Alleviating VLDL overproduction is an important mechanism for Laminaria japonica polysaccharide to inhibit atherosclerosis in LDLr−/− mice with diet‐induced insulin resistance

Zha, Xue‐Qiang; Zhang, Weinan; Peng, Fu-Hua; Xue, Lei; Liu, Jian; Luo, Jian‐Ping

doi:10.1002/mnfr.201600456

Cited by 24 publications

(15 citation statements)

References 46 publications

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“…In current research, miRNA-FoxO1 interference decreased the relative gene expression and the protein content of CPT1 and ACOX1, which indicated that fatty acid oxidation decreased after FoxO1 interference, which is in line with a previous study that FoxO1 proteins exerted important effects on fatty acid oxidation via the regulation of adipose triacylglycerol lipase reported by Zhang et al (2016). Zha et al (2017) reported that regulating PI3K-Akt-Foxo1 signaling pathway mediated by insulin receptor substrate alleviated VLDL overproduction. In this study, FoxO1 interference decreased the gene expression of MTP and ApoB, decreased the protein content of MTP, decreased VLDL-TG secretion and increased the intracellular TG content, which led to excessive fat accumulation in the liver cells.…”

Section: Discussionsupporting

confidence: 90%

Forkhead box protein O1 (FoxO1) regulates lipids metabolism and cell proliferation mediated by insulin and PI3K-Akt-mTOR pathway in goose primary hepatocytes

Wei¹,

Han²,

Ye³

et al. 2022

Biocell

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In order to explore the role of forkhead box protein O1 (FoxO1) in the lipid metabolism and cell proliferation, goose primary hepatocytes were isolated and incubated with insulin or PI3K-Akt-mTOR pathway dual inhibitor NVP-BEZ235, and then transfected with FoxO1 interference plasmid. The related parameters of lipid metabolism and cell proliferation were measured. The results firstly showed that FoxO1 interference increased the intracellular TG and lipids concentration (P < 0.05); and increased the proliferative index (PI), cell DNA synthesis, protein expression of Cyclin D1 in goose primary hepatocytes (P < 0.05). Secondly, the co-treatment of insulin and FoxO1 interference increased the mRNA level and protein content of Cyclin D1 (P < 0.05); however, there was no significant difference between the insulin treatment and the co-treatment of insulin and miR-FoxO1 interference in the intracellular TG and lipids concentration and PI (P > 0.05). Lastly, the decrease of intracellular TG and lipids concentration and PI induced by NVP-BEZ235 was up-regulated by FoxO1 interference significantly (P < 0.05). In summary, FoxO1 could regulate the lipids metabolism and cell proliferation mediated by PI3K-Akt-mTOR signaling pathway in goose primary hepatocytes. Further investigations are required to highlight the potential role of FoxO1 in the lipid metabolism and cell proliferation mediated by insulin in goose primary hepatocyte.

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Section: Discussionsupporting

confidence: 90%

Forkhead box protein O1 (FoxO1) regulates lipids metabolism and cell proliferation mediated by insulin and PI3K-Akt-mTOR pathway in goose primary hepatocytes

Wei¹,

Han²,

Ye³

et al. 2022

Biocell

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“…However, because the roles of mTOR in lipogenesis and insulin signaling are also blocked, common side effects of their use are dyslipidemia and insulin resistance, which are both risk factors for atherosclerosis. In order to minimize these effects, which would lead to an increase of low-density lipoprotein cholesterol levels, additional use of cholesterol lowering drugs is a recommended strategy [195,196,197].…”

Section: Mtor and Age-related Diseasesmentioning

confidence: 99%

mTOR: A Cellular Regulator Interface in Health and Disease

Boutouja

Stiehm

Platta

2019

Cells

119

110

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The mechanistic target of Rapamycin (mTOR) is a ubiquitously-conserved serine/threonine kinase, which has a central function in integrating growth signals and orchestrating their physiologic effects on cellular level. mTOR is the core component of differently composed signaling complexes that differ in protein composition and molecular targets. Newly identified classes of mTOR inhibitors are being developed to block autoimmune diseases and transplant rejections but also to treat obesity, diabetes, and different types of cancer. Therefore, the selective and context-dependent inhibition of mTOR activity itself might come into the focus as molecular target to prevent severe diseases and possibly to extend life span. This review provides a general introduction to the molecular composition and physiologic function of mTOR complexes as part of the Special Issue “2018 Select Papers by Cells’ Editorial Board Members”.

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“…(1 (Figure 1) [13]. LJP61A has been proved to suppressing atherosclerosis via the regulation of cellular lipid metabolism, inhibition of cellular inflammation and alleviation of insulin resistance [13,14]. Additionally, we have demonstrated that LJP61A could ameliorate vascular calcification via preventing osteoblastic differentiation of vascular smooth muscle cells [15].…”

Section: Introductionmentioning

confidence: 87%

Renoprotective Effect of Laminaria japonica Polysaccharide in Adenine-Induced Chronic Renal Failure

Long

Fang

et al. 2019

Preprint

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Chronic renal failure (CRF) is a major public health problem worldwide. In this work, we investigated the effects of a purified Laminaria japonica polysaccharide (LJP61A) on the renal function using adenine-induced CRF mice model. Results exhibited that adenine treatment caused serious renal pathological damages and elevation of serum creatinine and blood urea nitrogen of mice. However, these changes could be significantly reversed by the administration of LJP61A in a dose-dependent manner. Additionally, LJP61A could dramatically reduce the weight loss, improve the urine biochemical index, and regulate the electrolyte disturbance of CRF mice. These results suggested that the renal functions of adenine-induced CRF mice could be improved by LJP61A, which might be developed to a potential therapeutic agent for CRF patients.

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Alleviating VLDL overproduction is an important mechanism for Laminaria japonica polysaccharide to inhibit atherosclerosis in LDLr^−/− mice with diet‐induced insulin resistance

Abstract: These results suggested that LJP61A ameliorated HFD-induced insulin resistance to attenuate VLDL overproduction possibly via regulating insulin signaling, leading to the inhibition of atherosclerosis.

Cited by 24 publications

References 46 publications

Forkhead box protein O1 (FoxO1) regulates lipids metabolism and cell proliferation mediated by insulin and PI3K-Akt-mTOR pathway in goose primary hepatocytes

Forkhead box protein O1 (FoxO1) regulates lipids metabolism and cell proliferation mediated by insulin and PI3K-Akt-mTOR pathway in goose primary hepatocytes

mTOR: A Cellular Regulator Interface in Health and Disease

Renoprotective Effect of <em>Laminaria japonica </em>Polysaccharide in Adenine-Induced Chronic Renal Failure

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