Allium cameleon extract improved androgenesis and sexual behavior in male rat (Rattus norvegicus) via attenuation of oxidative damages increased sexual hormone and NO/cGMP cascade

Abstract

Objective: Allium cameleon Cronquist (1981) (Liliaceae) is a bulb belonging to the garlic family, known as a medicinal plant used for its aphrodisiac activities in Cameroonian folk medicine. The present study was conducted to assess the aphrodisiac potentials of Allium cameleon aqueous extracts and investigate on the possible mechanisms by which this could be accomplished. Methods: The behavioral and biochemical tests were used to detect the aphrodisiac properties. The conceivable mechanisms of action of the aqueous extracts were investigated through determination of sexual hormones, nitric oxide, cGMP, and antioxidant activities in male rats treated with different plant extract concentrations. Results: Allium cameleon enhanced sexual excitement, improved semen quality, and the concentrations of testosterone, FSH and LH. Levels of endogenous antioxidant enzymes (CAT, SOD, and GSH) were improved. Penile nitric oxide and cGMP levels were boosted. Significant stimulation in sexual behavior, elevated spermatic production, raised of viability, morphology, count and sperm mobility were also observed. Treated animals exhibited elevated levels of endogenous antioxidant enzymes. Conclusion: These findings suggest that Allium cameleon possess aphrodisiac properties in rats that might be involve in the attenuation of oxidative damage, but also in the increase of sexual hormones production and NO/cGMP cascade.