Allergie et transfusion

Mertès, Paul-Michel; Boudjedir, Karim

doi:10.1016/j.tracli.2013.02.023

Cited by 7 publications

(2 citation statements)

References 27 publications

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“…Le cas classiquement rapporté de patients déficitaires en IgA sérique manifestant une allergie aux IgA apportés par les fractions plasmatiques des PSL et par le PFC-MDS (les autres MDS sont en principe déplétés en IgA) pose question sur le plan de la physiopathologie et la mécanique de l'allergie : une analyse très récente remet sérieuse-ment la nature allergique de ce déficit IgA [74]. Quelques revues récentes font le point sur le sujet [75,76], mais il semble que ce sujet soit encore largement à explorer sur le plan mécanistique.…”

Section: L'état Des Lieuxunclassified

Transfusion et inflammation : hier – aujourd’hui – demain

Garraud

Hamzeh‐Cognasse

Laradi

et al. 2015

Transfusion Clinique et Biologique

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Section: L'état Des Lieuxunclassified

Transfusion et inflammation : hier – aujourd’hui – demain

Garraud

Hamzeh‐Cognasse

Laradi

et al. 2015

Transfusion Clinique et Biologique

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“…There are no reliable estimates regarding the incidence of plasma proteins induced ATR, and chemical products ATR since such cases are rarely identified. Some reports have suggested that food allergens in blood components could play a role in ATR, but clear evidence has yet to be established (4,(6)(7)(8)(9). These triggers may induce IgE bridging on the FcϵRI and activate degranulation of mastocytes and/or basophils.…”

Section: Introductionmentioning

confidence: 99%

Pilot study on the use of basophil activation tests and skin tests for the prevention of allergic transfusion reactions

Akiki,

Dedeken,

Ferster

et al. 2024

Front. Allergy

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Background and objectivesManagement of severe allergic transfusion reactions (ATR) is challenging. In this study, we investigate the usefulness of skin tests and basophil activation tests (BAT) in chronically transfused patients for the prevention of future ATR.Materials and methodsBAT and skin tests were carried with the supernatant of red blood cell (RBC) units for a sickle-cell disease patient under chronic exchange transfusion who has presented a severe ATR, in order to prevent potential future ATR. If the results for both BAT and skin tests were negative, the RBC units could be transfused to the patient. If either one of the results was positive, the tested RBC unit was discarded for the patient.Results192 RBC units were tested with both tests. The level of results concordance between the two tests was 95%. Out of the 169 negative units with both tests, 118 units were transfused to the patient for which he presented no ATR.ConclusionIn our study, combining both BAT and skin tests was associated with a good negative predictive value since we were able to safely transfuse our patient. Further studies are still necessary to confirm this result but this pilot study indicates that skin tests and BAT might help prevent ATR. When BAT is not available, skin tests may also be useful in preventing ATR.

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