In a two-level factorial experiment, we consider orthogonal designs that allow joint estimation of the grand mean, all main effects, and certain classes of twolevel interactions, assuming that the remaining effects are all negligible. Based on a judicious allocation of the factorial effects of interest to the columns of a Hadamard matrix, we propose some general classes of orthogonal and saturated designs which include some existing orthogonal main-effect plans of asymmetric factorials as special cases.