Allergy as a Contributing Factor to Biologic Deafness

Mao, Chun-Yue

doi:10.1001/archotol.1942.00670010587005

Cited by 9 publications

(3 citation statements)

References 6 publications

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“…Reviewing the literature, we found that many epidemiologic studies were conducted to support the existence of a relationship between OM and atopic disease. Using objective intradermal and in vitro testing, many investigators have demonstrated a high prevalence of OME among atopic patients: Dohlman (56%) [33], Mao (29%) [34], Jordan (74%) [35], Solow (72%) [36], Lecks (88%) [37] [48••]. In our study, conducted in children 5 to 6 years of age, 60% of those with OME were atopic, while 40% were nonatopic.…”

Section: Role Of Atopymentioning

confidence: 56%

Audiological Investigation of Otitis Media in Children with Atopy

Martines

Bentivegna

2011

Curr Allergy Asthma Rep

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Otitis media (OM) describes an inflammatory process within the middle ear space that is generally associated with accumulation of fluid and that may lead to hearing loss, learning difficulties, and delays in language development. The pathogenesis of OM is multifactorial, involving the adaptive and native immune system, eustachian tube dysfunction, viral and bacterial load, and genetic and environmental factors. The involvement of IgEmediated allergic reactions in the pathogenesis of OM has been suggested by clinical observations of a high prevalence of OM among patients with allergies. Evidence from studies involving tympanometric measurements, audiometric measurements, and otoscopic examination confirms the role of atopy in the development and persistence of OM.

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Section: Role Of Atopymentioning

confidence: 56%

Audiological Investigation of Otitis Media in Children with Atopy

Martines

Bentivegna

2011

Curr Allergy Asthma Rep

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“…During the past 60 years, only 11 investigators have used IDT to evaluate their entire patient populations (Table I). 3,4,6,24,25,[28][29][30][31][32][33]…”

Section: Literature Reviewmentioning

confidence: 99%

Association of Otitis Media With Effusion and Allergy as Demonstrated by Intradermal Skin Testing and Eosinophil Cationic Protein Levels in Both Middle Ear Effusions and Mucosal Biopsies

Hurst

1996

The Laryngoscope

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This study was performed to ascertain the role of allergy, as defined by skin testing and histochemical markers, in the pathogenesis of otitis media with effusion (OME). A historical perspective of allergy as it relates to OME is presented. The study included 89 patients: 48 with persistent effusion but no recent acute infection, 25 with purulent OME complicated by a superimposed infection, and 16 control subjects. All 89 patients had persistent effusion for more than 2 months and subsequently required the placement of tympanostomy tubes. Allergy was defined using the radioallergosorbent test (RAST), serum immunoglobulin E (IgE) levels, and skin tests. Allergies were present in 97% of the patients with nonacute OME. The relationship between allergy and OME was corroborated clinically in 89% of patients and was also substantiated by elevated levels of effusion eosinophil cationic protein (ECP) in 87.5% of OME patients. Histologically, polyclonal antibody staining for ECP demonstrated the presence of eosinophils in middle ear mucosal biopsy specimens. This study confirms that OME is a sign of allergic inflammation in the middle ear that is associated with an increase in eosinophils and a concomitant release of ECP into the effusion in individuals with allergy demonstrated by skin testing.

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“…Mao 29 reviewed the results of tests for allergy on 535 resident pupils in the Pennsylvania School for the Deaf. Positive reactions were found in 28.5 per cent, while only 2 per cent showed defi¬ nite clinical manifestations.…”

Section: Allergy Of the Earmentioning

confidence: 99%

Allergy

MACQUIDDY¹

1944

Archives of Otolaryngology - Head and Neck Surgery

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Allergy as a Contributing Factor to Biologic Deafness

Cited by 9 publications

References 6 publications

Audiological Investigation of Otitis Media in Children with Atopy

Audiological Investigation of Otitis Media in Children with Atopy

Association of Otitis Media With Effusion and Allergy as Demonstrated by Intradermal Skin Testing and Eosinophil Cationic Protein Levels in Both Middle Ear Effusions and Mucosal Biopsies

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