Allocentric information represented by self‐referenced spatial coding in the primate medial temporal lobe

Yang, Chunmei; Chen, He; Naya, Yuji

doi:10.1002/hipo.23501

Cited by 13 publications

(18 citation statements)

References 67 publications

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“…Items can be represented in relationship with others, but this allocentric relationship stays anchored to the first person's perspective limited to the front facing FOV characteristic of primates. This view is, I believe, in agreement with that developed by Yang et al (2023, in this issue) and contrasts with the allocentric coding of rodent place cells which are independent of head direction (O'Keefe & Nadel, 1978, but see Jercog et al, 2019). I further suggest that the “allocentric place” in primates including humans, is a learned construct.…”

Section: Introductionsupporting

confidence: 86%

“…This commentary discusses the species dependent reference frames used to perceive scenes, which are issues raised in papers published in the Special Issue of Hippocampus (2023) entitled “Hippocampal system neurons encoding views in different species.” The papers are Corrigan et al (2023), LaChance and Taube (2023), Lee et al (2022), Quian Quiroga (2023), Yang et al (2023), and Zhu et al (2023).…”

Section: Introductionmentioning

confidence: 99%

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A place with a view: A first‐person perspective in the hippocampal memory space

Wirth

2023

Hippocampus

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How do rodents' and primates' differences in visual perception impact the way the brain constructs egocentric and allocentric reference frames to represent stimuli in space? Strikingly, there are important similarities in the egocentric spatial reference frames through which cortical regions represent objects with respect to an animal's head or body in rodents and primates. These egocentric representations are suitable for navigation across species. However, while the rodent hippocampus represents allocentric place, I draw on several pieces of evidence suggesting that an egocentric reference frame is paramount in the primate hippocampus, and relates to the firstperson perspective characteristic of a primate's field of view. I further discuss the link between an allocentric reference frame and a conceptual frame to suggest that an allocentric reference frame is a semantic construct in primates. Finally, I discuss how views probe memory recall and support prospective coding, and as they are based on a first-person perspective, are a powerful tool for probing episodic memory across species.

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Section: Introductionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

A place with a view: A first‐person perspective in the hippocampal memory space

Wirth

2023

Hippocampus

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“…The same applies to the episodic memory for the locations in scenes where objects or rewards have been seen. 10.Several papers (including several in this Special Issue) have highlighted the presence of hippocampal and related neurons in primates including humans that respond to views of scenes, and not to the place where the individual is located (Corrigan et al, 2023; Donoghue et al, 2023; Mao et al, 2021; Tan et al, 2021; Tsitsiklis et al, 2020; Yang et al, 2023; Zhu et al, 2023). This helps to establish the encoding of views as key to understanding hippocampal function in primates including humans (Rolls, 2023b).…”

Section: Discussionmentioning

confidence: 99%

“…This is a commentary on issues important in understanding hippocampal function that are raised by papers in the Special Issue of Hippocampus (2023) entitled “Hippocampal system neurons encoding views in different species” (Alexander et al, 2023; Corrigan et al, 2023; Donoghue et al, 2023; LaChance & Taube, 2023; Lee et al, 2023; Quian Quiroga, 2023; Rolls, 2023b; Ryom et al, 2023; Wang et al, 2023; Wirth, 2023; Yang et al, 2023; Zhu et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Hippocampal spatial view cells, place cells, and concept cells: View representations

Rolls

2023

Hippocampus

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A commentary is provided on issues raised in the Special Issue of Hippocampus (2023) on hippocampal system view representations. First, the evidence for hippocampal and parahippocampal spatial view cells in primates including humans shows that the allocentric representations provided by at least some of these cells are very useful for human memory in that where objects and rewards are seen in the world "out there" is a key component of episodic memory and navigation. Spatial view cell representations provide for memory and navigation to be independent of the place where the individual is currently located and of the egocentric coordinates of the viewed location and the facing direction of the individual. Second, memory and navigation in humans are normally related to the visual cues encoded by spatial view cells that define a location "out there" such as a building, hill, and so forth, not to an unmarked place without local cues and identified only by distant environmental/room cues. Third, "mixed" representations, for example of particular combinations of spatial view and place, can arise if the training has been for only some combinations of place and view, for that is what can then be learned by the hippocampus. Fourth, rodents, with their much less good visual acuity ($1 cycle/ in rats, compared with $60 cycles/ for the human fovea), and rodents' very wide viewing angle for the world ($270 ) might be expected, when using the same computational mechanisms as in primates, to use widely spaced environmental cues to define a place where the rodent is located, supported by inputs about place using local olfactory and tactile cues. Fifth, it is shown how view-point dependent allocentric representations could form a view-point independent allocentric representation for memory and navigation. Sixth, concept cells in humans and primates with connectivity to the hippocampus are compared.concept cells in humans and macaques, episodic memory, hippocampus, navigation, parahippocampal scene area, place cells, spatial view cells | INTRODUCTIONThis is a commentary on issues important in understanding hippocampal function that are raised by papers in the Special Issue of Hippocampus (2023) entitled "Hippocampal system neurons encoding views in different species" (Alexander et al., 2023;

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“…For example, one possibility is that flexibly shifting hippocampal representation and/or the specificity of particular representations is rather specific to humans. Alternatively, the different types of perceptual signals that rodents, primates, and humans rely on during navigation could be transformed from or into self-referenced representations or allocentric reference frames in species specific ways (Alexander et al, 2023;C. Yang et al, 2023;Zhu et al, 2023).…”

Section: Section 4: Recommendationsmentioning

confidence: 99%

Using multi-task experiments to test principles of hippocampal function

Han¹,

Donoghue²,

Cao³

et al. 2023

Preprint

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Investigations of hippocampal functions have revealed a dizzying array of findings, from lesion-based behavioral deficits, to a diverse range of characterized neural activations, to computational models of putative functionality. Across these findings, there remains an ongoing debate about the core function of the hippocampus and the generality of its representation. Researchers have debated whether the hippocampus’s primary role relates to the representation of space, the neural basis of (episodic) memory, or some more-general computation that generalizes across various cognitive domains. Within these different perspectives, there is much debate about the nature of feature encodings. Here, we suggest that in order to evaluate hippocampal responses – investigating, for example, whether neuronal representations are narrowly targeted to particular tasks or if they subserve domain-general purposes – a promising research strategy may be the use of multi-task experiments, or more generally switching between multiple task contexts while recording from the same neurons in a given session. We argue that this strategy – when combined with explicitly defined theoretical motivations that guide experiment design – could be a fruitful approach to better understand how hippocampal representations support different behaviors. In doing so, we briefly review key open questions in the field, as exemplified by articles in this special issue, as well as previous work using multi-task experiments, and extrapolate to consider how this strategy could be further applied to probe fundamental questions about hippocampal function.

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Allocentric information represented by self‐referenced spatial coding in the primate medial temporal lobe

Cited by 13 publications

References 67 publications

A place with a view: A first‐person perspective in the hippocampal memory space

A place with a view: A first‐person perspective in the hippocampal memory space

Hippocampal spatial view cells, place cells, and concept cells: View representations

Using multi-task experiments to test principles of hippocampal function

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