Alliin obtained from leaf extract of garlic grown under<i>in situ</i>conditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats

Nasim, Sekh Abdul; Dhir, Bhupinder; Kapoor, Rohit; Fatima, Sahar; Mahmooduzzafar,; Mujib, A.

doi:10.3109/13880209.2010.521163

Cited by 29 publications

(15 citation statements)

References 19 publications

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“…In addition, alliin reduce the levels of TNF- α in human-umbilical-vein endothelial cells and helps to decrease serum levels of glucose, insulin, triglycerides, and uric acid, as well as insulin resistance, when compared with fructose-fed rats [133, 134]. …”

Section: Phytochemicalsmentioning

confidence: 99%

Modulation of PPAR-γby Nutraceutics as Complementary Treatment for Obesity-Related Disorders and Inflammatory Diseases

et al. 2012

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A direct correlation between adequate nutrition and health is a universally accepted truth. The Western lifestyle, with a high intake of simple sugars, saturated fat, and physical inactivity, promotes pathologic conditions. The main adverse consequences range from cardiovascular disease, type 2 diabetes, and metabolic syndrome to several cancers. Dietary components influence tissue homeostasis in multiple ways and many different functional foods have been associated with various health benefits when consumed. Natural products are an important and promising source for drug discovery. Many anti-inflammatory natural products activate peroxisome proliferator-activated receptors (PPAR); therefore, compounds that activate or modulate PPAR-gamma (PPAR-γ) may help to fight all of these pathological conditions. Consequently, the discovery and optimization of novel PPAR-γ agonists and modulators that would display reduced side effects is of great interest. In this paper, we present some of the main naturally derived products studied that exert an influence on metabolism through the activation or modulation of PPAR-γ, and we also present PPAR-γ-related diseases that can be complementarily treated with nutraceutics from functional foods.

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Section: Phytochemicalsmentioning

confidence: 99%

Modulation of PPAR-γby Nutraceutics as Complementary Treatment for Obesity-Related Disorders and Inflammatory Diseases

et al. 2012

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“…Allicin is unstable and gets converted to various diallyl sulfides [7]. The leaf is primary site for synthesis of alliin from where it gets transferred to other plant parts such as bulb [18]. Alliin concentration was 3.7 mg/g in garlic bulb and 2.79 mg/g in garlic leaves at fresh weight basis in our preliminary experiment.…”

Section: Introductionmentioning

confidence: 95%

Effect of feeding garlic leaves on rumen fermentation, methane emission, plasma glucose kinetics, and nitrogen utilization in sheep

et al. 2017

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BackgroundGarlic and its constituents are reported to have been effective in reducing methane emission and also influence glucose metabolism in body; however, studies in ruminants using garlic leaves are scarce. Garlic leaves contain similar compounds as garlic bulbs, but are discarded in field after garlic bulb harvest. We speculate that feeding garlic leaves might show similar effect as garlic constituents in sheep and could be potential animal feed supplement. Thus, we examined the effect of freeze dried garlic leaves (FDGL) on rumen fermentation, methane emission, plasma glucose kinetics and nitrogen utilization in sheep.MethodsSix sheep were fed Control diet (mixed hay and concentrate (60:40)) or FDGL diet (Control diet supplemented with FDGL at 2.5 g/kg BW0.75 of sheep) using a crossover design. Methane gas emission was measured using open-circuit respiratory chamber. Plasma glucose turnover rate was measured using isotope dilution technique of [U-13C]glucose. Rumen fluid, feces and urine were collected to measure rumen fermentation characteristics and nitrogen utilization.ResultNo significant difference in rumen fermentation parameters was noticed except for rumen ammonia tended to be higher (0.05 < P < 0.1) in FDGL diet. Methane emission per kg dry matter ingested and methane emission per kg dry matter digested were lower (P < 0.05) in FDGL diet. Plasma glucose concentration was similar between diets and plasma glucose turnover rate tended to be higher in FDGL diet (0.05 < P < 0.1). Nitrogen retention was higher (P < 0.05) and microbial nitrogen supply tended to be higher (0.05 < P < 0.1) in FDGL diet.ConclusionFDGL diet did not impair rumen fermentation, improved nitrogen retention; while absence of significant results in reduction of methane emission, glucose turnover rate and microbial nitrogen supply, further studies at higher dose would be necessary to conclude the merit of FDGL as supplement in ruminant feedstuff.

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“…Alliin (S-2-propenyl-L-cysteine sulfoxide) is the predominant form of organosulfur found in garlic [8], which is the primary odorless, sulfur-containing amino acid, and also is a precursor of allicin [9]. Alliin can undergo an enzymatic reaction to produce allicin when garlic tissue is injured, allicin is mother-nature's insecticide with typical odor and shows therapeutic properties [10,11], allicin is a highly unstable molecule, rapidly transformed into a variety of small molecular components [12]. Allicin is not present in intact garlic and hard to obtain commercially, therefore, garlic possesses high therapeutic and pharmacological properties, which activities is attributed to alliin, the main active principle localized in garlic cloves [13].…”

Section: Introductionmentioning

confidence: 99%

The Multivariate Analysis of Foliar Fertilization by Using Random Forest for Improving Alliin Concentration of Garlic (<i>Allium sativum l.</i>)

Shi¹

2018

IJAAS

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This study was for analyzing significance and optimum proportion of components in foliar fertilizer, which aimed on improving alliin concentration of garlic (Allium sativum L.) in field condition. The Study with designed experiments implemented with uniform experimental design method U 30 (30 13 ) (D=0.1926). Alliin concentration from garlic clove was measured by HPLC, the analysis of data set engaged by Random Forest for components significance test and optimal formula calculation. The results shown that the RF is an appropriate choice for this kind of study; the top 3 important components of foliar fertilizer were: Glutathione, Ethanethiol and Mg 2+ ; the application of foliar fertilizer with optimal combination of components had significant effects on improving alliin concentration in garlic clove; there was synergistic interaction between components, combination of different elements can get much better effects. The maximal data of alliin concentration in garlic clove from experiment results obtained 3.5% (mg/g) of fresh weight far more than control 1.5%.

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Alliin obtained from leaf extract of garlic grown underin situconditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats

Cited by 29 publications

References 19 publications

Modulation of PPAR-γby Nutraceutics as Complementary Treatment for Obesity-Related Disorders and Inflammatory Diseases

Modulation of PPAR-γby Nutraceutics as Complementary Treatment for Obesity-Related Disorders and Inflammatory Diseases

Effect of feeding garlic leaves on rumen fermentation, methane emission, plasma glucose kinetics, and nitrogen utilization in sheep

The Multivariate Analysis of Foliar Fertilization by Using Random Forest for Improving Alliin Concentration of Garlic (<i>Allium sativum l.</i>)

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Alliin obtained from leaf extract of garlic grown underin situconditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats

Cited by 29 publications

References 19 publications

Modulation of PPAR-γby Nutraceutics as Complementary Treatment for Obesity-Related Disorders and Inflammatory Diseases

Modulation of PPAR-γby Nutraceutics as Complementary Treatment for Obesity-Related Disorders and Inflammatory Diseases

Effect of feeding garlic leaves on rumen fermentation, methane emission, plasma glucose kinetics, and nitrogen utilization in sheep

The Multivariate Analysis of Foliar Fertilization by Using Random Forest for Improving Alliin Concentration of Garlic (&lt;i&gt;Allium sativum l.&lt;/i&gt;)

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The Multivariate Analysis of Foliar Fertilization by Using Random Forest for Improving Alliin Concentration of Garlic (<i>Allium sativum l.</i>)