Allergy or Tolerance: Reduced Inflammatory Cytokine Response and Concomitant IL-10 Production of Lymphocytes and Monocytes in Symptom-Free Titanium Dental Implant Patients

Thomas, Peter A.; Iglhaut, Gerhard; Wollenberg, Andreas; Cadosch, Dieter; Summer, Burkhard

doi:10.1155/2013/539834

Cited by 33 publications

(23 citation statements)

References 51 publications

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“…Yttria-stabilized zirconia does appear to meet all important requirements as patients and dentists increasingly seem to prefer metal-free solutions (Sivaraman, Chopra, Narayan, & Balakrishnan, 2018). This trend is driven by growing concerns among patients about titanium sensitivity, allergies, or intolerance, even though there is scarcely any evidence that these factors might be clinically relevant (Fage, Muris, Jakobsen, & Thyssen, 2016;Hosoki, Nishigawa, Miyamoto, Ohe, & Matsuka, 2016;Thomas, Iglhaut, Wollenberg, Cadosch, & Summer, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Titanium particles have been reported to cause degenerative changes in peri-implant tissue where they are phagocytosed by macrophages and neutrophils activated as part of the biological response (Fage et al, 2016;Noronha Oliveira et al, 2018;Thomas et al, 2013). Although recent studies have demonstrated a potential of titanium particles to cause inflammatory reactions in peri-implant tissue, hard evidence for a causal relationship is yet to be provided (Fretwurst, Nelson, Tarnow, Wang, & Giannobile, 2018;Mombelli, Hashim, & Cionca, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Two‐piece zirconia versus titanium implants after 80 months: Clinical outcomes from a prospective randomized pilot trial

Koller

Steyer

Theisen

et al. 2020

Clinical Oral Implants Res

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Objectives To prospectively evaluate, as part of an ongoing randomized pilot trial, the clinical outcomes of two‐piece zirconia implants in comparison with titanium implants 80 months after delivery of all‐ceramic (lithium disilicate) single‐tooth restorations. Material and methods The original sample included 31 (16 zirconia and 15 titanium) implants in 22 healthy patients. In addition to evaluating implant survival and success, a number of clinical or radiographic parameters were statistically analyzed: plaque index (PI), bleeding on probing (BOP), pink esthetic score (PES), and marginal bone loss (MBL). Both implant groups were compared using a Mann–Whitney U test. Results Three implants (2 zirconia and 1 titanium) had been lost, so that 28 implants (14 zirconia and 14 titanium) in 21 patients could be evaluated after a mean of 80.9 (SD: 5.5) months. All surviving implants had remained stable, in the absence of any fixture or abutment fractures and without any chipping, fracture, or debonding of crowns. The zirconia implants were associated with PI values of 11.07% (SD: 8.11) and the titanium implants with 15.20% (SD: 15.58), the respective figures for the other parameters being 16.43% (SD: 6.16) or 12.60% (SD: 7.66) for BOP; 11.11 (SD: 1.27) or 11.56 (SD: 1.01) for PES; and 1.38 mm (SD: 0.81) or 1.17 mm (SD: 0.73) for MBL. Conclusions No significant differences were found between the clinical outcomes of two‐piece zirconia and titanium implants based on the aforementioned parameters after 80 months of clinical service. Our results should be interpreted with the limited sample size in mind.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Two‐piece zirconia versus titanium implants after 80 months: Clinical outcomes from a prospective randomized pilot trial

Koller

Steyer

Theisen

et al. 2020

Clinical Oral Implants Res

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“…In another study (Thomas, Iglhaut, Wollenberg, Cadosch, & Summer, 2013), 14 healthy individuals without titanium implants and six individuals with titanium implants without complication showed no enhanced reactivity in terms of lymphocyte transformation. In another study (Thomas, Iglhaut, Wollenberg, Cadosch, & Summer, 2013), 14 healthy individuals without titanium implants and six individuals with titanium implants without complication showed no enhanced reactivity in terms of lymphocyte transformation.…”

Section: Soft Tissuementioning

confidence: 87%

“…and TNFα release assay scores (Jacobi-Gresser, Huesker, & Schutt, 2013). In another study (Thomas, Iglhaut, Wollenberg, Cadosch, & Summer, 2013), 14 healthy individuals without titanium implants and six individuals with titanium implants without complication showed no enhanced reactivity in terms of lymphocyte transformation. In an interesting manner, individuals without implants showed higher cytokine response (IL-1β, IL-6, TNFα, IL-10) to titanium than individuals with symptom-free implants.…”

Section: Soft Tissuementioning

confidence: 98%

What is the impact of titanium particles and biocorrosion on implant survival and complications? A critical review

Mombelli

Hashim

2018

Clinical Oral Implants Res

166

137

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Objectives To compile the current evidence regarding the association between the release of titanium particles and biologic complications of dental implants. Material and methods This is a critical review. We searched the literature using the terms “corrosion,” “allergy,” “hypersensitivity,” or “particles” together with “titanium,” “Ti,” “TiO2.” The bibliographies of identified publications and previously published review articles were scanned to find additional related articles. We included clinical studies, in vivo and in vitro experiments. Results Titanium particles and degradation products of titanium have been detected in oral and nonoral tissues. Particles are released from surfaces of dental implants because of material degradation in a process called tribocorrosion. It involves mechanical wear and environmental factors, notably contact to chemical agents and interaction with substances produced by adherent biofilm and inflammatory cells. In vitro, titanium particles can interfere with cell function and promote inflammation. A temporal association between exposure to titanium and occurrence of tissue reactions suggested hypersensitivity in a limited number of cases. However, there is poor specificity as the observed reactions could be initiated by other factors associated with the placement of implants. Titanium particles are commonly detected in healthy and diseased peri‐implant mucosa alike, at low levels even in gingiva of individuals without titanium implants. Rather than being the trigger of disease, higher concentrations of titanium in peri‐implantitis lesions could be the consequence of the presence of biofilms and inflammation. Conclusion There is an association between biocorrosion, presence of titanium particles, and biological implant complications, but there is insufficient evidence to prove a unidirectional causal relationship.

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“…Однако существенная частота положительных реакций на красители у здоровых лиц указывает на возможные контакты с ними при употреблении пищи, лекарств, косметики и последующее развитие гиперчувствительности к ним. Так, TiO 2 способен индуцировать первичный иммунный ответ в культуре мононуклеаров с выделением цитокинов IL-1β, IL-6 и TNFα [34].…”

Section: Discussionunclassified

Dyes in Food and Drugs Are Potential Immunomodulators

Aliakhnovich

Novikov

2019

Med. immunol.

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There are some data about various immunopathology effects of food dyes. Their use in food and medicines may induce hypersensitivity, which is regarded as a side effect of drugs or intolerance to food substances. Evaluation of the effect caused by food and drugs colorants on the immunity was conducted in 68 patients with chronic allergic diseases without the exacerbation and 23 healthy individuals. The provocative oral test was supplied with 2 mg of titanium dioxide (TiO2) in powder or 2 mg of tartrazine in wheat flour processed at a cooking temperature or in a gelatin capsule containing 0.2 mg of titanium dioxide. The oral fluid and/or venous blood were taken up on an empty stomach and 40 minutes after the test. The peroxidase activity of oral fluid and the expression of CD203c and IgE markers on blood basophils were studied. The blood of 20 patients with allergopathology was incubated for 3 and 24 hours with 0.001% and 0.01% mixture of tartrazine, carmoazine, ponso, sanset, TiO2 solutions with the determination interleukin 17 (IL17) level in the supernatants. Peroxidase activity of oral fluid increased on 30% or more in 30% of cases after tartrazine and wheat flour provocation in patients with allergies (12.5% in healthy persons), 44% - after TiO2 in patients with allergies (22% of cases in healthy individuals), 63% - after tartrazine and TiO2 in the white gelatin capsule in patients with allergies (in healthy individuals, p = 0.047). The number of IgE+CD203c+ basophils increased in 44% cases and decreased in 50% cases after provocation with TiO2 in the group of allergic patients, compared with 22% increasing and 22% decreasing in healthy (p = 0.007). A lower concentration of the dye mixture (0.001%) induced IL17 secretion in the supernatant in all 20 patients with allergic diseases, the maximum permissible concentration (0.01%) of the dyes solution - less often in 40% of the examined (p = 0.0002). Secretion of IL17 under the influence of the both concentrations was higher than in the control samples (p <0.05). Thus, the dyes of food and drugs show immunomodulatory activity in patients with allergic diseases (more often) and in healthy individuals. The connection of a positive provocation test with food dyes tartrazine and titanium dioxide with oral fluid peroxidase activity increasing and the number of IgE+CD203c+ basophils and IgEbright basophils increasing and IL17 secretion under the influence of these dyes was found.

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Allergy or Tolerance: Reduced Inflammatory Cytokine Response and Concomitant IL-10 Production of Lymphocytes and Monocytes in Symptom-Free Titanium Dental Implant Patients

Cited by 33 publications

References 51 publications

Two‐piece zirconia versus titanium implants after 80 months: Clinical outcomes from a prospective randomized pilot trial

Two‐piece zirconia versus titanium implants after 80 months: Clinical outcomes from a prospective randomized pilot trial

What is the impact of titanium particles and biocorrosion on implant survival and complications? A critical review

Dyes in Food and Drugs Are Potential Immunomodulators

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