between the nose and brain during the onset of AR, and the mechanism which underlines this question is also lack. Focusing on the topic of “nose‐brain communication”, this paper systematically summarizes the latest research progress between AR and related brain responses and discusses the mechanism of AR‐related neurological phenotypes. Hope new diagnostic and therapeutic targets to ameliorate the brain function‐related symptoms and improve the quality of life of AR patients will be developed.

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“…The interaction of rhythms in different frequency bands is generally called cross-frequency coupling (CFC). The most famous example of CFC is in the hippocampus, where the amplitude of the γ oscillation is modulated by the θ rhythm ( Li et al, 2019 ; Nakazono et al, 2019 ; Salimi et al, 2021 ). Recent studies have shown that this θ- γ coupling reflects the general mechanism of dynamic information processing in the brain and the strength of coupling changes during learning, long-term, and working memory processes ( van Wingerden et al, 2014 ; Griffiths et al, 2019 ; Jones et al, 2020 ; Vivekananda et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Odor-induced modification of oscillations and related theta-higher gamma coupling in olfactory bulb neurons of awake and anesthetized rats

et al. 2022

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Olfactory gamma oscillations (40–100 Hz) are generated spontaneously in animals and represent the activity of local olfactory bulb (OB) networks, which play important roles in cognitive mechanisms. In addition, high-frequency oscillations (HFO, 130–180 Hz) have attracted widespread attention and are novel neuronal oscillations with a frequency range closer to high gamma oscillations (60–100 Hz, HGOs). Both HGOs and HFOs are distinctly regulated by θ rhythm in the hippocampus. To understand their mediation mechanisms in the OB, we investigated whether local field potential (LFP) oscillations including HGOs and HFOs and even their coupling with theta rhythm are modified by odor stimulation in both freely moving and anesthetized rats. Therefore, we combined electrophysiological technology and cross-frequency coupling analysis approaches to determine the difference in the odor-modulated LFP oscillations between awake and anesthetized rats. The obtained results indicate that LFP oscillations including HGOs and HFOs were differently modified by odor stimulation in animals of both states. However, θ-HGO and θ-HFO coupling were modified in only awake animals. It is suggested that these oscillations and their interactions with theta oscillations may play crucial roles in olfactory network activity. This could pave the way for further understanding the underlying mechanisms of oscillations in OB neurons towards odor sensation.

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Allergic rhinitis impairs working memory in association with drop of hippocampal – Prefrontal coupling

Cited by 17 publications

References 81 publications

Disrupted connectivity in the olfactory bulb-entorhinal cortex-dorsal hippocampus circuit is associated with recognition memory deficit in Alzheimer’s disease model

Disrupted connectivity in the olfactory bulb-entorhinal cortex-dorsal hippocampus circuit is associated with recognition memory deficit in Alzheimer’s disease model

Brain response in allergic rhinitis: Profile and proposal

Odor-induced modification of oscillations and related theta-higher gamma coupling in olfactory bulb neurons of awake and anesthetized rats

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